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+# RELEASE NOTES
+
+## 0.10.0
+
+This release is a refactor of HOWARD (Highly Open Workflow for Annotation & Ranking toward genomic variant Discovery) in Python, using Parquet and duckDB. 
+
+HOWARD annotates and prioritizes genetic variations, calculates and normalizes annotations, translates files in multiple formats (e.g. vcf, tsv, parquet) and generates variants statistics.
+
+See [README](README.md) and [gitHub](https://github.com/bioinfo-chru-strasbourg/howard) for more explanations.
+
+## Previous releases
+
+See [HOWARD gitHub](https://github.com/bioinfo-chru-strasbourg/howard) for more information about previous releases.
+
+#### 0.9b-07/10/2016:
+- Script creation
+#### 0.9.1b-11/10/2016:
+- Add Prioritization and Translation
+#### 0.9.1b-11/10/2016:
+- Add snpEff annotation and stats
+#### 0.9.8b-21/03/2017:
+- Add Multithreading on Prioritization and Translation
+#### 0.9.9b-18/04/2017:
+- Add Calculation step
+#### 0.9.10b-07/11/2017:
+- Add generic file annotation through --annotation option
+- 	No need to be in configuration file
+- 	Need to be in ANNOVAR database folder (file 'ASSEMBLY_ANN.txt' for annotation 'ANN')
+- Add options: --force , --split
+- Add options for VCFanotation.pl: --show_annoataion, --show_annotations_full
+- Add database download option nowget in VCFanotation.pl
+- Fixes: multithreading, VAF calculation, configuration and check dependencies
+#### 0.9.11b-07/05/2018:
+- Replace VCFTOOLS command to BCFTOOLS command
+- Release added into the output VCF
+- Update SNPEff options
+- Add VARTYPE, CALLING_QUALITY and CALLING_QUALITY_EXPLODE option on calculation
+- Add description on calculations
+#### 0.9.11.1b-14/05/2018:
+- Improve VCF validation
+- Fix snpEff annotation bug
+#### 0.9.11.2b-17/08/2018:
+- Add --vcf input vcf file option
+- Create Output file directory automatically
+- Improve Multithreading
+#### 0.9.12b-24/08/2018:
+- Improve Multithreading
+- Input VCF compressed with BGZIP accepted
+- Output VCF compression level
+- Add VCF input sorting and multiallele split step (by default)
+- Add VCF input normalization step with option --norm
+- Bug fixes
+#### 0.9.13b-04/10/2018:
+- Multithreading improved
+- Change default output vcf
+- Input vcf without samples allowed
+- VCF Validation with contig check
+- Add multi VCF in input option
+- Add --annotate option for BCFTOOLS annotation with a VCF and TAG (beta)
+- Remove no multithreading part code to multithreading with 1 thread
+- Remove --multithreading parameter, only --thread parameter to deal with multithreading
+- Replace --filter and --format parameters by --prioritization and --translation parameters
+- Add snpeff options to VCFannotation.pl
+#### 0.9.14b-21/01/2019:
+- Reorganization of folders (bin, config, docs, toolbox...).
+- Improve Translation (TSV or VCF, sort on fields, selection of fields, filtering on fields), especially memory efficiency
+- Change Number/Type/Description of new INFO/FORMAT header generated
+- Remove snpEff option --snpeff and --snpeff_hgvs. SnpEff is used through --annotation option
+- Add '#' to the TAB/TSV delimiter format header
+- Update dbNSFP config annotation file script
+- Change default configuration files for annotation (add dbSNFP 3.5a, update mcap and regspintron) and prioritization
+- Bug fixed: file identification in annotation configuration
+- Bug fixed: calculation INFO fields header, snpeff parameters options on multithreading
+- Bug fixed: snpeff parameters in command line
+#### 0.9.15b-19/09/2019:
+- Rename HOWARD.sh to HOWARD.
+- Add --nomen_fields parameter and update NOMEN calculation.
+- Add --bcftools_stats and --stats parameter.
+- Change PZScore, PZFlag, PZComment and PZInfos generation, adding default PZ and all PZ filters.
+- Bug fixed: translation fields identification.
+#### 0.9.15.1b-28/05/2020:
+- Bug fixed: NOMEN calculation clear previous NOMEN values if using force option.
+#### 0.9.15.2-12/10/2020:
+- Change --norm parameter by adding '--check-ref=s' in bcftools command.
+- Add --norm_options parameter.
+- force translation VCF by default.
+- Change VAF_stats and add DP_stats.
+#### 0.9.15.4-11/04/2021:
+- Remove --snpeff_threads parameter (for snpEff 5.0e compatibility) and improve --snpeff_stats.
+- Add a check and rehead INFO fields if necessary (prevent some incorrect INFO header format).
+- Fix --compress parameter and add --index parameter.
+#### 0.9.15.5-21/07/2021:
+- Add INFO description Type option, with autodetection.
+- Add prioritization mode 'VaRank'/'max' for score calculation.
+- Add calculation DP, AD, GQ and associated stats.
+- Fix INFO field type for VCF.
+#### 0.9.15.6-16/09/2021:
+- Structural variant compatibility.
+- NOMEN extraction and generation improved, with --nomen_pattern option (only for SNV and InDel).
+- Improve translation with variant sorting.
+- Improve error catching.
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