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71 changes: 71 additions & 0 deletions datasets/depmap-omics-ccle.yaml
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Name: The Cancer Dependency Map (DepMap) Cancer Cell Line Encyclopedia (CCLE) Dataset
Description: This dataset consists of whole genome sequencing (WGS), whole exome sequencing (WES), and RNA sequencing files generated from ~1000 cancer cell lines described in Ghandi et al., 2019.
Documentation: https://github.com/broadinstitute/depmap-omics-ccle
Contact: https://forum.depmap.org
ManagedBy: "[Cancer Data Science](https://cancerdatascience.org/), [Broad Institute](https://www.broadinstitute.org/)"
UpdateFrequency: occasionally (as additional sequencings are generated for publicly-releasible CCLE models)
Tags:
- aws-pds
- bam
- biology
- bioinformatics
- cancer
- genetic
- genomic
- Homo sapiens
- life sciences
- short read sequencing
- transcriptomics
- whole exome sequencing
- whole genome sequencing
License: https://grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/accessing-data/using-genomic-data
Citation: Ghandi, Huang, Jané-Valbuena et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569, 503–508 (2019). https://doi.org/10.1038/s41586-019-1186-3
Resources:
- Description: CRAM/BAM files (and their corresponding CRAI/BAI indexes) for RNA, WES, and WGS samples released by The Cancer Dependency Map (DepMap) as part of the Cancer Cell Line Encyclopedia (CCLE) project
ARN: arn:aws:s3:::depmap-omics-ccle
Region: us-east-1
Type: S3 Bucket
- Description: Notifications for new depmap-omics-ccle data
ARN: arn:aws:sns:us-east-1:019511184952:depmap-omics-ccle-object_created
Region: us-east-1
Type: SNS Topic
DataAtWork:
Tutorials:
- Title: DepMap Omics CCLE data on the AWS Open Data Registry
URL: https://github.com/broadinstitute/depmap-omics-ccle
AuthorName: Devin McCabe
Tools & Applications:
- Title: The Cancer Dependency Map (DepMap)
URL: https://depmap.org
AuthorName: Arafeh, Shibue, Dempster et al.
- Title: Cancer Cell Line Encyclopedia (CCLE)
URL: https://sites.broadinstitute.org/ccle
AuthorName: Ghandi, Huang, Jané-Valbuena et al.
Publications:
- Title: Next-generation characterization of the Cancer Cell Line Encyclopedia
URL: https://www.nature.com/articles/s41586-019-1186-3
AuthorName: Ghandi, Huang, Jané-Valbuena et al.
- Title: The present and future of the Cancer Dependency Map
URL: https://www.nature.com/articles/s41568-024-00763-x
AuthorName: Arafeh, Shibue, Dempster et al.
AuthorURL: https://depmap.org
- Title: Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal
URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03020-w
AuthorName: Krill-Burger, Dempster, Borah et al.
- Title: Genetic dependencies associated with transcription factor activities in human cancer cell lines
URL: https://www.sciencedirect.com/science/article/pii/S2211124724005035
AuthorName: Thatikonda, Supper, Wachter et al.
- Title: Bridging the gap between cancer cell line models and tumours using gene expression data
URL: https://www.nature.com/articles/s41416-021-01359-0
AuthorName: Noorbakhsh, Vazquez & McFarland
- Title: Integrated cross-study datasets of genetic dependencies in cancer
URL: https://www.nature.com/articles/s41467-021-21898-7
AuthorName: Pacini, Dempster, Boyle et al.
- Title: Machine learning multi-omics analysis reveals cancer driver dysregulation in pan-cancer cell lines compared to primary tumors
URL: https://www.nature.com/articles/s42003-022-04075-4
AuthorName: Sanders, Chandra, Zebarjadi et al.
- Title: "The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks"
URL: https://link.springer.com/article/10.1186/s13059-023-02877-1
AuthorName: Ben Guebila, Wang, Lopes-Ramos et al.
ADXCategories:
- Healthcare & Life Sciences Data