INSIdE nano is a web-based tool that highlights connections between phenotypic entities based on their effects on genes. The database behind the INSIdE nano is a network whose nodes are grouped into four categories: Nanomaterial exposures Drug treatments Chemical exposures Diseases For each node in the network, information regarding their effects on the genes is collected. Weights of the edges in the network are correlated to the similarity of these effects between each couple of nodes.
The online version of the tool can be find at: http://inano.biobyte.de/ More information and usage tutorials are available at: http://inano.biobyte.de/help.cgi
Reference paper:
Serra, A., Letunic, I., Fortino, V., Handy, R. D., Fadeel, B., Tagliaferri, R., & Greco, D. (2019). INSIdE NANO: a systems biology framework to contextualize the mechanism-of-action of engineered nanomaterials. Scientific reports, 9(1), 179.
Paper link: https://www.nature.com/articles/s41598-018-37411-y
