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doc/api/version_1.0/org/simulator/math/odes/AdaptiveStepsizeIntegrator.html
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doc/api/version_1.0/org/simulator/math/odes/class-use/AdaptiveStepsizeIntegrator.html
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doc/publications/2012_bioinformatics_applications_note/Cover_Letter.pdf
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@@ -119,16 +119,16 @@ \section{Results:} | |
\section{Availability:} | ||
Source code, binaries, and documentation can be freely obtained under the terms | ||
of the LGPL version~3 from the website | ||
\href{http://sourceforge.net/projects/simulation-core/}{http://sourceforge.net/projects/simulation-core/}. | ||
\TODO{\href{https://sourceforge.net/projects/simulation-core}{https://sourceforge.net/projects/simulation-core}}. | ||
\section{Contact:} | ||
\href{mailto:[email protected]}{[email protected]} | ||
\TODO{\href{mailto:[email protected]}{[email protected]}} | ||
% | ||
%\section{Supplementary information:} | ||
% TODO: Provide additional material | ||
%Supplementary data is available at Bioinformatics online. | ||
\end{abstract} | ||
|
||
%%%\vspace{-.25cm} | ||
\vspace{-.25cm} | ||
\section{Introduction} | ||
|
||
As part of the movement towards quantitative biology, modeling, | ||
|
@@ -188,8 +188,7 @@ \section{Introduction} | |
and can therefore easily be integrated into third-party programs. | ||
It comprises several Ordinary Differential Equation (ODE) | ||
solvers and an interpreter for SBML models. It is the first simulation library | ||
based on JSBML \citep{Draeger2011b}. | ||
% the Java library JSBML | ||
based on the Java library JSBML \citep{Draeger2011b}. | ||
% | ||
%Secondly, a graphical and command-line user interface that provides | ||
%a connection to the heuristic optimization framework EvA2 \citep{Kron10EvA2}. | ||
|
@@ -219,14 +218,14 @@ \section{Implementation} | |
\caption[Architecture of the Simulation Core Library]{Architecture of | ||
the Simulation Core Library (simplified). Numerical methods are | ||
strictly separated from differential equation systems. The upper part displays | ||
the unified type hierarchy of all currently included numerical integration | ||
the unified type hierarchy of all currently included numberical integration | ||
methods. The middle part shows the interfaces defining several | ||
special types of the differential equations to be solved by the numerical | ||
methods. | ||
The class \SBMLinterpreter{} (bottom part) implements all of these interfaces | ||
with respect to the information content of a given SBML model. Similarly, an | ||
implementation of further data formats can be included into the | ||
library.}%\vspace{-.6cm}} | ||
library.\vspace{-.6cm}} | ||
\label{fig:Architecture} | ||
\end{figure} | ||
All the solver classes are derived from the abstract class \AbstractDESSolver{} | ||
|
@@ -264,7 +263,7 @@ \section{Implementation} | |
This significantly decreases the computation time during the simulation. | ||
% | ||
An important aspect in the interpretation of SBML models is the | ||
determination of the exact time at which an event occurs, as this influences | ||
determination of the exact time at which an event occurs, as as this influences | ||
the precision of the system's variables. We therefore adjusted the Rosenbrock | ||
solver \citep{Kotcon2011}, an integrator with an adaptive step size, to a very | ||
precise timing of the events. | ||
|
@@ -358,7 +357,7 @@ \section*{Acknowledgement} | |
Virtual Liver (grant number 0315756). | ||
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\paragraph{Conflict of Interest\textcolon} none declared. | ||
\vspace{-.05cm} | ||
\vspace{-.25cm} | ||
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\begin{thebibliography}{} | ||
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