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🤹🏻 subworkflow for protein activity virtual estimation using aracne and viper #8141

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@juanesarango juanesarango commented Mar 26, 2025

Subworkflow for proposed modules: (viper + ARACNe3) + a subworkflow to infer protein activity from the abundance of gene expression of regulatory transcription factors and other components that are involved in how a protein ends up being activated. The understanding of these tissue-specific protein activity mechanisms become very valuable for precision medicine where specific proteins can be targeted by known drugs.

Slack Discussion:

https://nfcore.slack.com/archives/CJRH30T6V/p1743012526710529

Dependencies to be merged before:

PR checklist

Closes #7992

  • This comment contains a description of changes (with reason).
  • If you've fixed a bug or added code that should be tested, add tests!
  • If you've added a new tool - have you followed the module conventions in the contribution docs
  • If necessary, include test data in your PR.
  • Remove all TODO statements.
  • Emit the versions.yml file.
  • Follow the naming conventions.
  • Follow the parameters requirements.
  • Follow the input/output options guidelines.
  • Add a resource label
  • Use BioConda and BioContainers if possible to fulfil software requirements.
  • Ensure that the test works with either Docker / Singularity. Conda CI tests can be quite flaky:
    • For modules:
      • nf-core modules test <MODULE> --profile docker
      • nf-core modules test <MODULE> --profile singularity
      • nf-core modules test <MODULE> --profile conda
    • For subworkflows:
      • nf-core subworkflows test <SUBWORKFLOW> --profile docker
      • nf-core subworkflows test <SUBWORKFLOW> --profile singularity
      • nf-core subworkflows test <SUBWORKFLOW> --profile conda

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add modules + subworkflow for protein activity
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