diff --git a/packages/ketcher-core/src/application/editor/Editor.ts b/packages/ketcher-core/src/application/editor/Editor.ts
index 643b5d3e84..1fad72be35 100644
--- a/packages/ketcher-core/src/application/editor/Editor.ts
+++ b/packages/ketcher-core/src/application/editor/Editor.ts
@@ -425,6 +425,16 @@ export class CoreEditor {
   }
 
   private onSelectMonomer(monomer: MonomerItemType) {
+    if (
+      this.mode instanceof SequenceMode &&
+      !this.isSequenceEditMode &&
+      (SequenceRenderer.chainsCollection.length === 0 ||
+        (SequenceRenderer.chainsCollection.length === 1 &&
+          SequenceRenderer.chainsCollection.chains[0]?.isEmpty))
+    ) {
+      this.mode.turnOnEditMode();
+    }
+
     if (this.mode instanceof SequenceMode) {
       this.mode.insertMonomerFromLibrary(monomer);
     } else {
@@ -433,6 +443,16 @@ export class CoreEditor {
   }
 
   private onSelectRNAPreset(preset: IRnaPreset) {
+    if (
+      this.mode instanceof SequenceMode &&
+      !this.isSequenceEditMode &&
+      (SequenceRenderer.chainsCollection.length === 0 ||
+        (SequenceRenderer.chainsCollection.length === 1 &&
+          SequenceRenderer.chainsCollection.chains[0]?.isEmpty))
+    ) {
+      this.mode.turnOnEditMode();
+    }
+
     if (this.mode instanceof SequenceMode) {
       this.mode.insertPresetFromLibrary(preset);
     } else {
diff --git a/packages/ketcher-core/src/application/editor/modes/SequenceMode.ts b/packages/ketcher-core/src/application/editor/modes/SequenceMode.ts
index 00a450bb1a..cea729f3e5 100644
--- a/packages/ketcher-core/src/application/editor/modes/SequenceMode.ts
+++ b/packages/ketcher-core/src/application/editor/modes/SequenceMode.ts
@@ -1410,7 +1410,6 @@ export class SequenceMode extends BaseMode {
     const history = new EditorHistory(editor);
     const modelChanges = new Command();
     const selections = SequenceRenderer.selections;
-    const wasCanvasEmptyBeforeInsertion = SequenceRenderer.isEmptyCanvas();
 
     if (selections.length > 0) {
       if (
@@ -1448,7 +1447,7 @@ export class SequenceMode extends BaseMode {
       } else {
         this.replaceSelectionsWithMonomer(selections, monomerItem);
       }
-    } else {
+    } else if (editor.isSequenceEditMode) {
       const newNodePosition = this.getNewNodePosition();
 
       const newMonomer = editor.drawingEntitiesManager.createMonomer(
@@ -1480,14 +1479,11 @@ export class SequenceMode extends BaseMode {
 
       modelChanges.addOperation(new ReinitializeModeOperation());
       editor.renderersContainer.update(modelChanges);
-      SequenceRenderer.moveCaretForward();
+      SequenceRenderer.setCaretPositionNextToMonomer(
+        newMonomerSequenceNode.lastMonomerInNode,
+      );
       history.update(modelChanges);
     }
-
-    if (wasCanvasEmptyBeforeInsertion) {
-      this.turnOnEditMode();
-      SequenceRenderer.moveCaretForward();
-    }
   }
 
   private createRnaPresetNode(preset: IRnaPreset, position: Vec2) {
@@ -1687,7 +1683,7 @@ export class SequenceMode extends BaseMode {
       } else {
         this.replaceSelectionsWithPreset(selections, preset);
       }
-    } else {
+    } else if (editor.isSequenceEditMode) {
       const newNodePosition = this.getNewNodePosition();
 
       const newPresetNode = this.createRnaPresetNode(preset, newNodePosition);
@@ -1713,7 +1709,9 @@ export class SequenceMode extends BaseMode {
 
       modelChanges.addOperation(new ReinitializeModeOperation());
       editor.renderersContainer.update(modelChanges);
-      SequenceRenderer.moveCaretForward();
+      SequenceRenderer.setCaretPositionNextToMonomer(
+        newPresetNode.lastMonomerInNode,
+      );
       history.update(modelChanges);
     }
   }
diff --git a/packages/ketcher-core/src/application/render/renderers/sequence/SequenceRenderer.ts b/packages/ketcher-core/src/application/render/renderers/sequence/SequenceRenderer.ts
index 02de9ed942..cac980b739 100644
--- a/packages/ketcher-core/src/application/render/renderers/sequence/SequenceRenderer.ts
+++ b/packages/ketcher-core/src/application/render/renderers/sequence/SequenceRenderer.ts
@@ -363,7 +363,7 @@ export class SequenceRenderer {
     let newCaretPosition = -1;
 
     SequenceRenderer.forEachNode(({ node, nodeIndexOverall }) => {
-      if (node.monomer === monomer) {
+      if (node.monomers.includes(monomer)) {
         newCaretPosition = nodeIndexOverall;
       }
     });
@@ -375,7 +375,7 @@ export class SequenceRenderer {
     let newCaretPosition = -1;
 
     SequenceRenderer.forEachNode(({ node, nodeIndexOverall }) => {
-      if (node.monomer === monomer) {
+      if (node.monomers.includes(monomer)) {
         newCaretPosition = nodeIndexOverall;
       }
     });
@@ -925,7 +925,7 @@ export class SequenceRenderer {
     let rendererToReturn;
 
     SequenceRenderer.forEachNode(({ node }) => {
-      if (node.monomer === monomer) {
+      if (node.monomers.includes(monomer)) {
         rendererToReturn = node.renderer;
       }
     });