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A common practice in the analysis of pathogens and their strains is using single nucleotide polymorphisms (SNPs) to reconstruct their evolutionary history. However, genome-wide SNP-based phylogenetic trees are rarely analyzed without any further information. Including the underlying SNP data together with further metadata on the respective samples in the exploration process can facilitate linking the genomic and phenotypic properties of the samples.
We introduce Evidente, a web-application that provides an interactive visual analysis interface for the simultaneous interrogation of phylogenetic relationships, genome-wide SNP data and metadata for samples of an organism. Besides visualizing the phylogenetic tree, Evidente classifies SNPs as supporting or non-supporting of the tree structures and shows the distribution of both types of SNPs among samples and clades of interest. Furthermore, additional metadata can be included in the visualization. Lastly, Evidente includes an enrichment analysis to identify over-represented genomic features encoded by GO-terms within the clades of the tree.
On this User Manual we introduce the different features of Evidente.
Evidente visualizes a phylogenetic tree, its SNP-data and further metadata. The SNP data is also classified wrt. to their distribution within the phylogenetic tree.