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TCcell.hoc
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/*----------------------------------------------------------------------------
THALAMOCORTICAL (TC) RELAY CELL
=================================
Simulations of a single-compartment model of thalamic relay cell.
The geometric and passive parameters of the model are set to give the
capacitance of the cell <200 pF and twice the size of the NRT single
cell model. The conductances of sodium (I_Naleak) and potasium leak
current (I_Kleak) should be adjusted in order to obtain a range of
input resistances that support various oscillations. The apparent input
resistance is ~160 MOhms and the resting membrane potential is ~-65 mV.
These estimates are average values based on multiple studies carried
out in Crunelli's lab in cats and rats. Mind though that these values
vary largely depending on the age of an animal (for ref. see [1]).
The cell is adapted to be used in parallel network simulations if
necessary.
The following active currents are included in the model (the references
describing the models are provided in the descriptions of model (.mod)
files:
- HH mechanism: fast Na+ I_Na and K+ delayed rectifier I_K(DR)
currents. Required for action potential generation.
- I_T: low voltage-activated Ca2+ T-type current. Required for low-
threshold calcium spikes, rebound bursting, and a number of
oscillations including delta and slow (<1 Hz).
- I_AHP: or I_K[Ca] is a Ca2+-activated K+ current. Significant
only in higher order thalamic relay cells.
- I_h anaomalous rectifier current (hyperpolarisation-activated
non-specific cation current) - an essential pacemaking current
working in cooperation with I_T. Adding I_h Ca2+-dependence
results in waxing-and-waning property of oscillations.
- I_CAN: slow Ca2+ dependent non-specific cation current. This
current is required for expanding the range of intrinsic slow
(<1 Hz) oscillation and smoothing the up-state.
- I_Na(P): persistent low voltage-activated Na+ current; provides
input amplification and increase in the input resistence
contributing to the intrinsic slow oscillation.
- I_A: fast transient voltage activated K+ current.
- I_K1: another significant voltage activated K+ current.
- I_K2: another significant voltage activated K+ current.
- I_HVA: high threshold Ca2+ current. At least 4 distinct types of
channels of this kind in TC cells. Involved in high-threshold
bursts.
- I_AMPA
- I_NMDA
- I_GABAa
- I_GABAb
References:
[1] Lee, S.-C., Cruikshank, S.J., and Connors, B.W. Electrical and
chemical synapses between relay neurons in developing thalamus.
Journal of Physiology, 588: 2403-2415, 2010.
Written by Martynas Dervinis @Cardiff University, 2013.
*notes:
*1 - given enarev = 60, ekrev = -90, diam = 60, L = 90,
g_pas = 0.0000470, e_pas = ekrev, cm = 0.88, Ra = 150,
g_naleak = 0.0000091, e_naleak = 10, depth_cad = 17,
taux_cad = 133, cainf_cad = 50e-6, enaHH_hhT = 30, ek = ekrev,
vtraubNa_hhT = -42, vtraubK_hhT = -38, gnabar_hhT = 0.07,
gkbar_hhT = 0.07, pcabar_itGHK = 8.8e-5, eh = -40,
ghbar_iarg = 0.00012, shift_iarg = -18, ginc_iarg = 2,
cainf_iarg = 50e-6, cac_iarg = 0.000450, k2_iarg = 0.000150,
Pc_iarg = 0.017, k4_iarg = 0.00007, nca_iarg = 4, nexp_iarg = 1,
gkbar1_iahp = 0, gkbar2_iahp = 0, tau_m1_min_iahp = 90,
tau_m2_min_iahp = 830, en = 10, gnbar_ican = 0.000072,
k1_ican = 1e11, k2_ican = 0.01, k3_ican = 0.0015,
k4_ican = 0.0007, gnabar_inap = 0.00001612, shift_inap = 0,
gbar1_ia = 0.000242, gbar2_ia = gbar1_ia*0.663,
gbar_ik1 = 0.000014, gbar_ik2 = 0, pcabar_ihvaTC = 0.00001,
nseg = 1
>> Vrest = -65.06, Ri = 160.77 MOhm with stim.amp = -0.02 nA
Ri = 158.56 MOhm with stim.amp = -0.05 nA
*2 - g_pas = 0.0000512, g_naleak = 0.0000091, pcabar_itGHK = 1.8*8.8e-5,
gkbar1_iahp = 0.000001, gnbar_ican = 0.15*0.000072
>> Vrest = -65.04, Ri = 129.78 MOhm with stim.amp = -0.02 nA
Ri = 135.55 MOhm with stim.amp = -0.05 nA
*3 - given enarev = 60, ekrev = -90, diam = 60, L = 90,
g_pas = 0.00004, e_pas = ekrev, cm = 0.88, Ra = 150,
g_naleak = 0.0000033, e_naleak = 10, depth_cad = 17,
taux_cad = 133, cainf_cad = 50e-6, enaHH_hhT = 30, ek = ekrev,
vtraubNa_hhT = -40, vtraubK_hhT = -40, gnabar_hhT = 0.07,
gkbar_hhT = 0.07, pcabar_itGHK = 8.8e-5, eh = -40,
ghbar_iarg = 0.00012, shift_iarg = -18, ginc_iarg = 2,
cainf_iarg = 50e-6, cac_iarg = 450, k2_iarg = 0.000150,
Pc_iarg = 0.017, k4_iarg = 0.00007, nca_iarg = 4, nexp_iarg = 1,
gkbar1_iahp = 0, gkbar2_iahp = 0, tau_m1_min_iahp = 90,
tau_m2_min_iahp = 830, cac_icanm = 0.00045, beta_icanm = 0.0001,
taumin_icanm = 0.1, en = 0, gbar_icanm = 0.0001,
gnabar_inap = 0.00002015, shift_inap = 0, gbar1_ia = 0.000242,
gbar2_ia = gbar1_ia*0.663, gbar_ik1 = 0.000014,
gbar_ik2 = 0.0002, pcabar_ihvaTC = 0.000135, nseg = 1
>> Vrest = -65.06, Ri = 165.7 MOhm with stim.amp = -0.02 nA
Ri = 134.16 MOhm with stim.amp = -0.05 nA
>> @ -75 mV, Ri = 43.69 MOhm with stim.amp = -0.02 nA
----------------------------------------------------------------------------*/
begintemplate TCcell
public soma, gid, devRi, enarev, ekrev, input, is_art
public createSyn, getSyn, getSynList, connect2target
public createMini, getMini, connectMini, inserted, rcount, rlist
external varDt, randomise, globalIndex, min, lambda_f, state
objref AMPAsyn, GLUsyn, GLUfullsyn, GABAAsyn, GABAsyn, GABAfullsyn
objref AMPAsynList, GLUsynList, GLUfullsynList, GABAAsynList, GABAsynList, GABAfullsynList, synList
objref AMPAmini, GABAAmini, minisList, rlist, input, inserted
strdef section
create soma
proc init() {
gid = $1
devRi = $2
section = $s3
insertNil = 1
insertExC = 1
insertHH = 1
insertIT = 1
insertIAHP = 1
insertIh = 1
insertICAN = 1
insertINaP = 1
insertIA = 1
insertIK1 = 1
insertIK2 = 1
insertIHVA = 1
inserted = new Vector(13)
AMPAsynList = new List()
GLUsynList = new List()
GLUfullsynList = new List()
GABAAsynList = new List()
GABAsynList = new List()
GABAfullsynList = new List()
synList = new List()
minisList = new List()
rlist = new List()
input = new List()
input.append(synList)
input.append(minisList)
rcount = 0
enarev = 60
ekrev = -90
GABAarev = -70
soma {
diam = 60
L = 90
}
if (insertNil) {
forall {
insert pas // Passive properties and K+ leak current
inserted.x[0] = 1
g_pas = 0 //0.00004
e_pas = ekrev
cm = 0.88
Ra = 150
insert naleak // Na+ leak current
inserted.x[1] = 1
if (!strcmp(state,"SWDs_short") || !strcmp(state,"SWDs_long") || !strcmp(state,"wake_short") || !strcmp(state,"wake_long")) {
if (!strcmp(section, "FO")) {
g_naleak = 0.000052
} else {
g_naleak = 0.00003
}
} else {
g_naleak = 0
}
e_naleak = 10
insert cad // Intracellular [Ca2+] decay
inserted.x[2] = 1
depth_cad = 17
taux_cad = 133
cainf_cad = 50e-6
insert cadhva // Intracellular [Ca2+] decay
depth_cadhva = 17
taux_cadhva = 133
cainf_cadhva = 0e-6
}
}
if (insertExC && !varDt) {
forall {
insert extracellular // Extracellular fields for monitoring total membrane current
inserted.x[3] = 1
}
}
if (insertHH) {
soma { // HH mechanism
insert hhT
inserted.x[4] = 1
enaHH_hhT = 30
ek = ekrev
vtraubNa_hhT = -40 // the action potential threshold of the HH mechanism: -65.5
vtraubK_hhT = -40
gnabar_hhT = 0.07 // 0.000823 @ vtraub = -45: 2.313 nA, 0.000564 @ vtraub = -70: 2.315 (max: 2.314 nA)
gkbar_hhT = 0.07 // possible working sets: -45 0.045 0.022; -38 0.04 0.017; 30 -42 -38: 0.07 0.07
}
}
if (insertIT) {
forall {
// VB:
/* insert itGHK // LVA I_T[Ca] with GHK equations
inserted.x[5] = 1
if (!strcmp(section, "FO")) {
pcabar_itGHK = 8.8e-5 // 1.8-8.8: 2-10nA; 10e-5: 11.39nA; 11e-5: 12.53nA;
} else if (!strcmp(section, "HO")) {
pcabar_itGHK = 1.5*8.8e-5 //[1.1 1.8]*8.8e-5
}
mshift_itGHK = 0
hshift_itGHK = 0
tau_m_min_itGHK = 0
tau_h_min_itGHK = 0
adj_itGHK = 0
km_itGHK = 6.2
kh_itGHK = 4 */
// LGN:
insert it
inserted.x[5] = 1
if (!strcmp(section, "FO")) {
gcabar_it = 0.0021 // 0.0004-0.0021: 2-10nA; max 0.00144, if adj = 1; max 0.000985, if adj = 1, m_shift_it = 3, h_shift_it = 3
} else if (!strcmp(section, "HO")) {
gcabar_it = 2*0.0021
}
adj_it = 1
tau_m_min_it = 0
if (!strcmp(state,"delta_short") || !strcmp(state,"delta_long")) {
tau_h_min_it = 0
} else {
if (!strcmp(section, "FO")) {
tau_h_min_it = 0
} else if (!strcmp(section, "HO")) {
tau_h_min_it = 0
}
}
m_shift_it = 3
h_shift_it = 3
}
}
if (insertIh) {
forall {
/*insert iarreg // I_h (Na+/K+) current
inserted.x[6] = 1
eh = -40 // reversal potential
ghbar_iarreg = 0.00012 // Max: 0.00061 (2.6 nA), 0.00047 (2 nA), 0.00012 (0.5 nA), Min: 0.000055 (0.233 nA); 0.000012 (0.051 nA).
shift_iarreg = -18 */
insert iarg
inserted.x[6] = 1
eh = -40
if (!strcmp(section, "FO")) {
ghbar_iarg = 0.00011
if (!strcmp(state,"none")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"delta_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"delta_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"slow_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"slow_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"spindles_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"spindles_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"SWDs_short")) {
shift_iarg = 0 // SWDs: -28; else: 0. Min: -28
cac_iarg = 0.000850
} else if (!strcmp(state,"SWDs_long")) {
shift_iarg = 0
cac_iarg = 0.000850 // Min: 0.001400. IT-mediated Ca2+ influxes associated with SWCs are in the range of ~600-700 uM
} else if (!strcmp(state,"wake_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"wake_long")) {
shift_iarg = 0
cac_iarg = 0.000850
}
nca_iarg = 8
ginc_iarg = 0.5
} else if (!strcmp(section, "HO")) {
ghbar_iarg = 0.00011
if (!strcmp(state,"none")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"delta_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"delta_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"slow_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"slow_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"spindles_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"spindles_long")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"SWDs_short")) {
shift_iarg = 0 // SWDs: -10; else: 0. Min: -28
cac_iarg = 0.000850
} else if (!strcmp(state,"SWDs_long")) {
shift_iarg = 0
cac_iarg = 0.000850 // Min: 0.001400. IT-mediated Ca2+ influxes associated with SWCs are in the range of ~650-780 uM
} else if (!strcmp(state,"wake_short")) {
shift_iarg = 0
cac_iarg = 0.000850
} else if (!strcmp(state,"wake_long")) {
shift_iarg = 0
cac_iarg = 0.000850
}
nca_iarg = 8
ginc_iarg = 0.5
}
k2_iarg = 0.000150
Pc_iarg = 0.017
k4_iarg = 0.00007
nexp_iarg = 1
tau_min_iarg = 20
}
}
if (insertICAN) {
forall {
/* insert ican // Nonspecific cation current I_CAN
inserted.x[7] = 1
en = 10
if (!strcmp(section, "FO")) {
gnbar_ican = 0.000005 // (hh, itGHK, iar): 0.00011, 1e11, 0.01, 0.0015, 0.0007
} else if (!strcmp(section, "HO")) { // fast: gnbar_ican = 0.000016, 1e11, 0.01, 0.25, 0.0123
gnbar_ican = 0.000005 // Hughes et al. (2002) used parameters of 1.25e7, 2e4, 0.075, 0.00075
}
k1_ican = 1e11
k2_ican = 0.01
k3_ican = 0.0015
k4_ican = 0.0007 */
/* insert icand // nonspecific cation current ICAN
beta_icand = 0.0001
taumin_icand = 0.1
en = 0
gbar_icand = 0.0003
cac_icand = 0.0009 //0.00045 */
insert icanmTC // nonspecific cation current ICAN
cac_icanmTC = 0.00045
beta_icanmTC = 0.0001
taumin_icanmTC = 0.1
inact_icanmTC = 1
tau_hCa_min_icanmTC = 0.1
en = 0
if (!strcmp(section, "FO")) {
gbar_icanmTC = 0.75*0.0001
} else if (!strcmp(section, "HO")) {
gbar_icanmTC = 0.75*0.0001
}
}
}
if (insertINaP) {
soma { // I_Na(P) Na+ low threshold persistent current
insert inap
inserted.x[8] = 1
gnabar_inap = 0.00002015
shift_inap = 0 // ranges from -3 to 3
}
}
if (insertIA) {
forall {
insert ia // I_A
inserted.x[9] = 1
gbar1_ia = 0.000242 // 0.000242: ~7.6 nA (max)
gbar2_ia = gbar1_ia*0.663
}
}
if (insertIK1) {
forall {
insert ik1 // I_K1
inserted.x[10] = 1
gbar_ik1 = 0.000014 // 0.000014: 307.2 pA (max: 326.8 pA)
}
}
if (insertIK2) {
forall {
insert ik2 // I_K2
inserted.x[11] = 1
gbar_ik2 = 0.0002 // 0.0001: 2.102 nA. 0.0002: 3.93 nA. Max: 4.248 nA
}
}
if (insertIHVA) {
forall {
insert ihvaTC // I_HVA[Ca]
inserted.x[12] = 1
pcabar_ihvaTC = 0.000135 // 0.000135: 4.353 nA (max: 4.38 nA); 0.000062: 2 nA (1.627 nA when shift = 15)
adj_ihvaTC = 1
}
}
//forall nseg = int((L/(0.1*lambda_f(100))+0.9)/2)*2 + 1 // Lambda rule
forall nseg = 1
}
obfunc connect2target() {localobj nc //$o1 - target process, $2 - connection delay, $3 - connection weight
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = -14.5
nc.delay = $2
nc.weight = $3
return nc
}
obfunc connectMini() {localobj nc //$s1 - type of synapse, $2 - connection delay, $3 - connection weight
if (!strcmp($s1,"AMPA") || !strcmp($s1,"GLUfull")) {
nc = new NetCon(AMPAmini, AMPAsyn)
} else if (!strcmp($s1,"GLU")) {
nc = new NetCon(AMPAmini, GLUsyn)
} else if (!strcmp($s1,"GABAa") || !strcmp($s1,"GABA")) {
nc = new NetCon(GABAAmini, GABAAsyn)
}
nc.delay = $2
nc.weight = $3
return nc
}
proc createAMPAsyn() {localobj r // $1 - release probability
soma AMPAsyn = new AMPA_S(0.5)
AMPAsyn.gbar = 0.04
AMPAsyn.Alpha = 10
AMPAsyn.Beta = 3
AMPAsyn.Cmax = 0.5
AMPAsyn.Cdur = 0.3
AMPAsyn.Erev = 0
if (randomise.x[5]) {
AMPAsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
AMPAsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
AMPAsynList.append(AMPAsyn)
synList.append(AMPAsyn)
}
proc createGLUsyn() {localobj r // $1 - release probability
soma GLUsyn = new GLU_S2(0.5)
GLUsyn.gbar_a = 0.034 // 0.4mV, 0.7ms, 26.2ms: 0.04, 10, 3, 0.5, 0.3, 0, 0.85, 0.2, 2500, 3, 2.2364, 25.057, 43.495, 232.27, 1, 0.0003, 0.5, 0.85
GLUsyn.Alpha_a = 10
GLUsyn.Beta_a = 3
GLUsyn.Cmax_a = 0.5
GLUsyn.Cdur_a = 0.3
GLUsyn.Erev_a = 0
GLUsyn.weight_a = 1
GLUsyn.d1 = 1
GLUsyn.tau_D1 = 1200
GLUsyn.tau1_init_b = 3
GLUsyn.a2_b = 2.2364
GLUsyn.tau2_0_b = 25.057
GLUsyn.a3_b = 43.495
GLUsyn.tau3_0_b = 232.27
GLUsyn.tauAdj_b = 1
GLUsyn.gf_b = 0.0003
GLUsyn.Mg_b = 0.5
GLUsyn.weight_b = 1
if (randomise.x[5]) {
GLUsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
GLUsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
GLUsynList.append(GLUsyn)
synList.append(GLUsyn)
}
proc createGLUfullsyn() {localobj r // $1 - release probability
soma GLUfullsyn = new GLU_S3(0.5)
GLUfullsyn.gbar_a = 0.034 // 0.4mV, 0.7ms, 26.2ms: 0.034, 10, 3, 0.5, 0.3, 0, 1, 0.2, 2500, 3, 2.2364, 25.057, 43.495, 232.27, 1, 0.0003, 0.5, 0.85
GLUfullsyn.Alpha_a = 10
GLUfullsyn.Beta_a = 3
GLUfullsyn.Cmax_a = 0.5
GLUfullsyn.Cdur_a = 0.3
GLUfullsyn.Erev_a = 0
GLUfullsyn.weight_a = 1
GLUfullsyn.tau1_init_b = 3
GLUfullsyn.a2_b = 2.2364
GLUfullsyn.tau2_0_b = 25.057
GLUfullsyn.a3_b = 43.495
GLUfullsyn.tau3_0_b = 232.27
GLUfullsyn.tauAdj_b = 1
GLUfullsyn.gf_b = 0.0003
GLUfullsyn.Mg_b = 0.5
GLUfullsyn.weight_b = 0.1 //1
if (!strcmp(section, "FO")) {
if (!strcmp(state,"none")) {
GLUfullsyn.gbase_c = 0.0023
} else if (!strcmp(state,"delta_short")) {
GLUfullsyn.gbase_c = 0.0019 //Delta: 0.0019; Slow: 0.0015; Spindles:0.0009; SWDs:0.0014; Wake:0.00133-0.0013
} else if (!strcmp(state,"delta_long")) {
GLUfullsyn.gbase_c = 0.0019
} else if (!strcmp(state,"slow_short")) {
GLUfullsyn.gbase_c = 0.0015
} else if (!strcmp(state,"slow_long")) {
GLUfullsyn.gbase_c = 0.0015
} else if (!strcmp(state,"spindles_short")) {
GLUfullsyn.gbase_c = 0.0008
} else if (!strcmp(state,"spindles_long")) {
GLUfullsyn.gbase_c = 0.0008
} else if (!strcmp(state,"SWDs_short")) {
GLUfullsyn.gbase_c = 0.001395 // > 0.0013792
} else if (!strcmp(state,"SWDs_long")) {
GLUfullsyn.gbase_c = 0.001395
} else if (!strcmp(state,"wake_short")) {
GLUfullsyn.gbase_c = 0.001325
} else if (!strcmp(state,"wake_long")) {
GLUfullsyn.gbase_c = 0.001325
}
GLUfullsyn.gbase_c = GLUfullsyn.gbase_c + 0.000001*devRi
GLUfullsyn.gbar_c = min(0.0017, (GLUfullsyn.gbase_c/0.0012)*0.0017)
} else if (!strcmp(section, "HO")) {
if (!strcmp(state,"none")) {
GLUfullsyn.gbase_c = 0.00305
} else if (!strcmp(state,"delta_short")) {
GLUfullsyn.gbase_c = 0.00305 //Delta: 0.00305; Slow: 0.0022; Spindles:0.002-0.0021; SWDs:0.0044; Wake:0.0044
} else if (!strcmp(state,"delta_long")) {
GLUfullsyn.gbase_c = 0.00305
} else if (!strcmp(state,"slow_short")) {
GLUfullsyn.gbase_c = 0.0022
} else if (!strcmp(state,"slow_long")) {
GLUfullsyn.gbase_c = 0.0022
} else if (!strcmp(state,"spindles_short")) {
GLUfullsyn.gbase_c = 0.0021
} else if (!strcmp(state,"spindles_long")) {
GLUfullsyn.gbase_c = 0.0021
} else if (!strcmp(state,"SWDs_short")) {
GLUfullsyn.gbase_c = 0.0045 //4Hz: 0.0046; 7Hz: 0.0028
} else if (!strcmp(state,"SWDs_long")) {
GLUfullsyn.gbase_c = 0.0045
} else if (!strcmp(state,"wake_short")) {
GLUfullsyn.gbase_c = 0.0045
} else if (!strcmp(state,"wake_long")) {
GLUfullsyn.gbase_c = 0.0045
}
GLUfullsyn.gbase_c = GLUfullsyn.gbase_c + 0.000001*devRi
if (!strcmp(state,"delta_long") || !strcmp(state,"slow_long") || !strcmp(state,"spindles_long") || !strcmp(state,"SWDs_long") || !strcmp(state,"wake_long")) {
GLUfullsyn.gbar_c = min(0.0017, (GLUfullsyn.gbase_c/0.000775)*0.0017)
} else {
GLUfullsyn.gbar_c = min(0.0017, (GLUfullsyn.gbase_c/0.0012)*0.0017)
}
}
GLUfullsyn.K1_c = 0.05 // (/ms mM) forward binding rate to receptor
GLUfullsyn.K2_c = 0.002 //0.0001 // (/ms) backward (unbinding) rate of receptor
GLUfullsyn.K3_c = 0.03 // (/ms) rate of G-protein production
GLUfullsyn.K4_c = 0.03 // (/ms) rate of G-protein decay
GLUfullsyn.KD_c = 0.0001 // dissociation constant of K+ channel
GLUfullsyn.n_c = 4 // nb of binding sites of G-protein on K+
GLUfullsyn.Erev_c = ekrev // (mV) reversal potential (E_K)
GLUfullsyn.Cmax_c = 0.5 // short pulses
GLUfullsyn.Cdur_c = 1.4
GLUfullsyn.weight_c = 1
if (randomise.x[5]) {
GLUfullsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
GLUfullsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
GLUfullsynList.append(GLUfullsyn)
synList.append(GLUfullsyn)
soma.g_pas = 0
}
proc createGABAAsyn() {localobj r // $1 - release probability
soma GABAAsyn = new GABAa_S(0.5)
GABAAsyn.gbar = 1 // 1.52mV, 2.6ms, 17.9ms: 1, 0.05, 2, 0.5, 1.4, -80, 1
GABAAsyn.Alpha = 0.05
GABAAsyn.Beta = 2
GABAAsyn.Cmax = 0.5
GABAAsyn.Cdur = 1.4
GABAAsyn.Erev = GABAarev // see Pinault et al. (2003)
if (randomise.x[5]) {
GABAAsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
GABAAsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
GABAAsynList.append(GABAAsyn)
synList.append(GABAAsyn)
}
proc createGABAsyn() {localobj r // $1 - release probability
soma GABAsyn = new GABA_S(0.5)
GABAsyn.gbar_a = 1 // 1.52mV, 2.6ms, 17.9ms: 1, 0.05, 2, 0.5, 1.4, -80, 1
GABAsyn.Alpha_a = 0.05
GABAsyn.Beta_a = 2
GABAsyn.Cmax_a = 0.5
GABAsyn.Cdur_a = 1.4
GABAsyn.Erev_a = GABAarev // see Pinault et al. (2003)
GABAsyn.weight_a = 1
GABAsyn.gbar_b = 0.61 // 0.61, 0.2, 0.0028, 0.28, 0.45, 100, 4, -90, 0.5, 1.4: -2.9956 mV, 108.77 ms, 82.72 ms (in response to a burst)
GABAsyn.K1_b = 0.2 // (/ms mM) forward binding rate to receptor
GABAsyn.K2_b = 0.0028 // (/ms) backward (unbinding) rate of receptor
GABAsyn.K3_b = 0.28 // (/ms) rate of G-protein production
GABAsyn.K4_b = 0.45 // (/ms) rate of G-protein decay
GABAsyn.KD_b = 100 // dissociation constant of K+ channel
GABAsyn.n_b = 4 // nb of binding sites of G-protein on K+
GABAsyn.Erev_b = ekrev // (mV) reversal potential (E_K)
GABAsyn.Cmax_b = 0.5 // short pulses
GABAsyn.Cdur_b = 1.4
if (randomise.x[5]) {
GABAsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
GABAsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
GABAsynList.append(GABAsyn)
synList.append(GABAsyn)
}
proc createGABAfullsyn() {localobj r // $1 - release probability
soma GABAfullsyn = new GABA_S2(0.5)
if (!strcmp(section, "FO")) {
GABAfullsyn.gbar_a = 1 // 1.52mV, 2.6ms, 17.9ms: 1, 0.05, 2, 0.5, 1.4, -80, 1
} else if (!strcmp(section, "HO")) {
GABAfullsyn.gbar_a = 1
}
GABAfullsyn.Alpha_a = 0.05
GABAfullsyn.Beta_a = 2
GABAfullsyn.Cmax_a = 0.5
GABAfullsyn.Cdur_a = 1.4
GABAfullsyn.Erev_a = -80 //GABAarev // see Pinault et al. (2003)
GABAfullsyn.weight_a = 1
if (!strcmp(section, "FO")) {
GABAfullsyn.gbar_b = 0.2*0.61 // 0.61, 0.2, 0.0028, 0.28, 0.45, 100, 4, -90, 0.5, 1.4: -2.9956 mV, 108.77 ms, 82.72 ms (in response to a burst)
// 0.00061, 0.2, 0.0028, 0.28, 0.045, 100, 4, -90, 0.5, 1.4
} else if (!strcmp(section, "HO")) {
GABAfullsyn.gbar_b = 0.2*0.61
}
GABAfullsyn.K1_b = 0.2 // (/ms mM) forward bindin0.1*0.61g rate to receptor
GABAfullsyn.K2_b = 0.0028 // (/ms) backward (unbinding) rate of receptor
GABAfullsyn.K3_b = 0.28 // (/ms) rate of G-protein production
GABAfullsyn.K4_b = 0.45 // (/ms) rate of G-protein decay
GABAfullsyn.KD_b = 0.0195 // dissociation constant of K+ channel: 16 - 0.000009, 12 - 0.000042, 8 - 0.0195
GABAfullsyn.n_b = 8 // nb of binding sites of G-protein on K+
GABAfullsyn.Erev_b = ekrev // (mV) reversal potential (E_K)
GABAfullsyn.Cmax_b = 0.5 // short pulses
GABAfullsyn.Cdur_b = 1.4
if (!strcmp(section, "FO")) {
GABAfullsyn.gbar_c = 0 //0.00065 // *0.6 (koefWeiTC)
} else {
GABAfullsyn.gbar_c = 0
}
GABAfullsyn.K1_c = 0.05 // (/ms mM) forward binding rate to receptor
GABAfullsyn.K2_c = 0.005 // (/ms) backward (unbinding) rate of receptor
GABAfullsyn.K3_c = 0.03 // (/ms) rate of G-protein production
GABAfullsyn.K4_c = 0.03 // (/ms) rate of G-protein decay
GABAfullsyn.KD_c = 0.0001 // dissociation constant of K+ channel
GABAfullsyn.n_c = 2 // nb of binding sites of G-protein on K+
GABAfullsyn.Erev_c = -80 // (mV)
GABAfullsyn.Cmax_c = 0.5 // short pulses
GABAfullsyn.Cdur_c = 1.4
GABAfullsyn.weight_c = 1
if (randomise.x[5]) {
GABAfullsyn.P_release = $1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.uniform(0,1)
GABAfullsyn.noiseFromRandom(r)
rlist.append(r)
rcount += 1
}
GABAfullsynList.append(GABAfullsyn)
synList.append(GABAfullsyn)
}
proc createSyn() { // $s1 - the synapse type, $2 - release probability.
if (!strcmp($s1,"AMPA")) {
createAMPAsyn($2)
} else if (!strcmp($s1,"GLU")) {
createGLUsyn($2)
} else if (!strcmp($s1,"GLUfull")) {
createGLUfullsyn($2)
} else if (!strcmp($s1,"GABAa")) {
createGABAAsyn($2)
} else if (!strcmp($s1,"GABA")) {
createGABAsyn($2)
} else if (!strcmp($s1,"GABAfull")) {
createGABAfullsyn($2)
}
}
obfunc getSyn() {localobj syn // $s1 - the synapse type.
if (!strcmp($s1,"AMPA")) {
syn = AMPAsyn
} else if (!strcmp($s1,"GLU")) {
syn = GLUsyn
} else if (!strcmp($s1,"GLUfull")) {
syn = GLUfullsyn
} else if (!strcmp($s1,"GABAa")) {
syn = GABAAsyn
} else if (!strcmp($s1,"GABA")) {
syn = GABAsyn
} else if (!strcmp($s1,"GABAfull")) {
syn = GABAfullsyn
}
return syn
}
obfunc getSynList() {localobj list // $s1 - the synapse type.
if (!strcmp($s1,"AMPA")) {
list = AMPAsynList
} else if (!strcmp($s1,"GLU")) {
list = GLUsynList
} else if (!strcmp($s1,"GLUfull")) {
list = GLUfullsynList
} else if (!strcmp($s1,"GABAa")) {
list = GABAAsynList
} else if (!strcmp($s1,"GABA")) {
list = GABAsynList
} else if (!strcmp($s1,"GABAfull")) {
list = GABAfullsynList
} else {
list = synList
}
return list
}
proc createMini() {localobj mini, r // $s1 - the synapse type, $2 - number of input streams.
mini = new minis()
mini.noise = 1
r = new Random()
{r.Random123_globalindex(globalIndex)}
{r.Random123(rcount, gid)}
r.negexp(1)
mini.noiseFromRandom(r)
rlist.append(r)
rcount += 1
if (!strcmp($s1,"AMPA") || !strcmp($s1,"GLU") || !strcmp($s1,"GLUfull")) {
mini.interval1 = 1*150*$2
mini.interval2 = 1*75*$2
AMPAmini = mini
} else if (!strcmp($s1,"GABAa") || !strcmp($s1,"GABA") || !strcmp($s1,"GABAfull")) {
mini.interval1 = 1*300*$2
mini.interval2 = 1*150*$2
GABAAmini = mini
}
minisList.append(mini)
}
obfunc getMini() {localobj mini // $s1 - the synapse type
if (!strcmp($s1,"AMPA") || !strcmp($s1,"GLU") || !strcmp($s1,"GLUfull")) {
mini = AMPAmini
} else if (!strcmp($s1,"GABAa") || !strcmp($s1,"GABA") || !strcmp($s1,"GABAfull")) {
mini = GABAAmini
}
return mini
}
func is_art() { return 0 }
endtemplate TCcell