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ivborissov committed Feb 16, 2025
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# LikelihoodProfiler
*A package for [practical identifiability analysis](https://en.wikipedia.org/wiki/Identifiability_analysis) and confidence intervals estimation using profile likelihood approach. The package provides a single interface to different profile likelihood methods.*
*A package for [practical identifiability analysis](https://en.wikipedia.org/wiki/Identifiability_analysis) and confidence intervals (CI) estimation using profile likelihood approach. The package provides a single interface to different profile likelihood methods, including optimization-based, integration-based profiles, CI endpoints search and more.*

#### !!! LikelihoodProfiler package underwent a huge redevelopment and now provides a single interface to different profile likelihood methods. If you are looking for a the CICO algorithm (initially implemented in LikelihoodProfiler package) you can use it through the new LikelihoodProfiler interface or directly with [CICO.jl package](https://github.com/insysbio/CICO.jl).
#### !!! LikelihoodProfiler package underwent a huge redevelopment and now provides a single interface to different profile likelihood methods. If you are looking for a the CICO algorithm (initially implemented in LikelihoodProfiler package) you can use it through the new LikelihoodProfiler interface or directly with [CICOBase.jl package](https://github.com/insysbio/CICOBase.jl).

#### !!! The new interface is at an early stage. Feedback and contributions are very welcome!

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To define the `PLProblem` we need the `OptimizationProblem` and the optimal values of the parameters. Also we can set profiling domain with `profile_range` argument and `threshold` which is the confidence level required to estimate confidence intervals. Please, consult `?PLProblem` on the details of the interface.

```julia
using LikelihoodProfiler
using LikelihoodProfiler, Plots

# optimal values of the parameters
optpars = sol.u
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