Skip to content

Model of BG components to learn more about mechanisms of DBS

Notifications You must be signed in to change notification settings

jaber-jaber/BG_Modelling

Folders and files

NameName
Last commit message
Last commit date

Latest commit

Oct 23, 2023
2d227ea · Oct 23, 2023
Oct 22, 2023
Sep 20, 2023
Oct 16, 2023
Oct 23, 2023
Oct 23, 2023
Aug 21, 2023
Aug 21, 2023
Oct 23, 2023
Oct 16, 2023
Oct 23, 2023
Oct 23, 2023
Jul 17, 2023
Oct 23, 2023
Oct 23, 2023
Sep 18, 2023
Oct 23, 2023
Oct 23, 2023
Oct 23, 2023
Oct 22, 2023

Repository files navigation

BG_Modelling

To run the model:

Compile the MOD files by running: nrnivmodl in the terminal.

Run test_simulation.py to see behaviour of model STN cells and GPe cells.

STN cell as defined by: T. Otsuka, T. Abe, T. Tsukagawa, and W.-J. Song, “Conductance-Based Model of the Voltage-Dependent Generation of a Plateau Potential in Subthalamic Neurons,” J Neurophysiol, vol. 92, no. 1, pp. 255–264, Jul. 2004, doi: 10.1152/jn.00508.2003

GPe cell as defined by: A. Nambu and R. Llinas, “Electrophysiology of globus pallidus neurons in vitro,” J Neurophysiol, vol. 72, no. 3, pp. 1127–1139, Sep. 1994, doi: 10.1152/jn.1994.72.3.1127.

Run network.py to generate DBS signal, record STN LFP and plot Seaborn heatmaps/differential LFP recording. Run rasters.py to plot STN or GPe rasters.