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update scripts
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wangruohan111 committed Apr 23, 2022
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4 changes: 2 additions & 2 deletions README.md
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Expand Up @@ -25,7 +25,7 @@ Since there are some Bioinformatic pre-processing steps in SeCNV pipeline, follo
+ picard

## Data preparation
To run SeCNV, two pre-prepared files, hg19\_mappability.bigWig and hg38\_mappability.bigWig, should be downloaded from ### and put under the Script folder.
To run SeCNV, the bigwig files, hg19\_mappability.bigWig and hg38\_mappability.bigWig, should be downloaded from [Google Drive](https://drive.google.com/drive/folders/1XGuXa9muRtOiAjtz1J4gWO5Qk3c5-PwS?usp=sharing) and put under the Script folder.

The reference hg19 or hg38, which can be downloaded from NCBI, should be prepared and built index.

Expand Down Expand Up @@ -53,7 +53,7 @@ java -jar picard.jar BuildBamIndex I=file_name.sorted.rg.dedup.bam
Please change **hg19.fa** to your reference location and **file\_name** to your FASTQ file name.

### SeCNV
Next, SeCNV take the bam files as input to profile copy number.
Next, SeCNV takes the bam files as input to profile copy number.
```shell
cd Scripts
python SeCNV.py input_fold output_fold ref_file
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