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feat: add RNDR4 reaction #380

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EarthToMooney opened this issue Jan 29, 2025 · 0 comments
Open

feat: add RNDR4 reaction #380

EarthToMooney opened this issue Jan 29, 2025 · 0 comments

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@EarthToMooney
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The reaction RNDR4 converts UDP to dUDP, and is present in other S. cerevisiae models such as iMM904 (http://bigg.ucsd.edu/models/iMM904/reactions/RNDR4) and iND750 (http://bigg.ucsd.edu/models/iND750/reactions/RNDR4).
It is catalyzed by the ribonucleotide reductase (RNR) complex, which binds UDP (doi:10.1073/pnas.0600443103) and is purported to reduce UDP to dUDP in S. cerevisiae (https://res.slu.se/id/publ/60167) as it does in E. coli (doi:10.1016/S0076-6879(78)51032-X) and mammals (doi:10.1242/dmm.050775). Thus, I think it should be added to the model.

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