Biological Aging Clock in 2026

[nopara73]

After the first year, from 2026 the lab tests are gonna be at home test kits. It might be a good idea to choose an at home test kit where the seller is willing to offer LWC to whoever does the test not through LWC.

[nopara73]

If sponsorship as revenue works out, 2026 could also be the year of VO2Max. I could partner with the VO2Max leaderboard people (https://www.joinzero.co/leaderboard) which would increase the number of athletes, but more importantly people have access to VO2Max more than a blood test or epigenetic aging test. This would drive the cost down to literally zero assuming you have a fitness tracker that measures this.

[nopara73]

I kinda like how accessible blood based biomarkers are turning out, maybe we should choose the next one based on accessibility?

Biological Aging Clocks Based on Traditional Blood Tests (Ranked Best to Worst)

1. PhenoAge

• Why Best: Highly validated, correlates with mortality and disease risk.
• Inputs: Glucose, CRP, WBC, ALP, RDW, and others.
• Output: Biological age aligned with longevity data.
• Strength: Accessible and uses common blood biomarkers.

2. GrimAge

• Why Second: Exceptional for lifespan and disease prediction.
• Inputs: CRP, plasma proteins (and optionally methylation data).
• Output: Predictive biological age and mortality estimate.
• Limitation: May require advanced tools for full functionality.

3. Aging.AI

• Why Third: User-friendly and publicly available platform.
• Inputs: Routine blood markers (e.g., glucose, lipids, liver enzymes).
• Output: Quick biological age calculations.
• Limitation: Less precise in lifespan predictions compared to top options.

4. BloodAge

• Why Fourth: Machine learning-based with strong potential.
• Inputs: Wide range of blood biomarkers.
• Output: Predictive biological age.
• Limitation: Less validated and lacks widespread acceptance.

5. BioAge (Deep Longevity)

• Why Fifth: Sophisticated machine learning but less accessible.
• Inputs: Routine blood biomarkers.
• Output: Biological age insights based on health data.
• Limitation: Less proven in validation studies.

[nopara73]

If you end up doing VO2Max, then you should convert that into biological age so you can show age reduction as that's kind of a staple of the entire endeavor.

[nopara73]

Another interesting idea: bioimpedance scale with a bioaging clock

[nopara73]

could go with trlomere length as well as measuring that is widely supported by many labs

[nopara73]

Use the following prompt for a bunch of AIs and see where that gets us:

I need a list of biological aging clocks that meet all of the following criteria:

They are scientifically recognized and based on published research.
They can be tested at home via commercially available kits.
They are offered by multiple independent companies (i.e., not proprietary to a single company).
Do not include aging clocks that require lab-based imaging (e.g., BrainAGE), clocks based on clinical biomarkers requiring a doctor's visit (e.g., PhenoAge), or those exclusively sold by one company (e.g., DunedinPACE, GrimAge).

Provide only the names of the aging clocks that meet all three criteria, without explanations or additional details.