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GPR rules for specific fatty acid oxidation reactions MAR02121, MAR02122, MAR02123 #966

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manas-kohli opened this issue Jan 18, 2025 · 0 comments

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@manas-kohli
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manas-kohli commented Jan 18, 2025

Hey, this is a bit of a question/suggestion but I was looking at GPR rules for these reactions (MAR02121, MAR02122, MAR02123) and the genes listed for these reactions are CPT2, CPT1B but these are mitochondrial and as far as the literature suggests, are not expressed in the peroxisome. Actually further to this, peroxisomes don't appear to import carnitine species but instead export fatty acid-carnitine species for further oxidation in the mitochondria. They import activated fatty acids, which appear to have relevant reactions in the peroxisome already in Human1. I think simply deleting these reactions are a bit problematic but I'd like to hear what the Human1 curators think about this and whether these reactions are supported in the literature.

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