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I am phasing a sample of parent/offspring duos/trios/quads using phase_common with the --pedigree flag.
When I ran checks on the output phased data, I found that it contained Mendelian errors that were not present in the original data.
I checked some of affected people/loci in the original data, and found these are all sites where at least one parent had missing genotype data. I think phase_common may be ignoring the pedigree data when it imputes the missing genotypes, and sometimes creating Mendelian errors as a result.
The text was updated successfully, but these errors were encountered:
I am phasing a sample of parent/offspring duos/trios/quads using phase_common with the --pedigree flag.
When I ran checks on the output phased data, I found that it contained Mendelian errors that were not present in the original data.
I checked some of affected people/loci in the original data, and found these are all sites where at least one parent had missing genotype data. I think phase_common may be ignoring the pedigree data when it imputes the missing genotypes, and sometimes creating Mendelian errors as a result.
The text was updated successfully, but these errors were encountered: