The Drug–Gene Interaction Database (DGIdb) aggregates human genes, drugs, gene products, drugs and drug–gene interaction records to drive hypothesis generation and discovery for clinicians and researchers. Using a combination of expert curation and text-mining, interactions and drug categorizations are drawn from resources like DrugBank, PharmGKB, ChEMBL, the Gene Ontology, and the Human Protein Atlas. Presently, DGIdb contains over 10,000 genes and 20,000 drugs involved in nearly 70,000 drug-gene interactions.

• Need help? Check the DGIdb documentation.
• Couldn't find an answer to your question? Make a new issue in the DGIdb v5 repo.
• Want programmatic access to DGIdb? Try DGIpy and R-DGIdb.

For more information, please see our most recent publication:

Matthew Cannon, James Stevenson, Kathryn Stahl, Rohit Basu, Adam Coffman, Susanna Kiwala, Joshua F McMichael, Kori Kuzma, Dorian Morrissey, Kelsy Cotto, Elaine R Mardis, Obi L Griffith, Malachi Griffith, Alex H Wagner, DGIdb 5.0: rebuilding the drug–gene interaction database for precision medicine and drug discovery platforms, Nucleic Acids Research, Volume 52, Issue D1, 5 January 2024, Pages D1227–D1235, https://doi.org/10.1093/nar/gkad1040