This repository contains an implementation of the BowTieBuilder Algorithm.
Available on DockerHub.
A simple pathway reconstruction algorithm that attempts to join sources and targets into a BowTie shape. The algorithm takes a network and 2 lists of nodes (source and target sets) as input. It outputs all edges in the network that are on the shortest paths from source to target sets.
Implemented into the Signaling Pathway Reconstruction Streamliner (SPRAS).
Command Line Test:
python btb.py --edges ./input/edges.txt --sources ./input/source.txt --targets ./input/target.txt --output ./output/output.txt
Example Output:
The original paper for BowTieBuilder can be accessed here:
Supper, J., Spangenberg, L., Planatscher, H. et al. BowTieBuilder: modeling signal transduction pathways. BMC Syst Biol 3, 67 (2009). https://doi.org/10.1186/1752-0509-3-67