diff --git a/model/Fruitfly-GEM.mat b/model/Fruitfly-GEM.mat
index 214c747..676c064 100644
Binary files a/model/Fruitfly-GEM.mat and b/model/Fruitfly-GEM.mat differ
diff --git a/model/Fruitfly-GEM.xml b/model/Fruitfly-GEM.xml
index ae0643b..da869d4 100644
--- a/model/Fruitfly-GEM.xml
+++ b/model/Fruitfly-GEM.xml
@@ -13,10 +13,10 @@
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           <dcterms:created rdf:parseType="Resource">
-            <dcterms:W3CDTF>2023-05-16T15:25:15Z</dcterms:W3CDTF>
+            <dcterms:W3CDTF>2023-08-16T16:25:05Z</dcterms:W3CDTF>
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           <dcterms:modified rdf:parseType="Resource">
-            <dcterms:W3CDTF>2023-05-16T15:25:15Z</dcterms:W3CDTF>
+            <dcterms:W3CDTF>2023-08-16T16:25:05Z</dcterms:W3CDTF>
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@@ -36135,57 +36135,6 @@
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@@ -67271,15 +67220,35 @@
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+      <species metaid="MAM02443e" sboTerm="SBO:0000247" id="MAM02443e" name="malonyl-carnitine" compartment="e" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C10H16NO6">
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+                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/22833583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/c3dc"/>
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                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162761"/>
                   <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/22833583"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/c3dc"/>
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@@ -67287,7 +67256,7 @@
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+      <species metaid="MAM02443m" sboTerm="SBO:0000247" id="MAM02443m" name="malonyl-carnitine" compartment="m" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C10H16NO6">
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@@ -67303,7 +67272,7 @@
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+      <species metaid="MAM02443x" sboTerm="SBO:0000247" id="MAM02443x" name="malonyl-carnitine" compartment="x" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C10H16NO6">
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@@ -67319,7 +67288,7 @@
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+      <species metaid="MAM02443r" sboTerm="SBO:0000247" id="MAM02443r" name="malonyl-carnitine" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C10H16NO6">
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@@ -91450,36 +91419,6 @@
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@@ -100617,36 +100556,6 @@
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@@ -132374,6 +132283,528 @@
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+      <species metaid="MAM20061c" sboTerm="SBO:0000247" id="MAM20061c" name="epsilon-(gamma-L-Glutamyl)-L-lysine" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H21N3O5">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM20061c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:133752"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C21730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM52422"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
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+        </annotation>
+      </species>
+      <species metaid="MAM20061n" sboTerm="SBO:0000247" id="MAM20061n" name="epsilon-(gamma-L-Glutamyl)-L-lysine" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H21N3O5">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM20061n">
+              <bqbiol:is>
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+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:133752"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C21730"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM52422"/>
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+              </bqbiol:is>
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+      <species metaid="MAM01127n" sboTerm="SBO:0000247" id="MAM01127n" name="5-oxoproline" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C5H6NO3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01127n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:18183"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C01879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM964"/>
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
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+      <species metaid="MAM20064c" sboTerm="SBO:0000247" id="MAM20064c" name="Fe(II)-heme o" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C49H56FeN4O5">
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+      <species metaid="MAM01806n" sboTerm="SBO:0000247" id="MAM01806n" name="farnesyl-PP" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C15H25O7P2">
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+      <species metaid="MAM02049n" sboTerm="SBO:0000247" id="MAM02049n" name="heme" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C34H30FeN4O4">
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+      <species metaid="MAM01657r" sboTerm="SBO:0000247" id="MAM01657r" name="dehydrodolichol-diphosphate" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C100H161O7P2">
+        <annotation>
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+      <species metaid="MAM01252n" sboTerm="SBO:0000247" id="MAM01252n" name="acetate" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C2H3O2">
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+      <species metaid="MAM01288n" sboTerm="SBO:0000247" id="MAM01288n" name="ADP-ribose" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C15H21N5O14P2">
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+      <species metaid="MAM20077n" sboTerm="SBO:0000247" id="MAM20077n" name="2-O-acetyl-ADP-D-ribose" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-2" fbc:chemicalFormula="C17H23N5O15P2">
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+        </annotation>
+      </species>
+      <species metaid="MAM02583n" sboTerm="SBO:0000247" id="MAM02583n" name="nicotinamide" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C6H6N2O">
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+      <species metaid="MAM20063n" sboTerm="SBO:0000247" id="MAM20063n" name="alpha-NAD(+)" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C21H26N7O14P2">
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+              </bqbiol:is>
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+        <annotation>
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+              </bqbiol:is>
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+      <species metaid="MAM20065c" sboTerm="SBO:0000247" id="MAM20065c" name="menadiol" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H10O2">
+        <annotation>
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+      <species metaid="MAM20066r" sboTerm="SBO:0000247" id="MAM20066r" name="menaquinol-4" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C31H42O2">
+        <annotation>
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+        <annotation>
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+      <species metaid="MAM20065r" sboTerm="SBO:0000247" id="MAM20065r" name="menadiol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H10O2">
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+        <annotation>
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+      <species metaid="MAM02759g" sboTerm="SBO:0000247" id="MAM02759g" name="PPi" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="HO7P2">
+        <annotation>
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+      <species metaid="MAM03590g" sboTerm="SBO:0000247" id="MAM03590g" name="2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C20H33O7P2">
+        <annotation>
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+            <rdf:Description rdf:about="#MAM03590g">
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+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM20065g" sboTerm="SBO:0000247" id="MAM20065g" name="menadiol" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H10O2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM20065g">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:6746"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM3658"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM20066n" sboTerm="SBO:0000247" id="MAM20066n" name="menaquinol-4" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C31H42O2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM20066n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:193091"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM819046"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM03590n" sboTerm="SBO:0000247" id="MAM03590n" name="2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C20H33O7P2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM03590n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:58756"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM728266"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM20065n" sboTerm="SBO:0000247" id="MAM20065n" name="menadiol" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C11H10O2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM20065n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:6746"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM3658"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00767c" sboTerm="SBO:0000247" id="MAM00767c" name="3-decaprenyl-4-hydroxybenzoate" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C57H85O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00767c">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:84503"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM733937"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00995r" sboTerm="SBO:0000247" id="MAM00995r" name="4-hydroxybenzoate" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C7H5O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00995r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM01316r" sboTerm="SBO:0000247" id="MAM01316r" name="all-trans-decaprenyl-diphosphate" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C50H81O7P2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01316r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:60721"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM731626"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00767r" sboTerm="SBO:0000247" id="MAM00767r" name="3-decaprenyl-4-hydroxybenzoate" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C57H85O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00767r">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:84503"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM733937"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00995g" sboTerm="SBO:0000247" id="MAM00995g" name="4-hydroxybenzoate" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C7H5O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00995g">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM01316g" sboTerm="SBO:0000247" id="MAM01316g" name="all-trans-decaprenyl-diphosphate" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C50H81O7P2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01316g">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:60721"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM731626"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00767g" sboTerm="SBO:0000247" id="MAM00767g" name="3-decaprenyl-4-hydroxybenzoate" compartment="g" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C57H85O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00767g">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:84503"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM733937"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00995n" sboTerm="SBO:0000247" id="MAM00995n" name="4-hydroxybenzoate" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C7H5O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00995n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:17879"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM164"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM01316n" sboTerm="SBO:0000247" id="MAM01316n" name="all-trans-decaprenyl-diphosphate" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-3" fbc:chemicalFormula="C50H81O7P2">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM01316n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:60721"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM731626"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
+      <species metaid="MAM00767n" sboTerm="SBO:0000247" id="MAM00767n" name="3-decaprenyl-4-hydroxybenzoate" compartment="n" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="-1" fbc:chemicalFormula="C57H85O3">
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAM00767n">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:84503"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM733937"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+      </species>
       <species metaid="MAM15003c" sboTerm="SBO:0000247" id="MAM15003c" name="L-Allothreonine" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C4H9NO3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
@@ -132954,21 +133385,19 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM01449r" sboTerm="SBO:0000247" id="MAM01449r" name="cholestenol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C27H46O">
+      <species metaid="MAM01066r" sboTerm="SBO:0000247" id="MAM01066r" name="5alpha-cholesta-7,24-dien-3beta-ol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C27H44O">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM01449r">
+            <rdf:Description rdf:about="#MAM01066r">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/zymstnl"/>
-                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16608"/>
-                  <rdf:li rdf:resource="https://identifiers.org/hmdb/HMDB0006841"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C03845"/>
-                  <rdf:li rdf:resource="https://identifiers.org/lipidmaps/LMST01010096"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM2494"/>
-                  <rdf:li rdf:resource="https://identifiers.org/pubchem.compound/101770"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/zymstnl"/>
-                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.metabolite/chlstol"/>
+                  <rdf:li rdf:resource="https://identifiers.org/chebi/CHEBI:16290"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.compound/C05439"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM162749"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM830"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhmetabolite/chlstol"/>
+                  <rdf:li rdf:resource="https://identifiers.org/inchi/InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -132994,10 +133423,10 @@
           </rdf:RDF>
         </annotation>
       </species>
-      <species metaid="MAM00356r" sboTerm="SBO:0000247" id="MAM00356r" name="13-hydroxy-alpha-tocopherol" compartment="r" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C29H50O3">
+      <species metaid="MAM00356c" sboTerm="SBO:0000247" id="MAM00356c" name="13-hydroxy-alpha-tocopherol" compartment="c" initialConcentration="0" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false" fbc:charge="0" fbc:chemicalFormula="C29H50O3">
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAM00356r">
+            <rdf:Description rdf:about="#MAM00356c">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.chemical/MNXM9688"/>
@@ -133767,6 +134196,42 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
+      <reaction metaid="MAR04372" sboTerm="SBO:0000176" id="MAR04372" name="2,3-bisphospho-D-glycerate 2-phosphohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR04372">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.3.13"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01516"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR107035"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DPGase"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/21904"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00569c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00913c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG18371"/>
+            <fbc:geneProductRef fbc:geneProduct="CG34161"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
+      </reaction>
       <reaction metaid="MAR04373" sboTerm="SBO:0000176" id="MAR04373" name="D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -138203,7 +138668,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03797" sboTerm="SBO:0000176" id="MAR03797" name="Propanoate:CoA ligase (AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03797" sboTerm="SBO:0000176" id="MAR03797" name="Propanoate:CoA ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -138229,14 +138694,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02774m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02772m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02774m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -138402,7 +138867,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04460" sboTerm="SBO:0000176" id="MAR04460" name="ATP:propanoate adenylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04460" sboTerm="SBO:0000176" id="MAR04460" name="ATP:propanoate adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -140260,7 +140725,7 @@
           <fbc:geneProductRef fbc:geneProduct="AMPdeam"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04085" sboTerm="SBO:0000176" id="MAR04085" name="AMP:diphosphate phospho-D-ribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04085" sboTerm="SBO:0000176" id="MAR04085" name="AMP:diphosphate phospho-D-ribosyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -140285,18 +140750,18 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01279c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02806c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Aprt"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04086" sboTerm="SBO:0000176" id="MAR04086" name="AMP:diphosphate phospho-D-ribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04086" sboTerm="SBO:0000176" id="MAR04086" name="AMP:diphosphate phospho-D-ribosyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -140320,12 +140785,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01279e" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02806e" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759e" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Aprt"/>
@@ -144430,7 +144895,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04577" sboTerm="SBO:0000176" id="MAR04577" name="Orotidine-5&apos;-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04577" sboTerm="SBO:0000176" id="MAR04577" name="Orotidine-5&apos;-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -144454,12 +144919,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02660c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM02659c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02806c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02660c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR04579" sboTerm="SBO:0000176" id="MAR04579" name="uridine:phosphate alpha-D-ribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -149299,38 +149764,6 @@
           <fbc:geneProductRef fbc:geneProduct="Got1"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03831" sboTerm="SBO:0000176" id="MAR03831" name="L-aspartate ammonia-lyase (fumarate-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR03831">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.1.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00490"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_3831"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/16601"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01370c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01862c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02578c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Fum1"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR03862" sboTerm="SBO:0000176" id="MAR03862" name="L-asparagine amidohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -150014,6 +150447,12 @@
         <listOfProducts>
           <speciesReference species="MAM01931c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG32196"/>
+            <fbc:geneProductRef fbc:geneProduct="CG4306"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR06972" sboTerm="SBO:0000176" id="MAR06972" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -150042,6 +150481,12 @@
         <listOfProducts>
           <speciesReference species="MAM01928c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG32196"/>
+            <fbc:geneProductRef fbc:geneProduct="CG4306"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR07641" sboTerm="SBO:0000176" id="MAR07641" name="D-Aspartate:oxygen oxidoreductase (deaminating)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -150108,9 +150553,6 @@
         <listOfProducts>
           <speciesReference species="MAM01307c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CG1983"/>
-        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03806" sboTerm="SBO:0000176" id="MAR03806" name="L-glutamate gamma-semialdehyde:NAD+ oxidoreductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -150520,7 +150962,7 @@
           <fbc:geneProductRef fbc:geneProduct="P5CS"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03956" sboTerm="SBO:0000176" id="MAR03956" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03956" sboTerm="SBO:0000176" id="MAR03956" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -161549,9 +161991,6 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG17691"/>
-            <fbc:geneProductRef fbc:geneProduct="CG7430"/>
-            <fbc:geneProductRef fbc:geneProduct="CG8199"/>
             <fbc:geneProductRef fbc:geneProduct="Prx6a"/>
             <fbc:geneProductRef fbc:geneProduct="Pxn"/>
           </fbc:or>
@@ -164466,7 +164905,7 @@
           <speciesReference species="MAM02565c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04532" sboTerm="SBO:0000176" id="MAR04532" name="CTP:N-glycoloylneuraminate cytidylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04532" sboTerm="SBO:0000176" id="MAR04532" name="CTP:N-glycoloylneuraminate cytidylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -164489,12 +164928,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01593c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01623c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02565c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01593c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Csas"/>
@@ -164568,7 +165007,7 @@
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04536" sboTerm="SBO:0000176" id="MAR04536" name="CTP:N-acetylneuraminate cytidylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04536" sboTerm="SBO:0000176" id="MAR04536" name="CTP:N-acetylneuraminate cytidylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -164591,12 +165030,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01592n" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759n" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01623n" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02543n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01592n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759n" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:geneProductRef fbc:geneProduct="Csas"/>
@@ -166230,7 +166669,7 @@
           <speciesReference species="MAM03106g" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01532" sboTerm="SBO:0000176" id="MAR01532" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01532" sboTerm="SBO:0000176" id="MAR01532" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -166253,12 +166692,12 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03026c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01706c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01806c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03026c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -171836,7 +172275,8 @@
           <speciesReference species="MAM02040e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01421e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -172204,10 +172644,11 @@
           <speciesReference species="MAM02191m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR08664" sboTerm="SBO:0000176" id="MAR08664" name="(3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR08664" sboTerm="SBO:0000176" id="MAR08664" name="(3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:29056341</p>
           </body>
         </notes>
         <annotation>
@@ -172220,18 +172661,23 @@
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02491"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96733"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/CITMCOAHm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13787"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13785"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00084m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02192m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00084m" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG8778"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR08665" sboTerm="SBO:0000176" id="MAR08665" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -172261,37 +172707,6 @@
           <speciesReference species="MAM02466m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR08666" sboTerm="SBO:0000176" id="MAR08666" name="(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08666">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.3.25"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/CITRtm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00237"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96735"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/CITMCOALm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/22613"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/22612"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00084m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01261m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02819m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR08667" sboTerm="SBO:0000176" id="MAR08667" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -173643,6 +174058,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:34428349</p>
           </body>
         </notes>
         <annotation>
@@ -173667,12 +174083,13 @@
           <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="SdhA"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhB"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhC"/>
-            <fbc:geneProductRef fbc:geneProduct="SdhD"/>
-          </fbc:and>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="Etfb"/>
+            <fbc:geneProductRef fbc:geneProduct="Gld"/>
+            <fbc:geneProductRef fbc:geneProduct="Gpo1"/>
+            <fbc:geneProductRef fbc:geneProduct="slgA"/>
+            <fbc:geneProductRef fbc:geneProduct="wal"/>
+          </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR06912" sboTerm="SBO:0000176" id="MAR06912" name="diphosphate phosphohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -174160,7 +174577,7 @@
           <fbc:geneProductRef fbc:geneProduct="Sod1"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00188" sboTerm="SBO:0000176" id="MAR00188" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00188" sboTerm="SBO:0000176" id="MAR00188" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174180,14 +174597,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02345c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02344c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02345c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174197,7 +174614,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00192" sboTerm="SBO:0000176" id="MAR00192" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00192" sboTerm="SBO:0000176" id="MAR00192" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174216,14 +174633,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03050c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03051c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03050c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174233,7 +174650,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00196" sboTerm="SBO:0000176" id="MAR00196" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00196" sboTerm="SBO:0000176" id="MAR00196" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174254,14 +174671,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02495c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02494c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02495c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174271,7 +174688,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00200" sboTerm="SBO:0000176" id="MAR00200" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00200" sboTerm="SBO:0000176" id="MAR00200" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174308,7 +174725,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00204" sboTerm="SBO:0000176" id="MAR00204" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00204" sboTerm="SBO:0000176" id="MAR00204" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174344,7 +174761,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00209" sboTerm="SBO:0000176" id="MAR00209" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00209" sboTerm="SBO:0000176" id="MAR00209" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174363,14 +174780,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01141c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02745c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01141c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174380,7 +174797,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00213" sboTerm="SBO:0000176" id="MAR00213" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00213" sboTerm="SBO:0000176" id="MAR00213" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174401,14 +174818,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02689c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02690c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02689c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174418,7 +174835,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00217" sboTerm="SBO:0000176" id="MAR00217" name="Palmitate:CoA ligase (AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00217" sboTerm="SBO:0000176" id="MAR00217" name="Palmitate:CoA ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174442,14 +174859,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02678c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02674c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02678c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174459,7 +174876,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00226" sboTerm="SBO:0000176" id="MAR00226" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00226" sboTerm="SBO:0000176" id="MAR00226" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174480,14 +174897,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02677c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02675c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02677c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174497,7 +174914,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00233" sboTerm="SBO:0000176" id="MAR00233" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00233" sboTerm="SBO:0000176" id="MAR00233" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174517,14 +174934,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01191c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01197c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01191c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174534,7 +174951,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00237" sboTerm="SBO:0000176" id="MAR00237" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00237" sboTerm="SBO:0000176" id="MAR00237" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174554,14 +174971,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02101c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02456c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02101c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174571,7 +174988,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00241" sboTerm="SBO:0000176" id="MAR00241" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00241" sboTerm="SBO:0000176" id="MAR00241" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174607,7 +175024,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00245" sboTerm="SBO:0000176" id="MAR00245" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00245" sboTerm="SBO:0000176" id="MAR00245" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174627,14 +175044,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01237c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01238c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01237c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174644,7 +175061,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00249" sboTerm="SBO:0000176" id="MAR00249" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00249" sboTerm="SBO:0000176" id="MAR00249" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174664,14 +175081,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02941c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02938c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02941c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174681,7 +175098,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00255" sboTerm="SBO:0000176" id="MAR00255" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00255" sboTerm="SBO:0000176" id="MAR00255" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174718,7 +175135,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00259" sboTerm="SBO:0000176" id="MAR00259" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00259" sboTerm="SBO:0000176" id="MAR00259" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174739,14 +175156,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01586c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01585c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01586c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174795,7 +175212,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00267" sboTerm="SBO:0000176" id="MAR00267" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00267" sboTerm="SBO:0000176" id="MAR00267" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174814,14 +175231,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00127c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01778c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00127c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174831,7 +175248,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00271" sboTerm="SBO:0000176" id="MAR00271" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00271" sboTerm="SBO:0000176" id="MAR00271" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174850,14 +175267,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00020c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00115c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00020c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174867,7 +175284,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00275" sboTerm="SBO:0000176" id="MAR00275" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00275" sboTerm="SBO:0000176" id="MAR00275" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174904,7 +175321,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00279" sboTerm="SBO:0000176" id="MAR00279" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00279" sboTerm="SBO:0000176" id="MAR00279" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174923,14 +175340,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02612c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02613c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02612c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174940,7 +175357,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00283" sboTerm="SBO:0000176" id="MAR00283" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00283" sboTerm="SBO:0000176" id="MAR00283" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -174963,14 +175380,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01773c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01771c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01773c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -174980,7 +175397,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00289" sboTerm="SBO:0000176" id="MAR00289" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00289" sboTerm="SBO:0000176" id="MAR00289" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175016,7 +175433,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00293" sboTerm="SBO:0000176" id="MAR00293" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00293" sboTerm="SBO:0000176" id="MAR00293" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175036,14 +175453,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00007c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01584c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00007c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175053,7 +175470,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00297" sboTerm="SBO:0000176" id="MAR00297" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00297" sboTerm="SBO:0000176" id="MAR00297" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175090,7 +175507,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00301" sboTerm="SBO:0000176" id="MAR00301" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00301" sboTerm="SBO:0000176" id="MAR00301" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175110,14 +175527,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00123c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01207c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00123c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175127,7 +175544,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00305" sboTerm="SBO:0000176" id="MAR00305" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00305" sboTerm="SBO:0000176" id="MAR00305" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175146,14 +175563,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00101c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02457c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00101c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175163,7 +175580,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00309" sboTerm="SBO:0000176" id="MAR00309" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00309" sboTerm="SBO:0000176" id="MAR00309" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175182,14 +175599,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02052c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02053c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02052c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175199,7 +175616,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00313" sboTerm="SBO:0000176" id="MAR00313" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00313" sboTerm="SBO:0000176" id="MAR00313" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175219,14 +175636,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01725c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01373c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01725c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175236,7 +175653,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00319" sboTerm="SBO:0000176" id="MAR00319" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00319" sboTerm="SBO:0000176" id="MAR00319" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175256,14 +175673,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00016c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01583c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00016c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175273,7 +175690,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00323" sboTerm="SBO:0000176" id="MAR00323" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00323" sboTerm="SBO:0000176" id="MAR00323" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175292,14 +175709,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00006c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01582c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00006c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175309,7 +175726,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00327" sboTerm="SBO:0000176" id="MAR00327" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00327" sboTerm="SBO:0000176" id="MAR00327" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175328,14 +175745,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03047c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03045c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03047c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175345,7 +175762,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00331" sboTerm="SBO:0000176" id="MAR00331" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00331" sboTerm="SBO:0000176" id="MAR00331" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175364,14 +175781,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02971c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02385c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02971c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175381,7 +175798,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00337" sboTerm="SBO:0000176" id="MAR00337" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00337" sboTerm="SBO:0000176" id="MAR00337" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175400,14 +175817,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00025c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02564c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00025c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175417,7 +175834,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00341" sboTerm="SBO:0000176" id="MAR00341" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00341" sboTerm="SBO:0000176" id="MAR00341" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175436,14 +175853,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02110c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01432c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02110c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175453,7 +175870,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00345" sboTerm="SBO:0000176" id="MAR00345" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00345" sboTerm="SBO:0000176" id="MAR00345" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175472,14 +175889,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02112c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03153c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02112c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175489,7 +175906,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00349" sboTerm="SBO:0000176" id="MAR00349" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00349" sboTerm="SBO:0000176" id="MAR00349" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175509,14 +175926,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02390c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02389c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02390c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175526,7 +175943,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00353" sboTerm="SBO:0000176" id="MAR00353" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00353" sboTerm="SBO:0000176" id="MAR00353" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175545,14 +175962,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00108c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02939c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00108c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175562,7 +175979,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00357" sboTerm="SBO:0000176" id="MAR00357" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00357" sboTerm="SBO:0000176" id="MAR00357" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175581,14 +175998,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00125c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02648c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00125c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175598,7 +176015,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00361" sboTerm="SBO:0000176" id="MAR00361" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00361" sboTerm="SBO:0000176" id="MAR00361" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175618,14 +176035,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00103c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01784c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00103c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175635,7 +176052,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00365" sboTerm="SBO:0000176" id="MAR00365" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00365" sboTerm="SBO:0000176" id="MAR00365" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175655,14 +176072,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00121c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01741c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00121c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175672,7 +176089,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00369" sboTerm="SBO:0000176" id="MAR00369" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00369" sboTerm="SBO:0000176" id="MAR00369" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175708,7 +176125,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00373" sboTerm="SBO:0000176" id="MAR00373" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00373" sboTerm="SBO:0000176" id="MAR00373" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175745,7 +176162,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00377" sboTerm="SBO:0000176" id="MAR00377" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00377" sboTerm="SBO:0000176" id="MAR00377" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175765,14 +176182,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00095c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01689c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00095c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175782,7 +176199,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00381" sboTerm="SBO:0000176" id="MAR00381" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00381" sboTerm="SBO:0000176" id="MAR00381" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175818,7 +176235,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00385" sboTerm="SBO:0000176" id="MAR00385" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00385" sboTerm="SBO:0000176" id="MAR00385" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175854,7 +176271,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00389" sboTerm="SBO:0000176" id="MAR00389" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00389" sboTerm="SBO:0000176" id="MAR00389" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175890,7 +176307,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00393" sboTerm="SBO:0000176" id="MAR00393" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00393" sboTerm="SBO:0000176" id="MAR00393" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175926,7 +176343,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00397" sboTerm="SBO:0000176" id="MAR00397" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00397" sboTerm="SBO:0000176" id="MAR00397" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175948,14 +176365,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02391c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02387c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02391c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -175965,7 +176382,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00401" sboTerm="SBO:0000176" id="MAR00401" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00401" sboTerm="SBO:0000176" id="MAR00401" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -175986,14 +176403,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01934c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01932c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01934c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176003,7 +176420,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00405" sboTerm="SBO:0000176" id="MAR00405" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00405" sboTerm="SBO:0000176" id="MAR00405" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176023,14 +176440,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01697c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01696c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01697c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176040,7 +176457,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00409" sboTerm="SBO:0000176" id="MAR00409" name="Arachidonate:CoA ligase (AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00409" sboTerm="SBO:0000176" id="MAR00409" name="Arachidonate:CoA ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176064,14 +176481,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01364c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01362c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01364c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176081,7 +176498,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00413" sboTerm="SBO:0000176" id="MAR00413" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00413" sboTerm="SBO:0000176" id="MAR00413" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176101,14 +176518,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00119c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01291c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00119c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176118,7 +176535,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00417" sboTerm="SBO:0000176" id="MAR00417" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00417" sboTerm="SBO:0000176" id="MAR00417" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176154,7 +176571,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00421" sboTerm="SBO:0000176" id="MAR00421" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00421" sboTerm="SBO:0000176" id="MAR00421" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176191,7 +176608,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00425" sboTerm="SBO:0000176" id="MAR00425" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00425" sboTerm="SBO:0000176" id="MAR00425" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176228,7 +176645,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00429" sboTerm="SBO:0000176" id="MAR00429" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00429" sboTerm="SBO:0000176" id="MAR00429" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176265,7 +176682,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00433" sboTerm="SBO:0000176" id="MAR00433" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00433" sboTerm="SBO:0000176" id="MAR00433" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176301,7 +176718,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00437" sboTerm="SBO:0000176" id="MAR00437" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00437" sboTerm="SBO:0000176" id="MAR00437" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176320,14 +176737,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00264c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00265c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00264c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176337,7 +176754,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02942" sboTerm="SBO:0000176" id="MAR02942" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02942" sboTerm="SBO:0000176" id="MAR02942" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176356,14 +176773,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02345r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02344r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02345r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176373,7 +176790,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02943" sboTerm="SBO:0000176" id="MAR02943" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02943" sboTerm="SBO:0000176" id="MAR02943" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176392,14 +176809,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03050r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03051r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03050r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176409,7 +176826,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02944" sboTerm="SBO:0000176" id="MAR02944" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02944" sboTerm="SBO:0000176" id="MAR02944" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176428,14 +176845,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02495r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02494r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02495r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176445,7 +176862,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02945" sboTerm="SBO:0000176" id="MAR02945" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02945" sboTerm="SBO:0000176" id="MAR02945" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176464,14 +176881,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01141r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02745r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01141r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176481,7 +176898,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02946" sboTerm="SBO:0000176" id="MAR02946" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02946" sboTerm="SBO:0000176" id="MAR02946" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176517,7 +176934,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02947" sboTerm="SBO:0000176" id="MAR02947" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02947" sboTerm="SBO:0000176" id="MAR02947" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176553,7 +176970,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02948" sboTerm="SBO:0000176" id="MAR02948" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02948" sboTerm="SBO:0000176" id="MAR02948" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176572,14 +176989,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02689r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02690r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02689r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176589,7 +177006,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02949" sboTerm="SBO:0000176" id="MAR02949" name="Palmitate:CoA ligase (AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02949" sboTerm="SBO:0000176" id="MAR02949" name="Palmitate:CoA ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176612,14 +177029,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02678r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02674r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02678r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176629,7 +177046,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02951" sboTerm="SBO:0000176" id="MAR02951" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02951" sboTerm="SBO:0000176" id="MAR02951" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176648,14 +177065,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01191r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01197r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01191r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176665,7 +177082,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02952" sboTerm="SBO:0000176" id="MAR02952" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02952" sboTerm="SBO:0000176" id="MAR02952" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176686,14 +177103,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02677r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02675r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02677r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176703,7 +177120,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02954" sboTerm="SBO:0000176" id="MAR02954" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02954" sboTerm="SBO:0000176" id="MAR02954" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176722,14 +177139,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02101r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02456r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02101r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176739,7 +177156,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02955" sboTerm="SBO:0000176" id="MAR02955" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02955" sboTerm="SBO:0000176" id="MAR02955" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176775,7 +177192,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02956" sboTerm="SBO:0000176" id="MAR02956" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02956" sboTerm="SBO:0000176" id="MAR02956" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176794,14 +177211,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01237r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01238r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01237r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176811,7 +177228,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02957" sboTerm="SBO:0000176" id="MAR02957" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02957" sboTerm="SBO:0000176" id="MAR02957" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176831,14 +177248,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02941r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02938r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02941r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176886,7 +177303,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02961" sboTerm="SBO:0000176" id="MAR02961" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02961" sboTerm="SBO:0000176" id="MAR02961" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176905,14 +177322,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00127r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01778r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00127r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176922,7 +177339,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02962" sboTerm="SBO:0000176" id="MAR02962" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02962" sboTerm="SBO:0000176" id="MAR02962" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176958,7 +177375,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02963" sboTerm="SBO:0000176" id="MAR02963" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02963" sboTerm="SBO:0000176" id="MAR02963" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -176977,14 +177394,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01586r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01585r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01586r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -176994,7 +177411,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02964" sboTerm="SBO:0000176" id="MAR02964" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02964" sboTerm="SBO:0000176" id="MAR02964" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177030,7 +177447,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02965" sboTerm="SBO:0000176" id="MAR02965" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02965" sboTerm="SBO:0000176" id="MAR02965" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177049,14 +177466,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02612r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02613r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02612r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177066,7 +177483,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02966" sboTerm="SBO:0000176" id="MAR02966" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02966" sboTerm="SBO:0000176" id="MAR02966" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177087,14 +177504,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01773r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01771r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01773r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177104,7 +177521,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02967" sboTerm="SBO:0000176" id="MAR02967" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02967" sboTerm="SBO:0000176" id="MAR02967" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177123,14 +177540,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00007r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01584r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00007r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177140,7 +177557,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02968" sboTerm="SBO:0000176" id="MAR02968" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02968" sboTerm="SBO:0000176" id="MAR02968" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177176,7 +177593,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02969" sboTerm="SBO:0000176" id="MAR02969" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02969" sboTerm="SBO:0000176" id="MAR02969" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177212,7 +177629,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02970" sboTerm="SBO:0000176" id="MAR02970" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02970" sboTerm="SBO:0000176" id="MAR02970" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177231,14 +177648,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00123r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01207r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00123r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177248,7 +177665,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02971" sboTerm="SBO:0000176" id="MAR02971" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02971" sboTerm="SBO:0000176" id="MAR02971" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177267,14 +177684,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00101r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02457r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00101r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177284,7 +177701,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02972" sboTerm="SBO:0000176" id="MAR02972" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02972" sboTerm="SBO:0000176" id="MAR02972" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177303,14 +177720,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02052r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02053r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02052r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177320,7 +177737,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02973" sboTerm="SBO:0000176" id="MAR02973" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02973" sboTerm="SBO:0000176" id="MAR02973" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177339,14 +177756,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01725r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01373r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01725r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177356,7 +177773,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02974" sboTerm="SBO:0000176" id="MAR02974" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02974" sboTerm="SBO:0000176" id="MAR02974" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177375,14 +177792,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00016r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01583r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00016r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177392,7 +177809,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02975" sboTerm="SBO:0000176" id="MAR02975" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02975" sboTerm="SBO:0000176" id="MAR02975" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177411,14 +177828,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00006r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01582r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00006r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177428,7 +177845,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02976" sboTerm="SBO:0000176" id="MAR02976" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02976" sboTerm="SBO:0000176" id="MAR02976" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177447,14 +177864,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03047r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03045r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM03047r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177464,7 +177881,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02977" sboTerm="SBO:0000176" id="MAR02977" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02977" sboTerm="SBO:0000176" id="MAR02977" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177483,14 +177900,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02971r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02385r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02971r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177500,7 +177917,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02978" sboTerm="SBO:0000176" id="MAR02978" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02978" sboTerm="SBO:0000176" id="MAR02978" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177519,14 +177936,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00025r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02564r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00025r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177536,7 +177953,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02979" sboTerm="SBO:0000176" id="MAR02979" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02979" sboTerm="SBO:0000176" id="MAR02979" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177555,14 +177972,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02110r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01432r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02110r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177572,7 +177989,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02980" sboTerm="SBO:0000176" id="MAR02980" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02980" sboTerm="SBO:0000176" id="MAR02980" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177591,14 +178008,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02112r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM03153r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02112r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177608,7 +178025,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02981" sboTerm="SBO:0000176" id="MAR02981" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02981" sboTerm="SBO:0000176" id="MAR02981" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177627,14 +178044,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02390r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02389r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02390r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177644,7 +178061,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02982" sboTerm="SBO:0000176" id="MAR02982" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02982" sboTerm="SBO:0000176" id="MAR02982" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177663,14 +178080,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00108r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02939r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00108r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177680,7 +178097,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02983" sboTerm="SBO:0000176" id="MAR02983" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02983" sboTerm="SBO:0000176" id="MAR02983" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177699,14 +178116,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00125r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02648r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00125r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177716,7 +178133,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02984" sboTerm="SBO:0000176" id="MAR02984" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02984" sboTerm="SBO:0000176" id="MAR02984" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177736,14 +178153,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00103r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01784r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00103r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177753,7 +178170,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02985" sboTerm="SBO:0000176" id="MAR02985" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02985" sboTerm="SBO:0000176" id="MAR02985" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177772,14 +178189,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00121r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01741r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00121r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177789,7 +178206,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02986" sboTerm="SBO:0000176" id="MAR02986" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02986" sboTerm="SBO:0000176" id="MAR02986" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177825,7 +178242,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02987" sboTerm="SBO:0000176" id="MAR02987" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02987" sboTerm="SBO:0000176" id="MAR02987" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177862,7 +178279,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02988" sboTerm="SBO:0000176" id="MAR02988" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02988" sboTerm="SBO:0000176" id="MAR02988" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177881,14 +178298,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00095r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01689r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00095r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -177898,7 +178315,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02989" sboTerm="SBO:0000176" id="MAR02989" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02989" sboTerm="SBO:0000176" id="MAR02989" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177934,7 +178351,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02990" sboTerm="SBO:0000176" id="MAR02990" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02990" sboTerm="SBO:0000176" id="MAR02990" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177970,7 +178387,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02991" sboTerm="SBO:0000176" id="MAR02991" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02991" sboTerm="SBO:0000176" id="MAR02991" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -177990,14 +178407,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02391r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02387r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02391r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -178007,7 +178424,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02992" sboTerm="SBO:0000176" id="MAR02992" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02992" sboTerm="SBO:0000176" id="MAR02992" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178028,14 +178445,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01934r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01932r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01934r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -178045,7 +178462,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02994" sboTerm="SBO:0000176" id="MAR02994" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02994" sboTerm="SBO:0000176" id="MAR02994" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178064,14 +178481,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01697r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01696r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01697r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -178081,7 +178498,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02996" sboTerm="SBO:0000176" id="MAR02996" name="Arachidonate:CoA ligase (AMP-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02996" sboTerm="SBO:0000176" id="MAR02996" name="Arachidonate:CoA ligase (AMP-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178103,14 +178520,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01364r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01362r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01364r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -178120,7 +178537,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02998" sboTerm="SBO:0000176" id="MAR02998" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02998" sboTerm="SBO:0000176" id="MAR02998" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178139,14 +178556,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00119r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01291r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00119r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -178156,7 +178573,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02999" sboTerm="SBO:0000176" id="MAR02999" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02999" sboTerm="SBO:0000176" id="MAR02999" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178192,7 +178609,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03000" sboTerm="SBO:0000176" id="MAR03000" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03000" sboTerm="SBO:0000176" id="MAR03000" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178229,7 +178646,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03001" sboTerm="SBO:0000176" id="MAR03001" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03001" sboTerm="SBO:0000176" id="MAR03001" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178265,7 +178682,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03002" sboTerm="SBO:0000176" id="MAR03002" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03002" sboTerm="SBO:0000176" id="MAR03002" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -178301,7 +178718,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03003" sboTerm="SBO:0000176" id="MAR03003" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03003" sboTerm="SBO:0000176" id="MAR03003" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -192635,7 +193052,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01157" sboTerm="SBO:0000176" id="MAR01157" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01157" sboTerm="SBO:0000176" id="MAR01157" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -192656,14 +193073,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01120c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01152c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01120c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -192673,7 +193090,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01158" sboTerm="SBO:0000176" id="MAR01158" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01158" sboTerm="SBO:0000176" id="MAR01158" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -192694,14 +193111,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01120m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01152m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01120m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -192711,7 +193128,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01159" sboTerm="SBO:0000176" id="MAR01159" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01159" sboTerm="SBO:0000176" id="MAR01159" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -192731,14 +193148,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01120r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01152r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01120r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -192748,7 +193165,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01160" sboTerm="SBO:0000176" id="MAR01160" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01160" sboTerm="SBO:0000176" id="MAR01160" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -192769,14 +193186,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01120x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01152x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01120x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -193409,7 +193826,7 @@
           <speciesReference species="MAM02555x" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01200" sboTerm="SBO:0000176" id="MAR01200" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01200" sboTerm="SBO:0000176" id="MAR01200" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -193430,14 +193847,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01122c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01151c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01122c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -193447,7 +193864,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01201" sboTerm="SBO:0000176" id="MAR01201" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01201" sboTerm="SBO:0000176" id="MAR01201" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -193468,14 +193885,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01122m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01151m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01122m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -193485,7 +193902,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01202" sboTerm="SBO:0000176" id="MAR01202" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01202" sboTerm="SBO:0000176" id="MAR01202" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -193506,14 +193923,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01122r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01151r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01122r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -193523,7 +193940,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01203" sboTerm="SBO:0000176" id="MAR01203" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01203" sboTerm="SBO:0000176" id="MAR01203" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -193544,14 +193961,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01122x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM01151x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01122x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194179,7 +194596,7 @@
           <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01248" sboTerm="SBO:0000176" id="MAR01248" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01248" sboTerm="SBO:0000176" id="MAR01248" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194217,7 +194634,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01249" sboTerm="SBO:0000176" id="MAR01249" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01249" sboTerm="SBO:0000176" id="MAR01249" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194255,7 +194672,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01250" sboTerm="SBO:0000176" id="MAR01250" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01250" sboTerm="SBO:0000176" id="MAR01250" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194293,7 +194710,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01251" sboTerm="SBO:0000176" id="MAR01251" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01251" sboTerm="SBO:0000176" id="MAR01251" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194584,7 +195001,7 @@
           <fbc:geneProductRef fbc:geneProduct="didum"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01263" sboTerm="SBO:0000176" id="MAR01263" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01263" sboTerm="SBO:0000176" id="MAR01263" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194605,14 +195022,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00258c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00257c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00258c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194622,7 +195039,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01264" sboTerm="SBO:0000176" id="MAR01264" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01264" sboTerm="SBO:0000176" id="MAR01264" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194643,14 +195060,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00258m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00257m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371m" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00258m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194660,7 +195077,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01265" sboTerm="SBO:0000176" id="MAR01265" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01265" sboTerm="SBO:0000176" id="MAR01265" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194680,14 +195097,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00258r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00257r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00258r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -194697,7 +195114,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01266" sboTerm="SBO:0000176" id="MAR01266" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01266" sboTerm="SBO:0000176" id="MAR01266" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -194718,14 +195135,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00258x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00257x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00258x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -195214,7 +195631,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR01290" sboTerm="SBO:0000176" id="MAR01290" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01290" sboTerm="SBO:0000176" id="MAR01290" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -195235,14 +195652,14 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM00587x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
           <speciesReference species="MAM00586x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01371x" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM01597x" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00587x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01334x" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759x" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
@@ -258311,7 +258728,7 @@
           <fbc:geneProductRef fbc:geneProduct="CG12016"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04254" sboTerm="SBO:0000176" id="MAR04254" name="5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04254" sboTerm="SBO:0000176" id="MAR04254" name="5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -258347,7 +258764,7 @@
           <fbc:geneProductRef fbc:geneProduct="Naprt"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04257" sboTerm="SBO:0000176" id="MAR04257" name="ATP:nicotinamide-nucleotide adenylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04257" sboTerm="SBO:0000176" id="MAR04257" name="ATP:nicotinamide-nucleotide adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -258697,7 +259114,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04276" sboTerm="SBO:0000176" id="MAR04276" name="ATP:nicotinamide-nucleotide adenylyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04276" sboTerm="SBO:0000176" id="MAR04276" name="ATP:nicotinamide-nucleotide adenylyltransferase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -267410,6 +267827,7 @@
             <fbc:geneProductRef fbc:geneProduct="CG9265"/>
             <fbc:geneProductRef fbc:geneProduct="Cralbp"/>
             <fbc:geneProductRef fbc:geneProduct="Dhrs4"/>
+            <fbc:geneProductRef fbc:geneProduct="Fdh"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -276436,7 +276854,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03955" sboTerm="SBO:0000176" id="MAR03955" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03955" sboTerm="SBO:0000176" id="MAR03955" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -276468,16 +276886,7 @@
           <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CAH1"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH16"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH2"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH4"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH5"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH6"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH7"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH9"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CAH1"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR03984" sboTerm="SBO:0000176" id="MAR03984" name="hydrogen-peroxide:hydrogen-peroxide oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -276680,74 +277089,6 @@
           <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR05406" sboTerm="SBO:0000176" id="MAR05406" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10938543;PMID:11493685;PMID:12713833;PMID:12747791;PMID:14640555;PMID:17259996;PMID:17504134;PMID:17826101;PMID:7011879;PMID:7672338</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05406">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/H2CO3D"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00132"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100482"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/H2CO3D"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/10748"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01421c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CAH1"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH16"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH2"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH4"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH5"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH6"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH7"/>
-            <fbc:geneProductRef fbc:geneProduct="CAH9"/>
-          </fbc:or>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR05409" sboTerm="SBO:0000176" id="MAR05409" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05409">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_5409"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01421e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR07794" sboTerm="SBO:0000176" id="MAR07794" name="diphosphate phosphohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -276815,93 +277156,6 @@
           <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR08749" sboTerm="SBO:0000176" id="MAR08749" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08749">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/H2CO3D2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100483"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_8749"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01421c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR08750" sboTerm="SBO:0000176" id="MAR08750" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08750">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/H2CO3D2m"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100483"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_8750"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02046m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01421m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR08751" sboTerm="SBO:0000176" id="MAR08751" name="carbonate hydro-lyase (carbon-dioxide-forming)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08751">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.2.1.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/H2CO3Dm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00132"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100482"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/H2CO3Dm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/10748"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01421m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="CAH1"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR08752" sboTerm="SBO:0000176" id="MAR08752" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -287597,13 +287851,6 @@
         </listOfProducts>
         <fbc:geneProductAssociation>
           <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG15096"/>
-            <fbc:geneProductRef fbc:geneProduct="CG2003"/>
-            <fbc:geneProductRef fbc:geneProduct="CG3649"/>
-            <fbc:geneProductRef fbc:geneProduct="CG7881"/>
-            <fbc:geneProductRef fbc:geneProduct="CG9825"/>
-            <fbc:geneProductRef fbc:geneProduct="CG9864"/>
-            <fbc:geneProductRef fbc:geneProduct="MFS12"/>
             <fbc:geneProductRef fbc:geneProduct="dmGlut"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -290427,39 +290674,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR05295" sboTerm="SBO:0000185" id="MAR05295" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:2835623;PMID:6258180</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05295">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.6.3.9"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/NaKt"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02200e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01285c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02200c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR05296" sboTerm="SBO:0000185" id="MAR05296" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -290548,7 +290762,6 @@
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="CG5535"/>
             <fbc:geneProductRef fbc:geneProduct="Eaat1"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
             <fbc:geneProductRef fbc:geneProduct="slif"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -290586,7 +290799,6 @@
           <fbc:or>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="Eaat1"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -290620,10 +290832,7 @@
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05314" sboTerm="SBO:0000185" id="MAR05314" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290656,10 +290865,7 @@
           <speciesReference species="MAM03135c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05315" sboTerm="SBO:0000185" id="MAR05315" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290695,7 +290901,6 @@
             <fbc:geneProductRef fbc:geneProduct="CD98hc"/>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="CG5535"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
             <fbc:geneProductRef fbc:geneProduct="slif"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -290730,10 +290935,7 @@
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05317" sboTerm="SBO:0000185" id="MAR05317" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290764,10 +290966,7 @@
           <speciesReference species="MAM03089c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05318" sboTerm="SBO:0000185" id="MAR05318" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290798,10 +290997,7 @@
           <speciesReference species="MAM03101c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05319" sboTerm="SBO:0000185" id="MAR05319" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290835,7 +291031,6 @@
           <fbc:or>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="CG5535"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
             <fbc:geneProductRef fbc:geneProduct="slif"/>
           </fbc:or>
         </fbc:geneProductAssociation>
@@ -290870,10 +291065,7 @@
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05322" sboTerm="SBO:0000185" id="MAR05322" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -290945,7 +291137,6 @@
           <fbc:or>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="CG6126"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -290979,10 +291170,7 @@
           <speciesReference species="MAM02993c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR05328" sboTerm="SBO:0000185" id="MAR05328" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -291094,73 +291282,11 @@
           <fbc:geneProductRef fbc:geneProduct="VGlut"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR05333" sboTerm="SBO:0000185" id="MAR05333" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10823827;PMID:12845534</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05333">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HISt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100646"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HISt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.18.6.5"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02125e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02125c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR05413" sboTerm="SBO:0000185" id="MAR05413" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05413">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PIt2r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102872"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PIt6b"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/29941"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/29939"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR05429" sboTerm="SBO:0000185" id="MAR05429" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:2835623;PMID:6258180</p>
             <p>NOTES: DOI:10.1002/9780470691861</p>
           </body>
         </notes>
@@ -320796,10 +320922,7 @@
           <speciesReference species="MAM02896c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG43066"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG43066"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR06377" sboTerm="SBO:0000185" id="MAR06377" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -320835,7 +320958,6 @@
           <fbc:or>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="Eaat1"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -320875,108 +320997,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR06380" sboTerm="SBO:0000185" id="MAR06380" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12845534</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06380">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/GLNt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100261"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.18.6.2"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01975e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01975c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR06381" sboTerm="SBO:0000185" id="MAR06381" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12845534</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06381">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/SERt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104346"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.18.6.8"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02896e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02896c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR06382" sboTerm="SBO:0000185" id="MAR06382" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12845534</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06382">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ASNt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96057"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.18.6.8"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01369e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01369c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR06383" sboTerm="SBO:0000185" id="MAR06383" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -321014,41 +321034,6 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR06384" sboTerm="SBO:0000185" id="MAR06384" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12845534</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06384">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HISt4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100646"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HISSNAT5tc"/>
-                  <rdf:li rdf:resource="https://identifiers.org/tcdb/2.A.18.6.2"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02125e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02125c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR06392" sboTerm="SBO:0000185" id="MAR06392" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -326722,9 +326707,6 @@
           <speciesReference species="MAM01365c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR08631" sboTerm="SBO:0000185" id="MAR08631" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -328537,10 +328519,7 @@
           <speciesReference species="MAM02519c" stoichiometry="1" constant="true"/>
         </listOfProducts>
         <fbc:geneProductAssociation>
-          <fbc:or>
-            <fbc:geneProductRef fbc:geneProduct="CG6126"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
-          </fbc:or>
+          <fbc:geneProductRef fbc:geneProduct="CG6126"/>
         </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR08922" sboTerm="SBO:0000185" id="MAR08922" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -353268,32 +353247,6 @@
           <speciesReference species="MAM00656r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00464" sboTerm="SBO:0000185" id="MAR00464" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00464">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PE_HStg"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102505"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PE_HSter"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02685c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02685r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR00466" sboTerm="SBO:0000185" id="MAR00466" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -367299,7 +367252,7 @@
           <speciesReference species="MAM10005c" stoichiometry="0.005" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00021" sboTerm="SBO:0000629" id="MAR00021" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00021" sboTerm="SBO:0000629" id="MAR00021" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB2N0">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -368662,8 +368615,12 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALDD21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE3076X"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_ALDD21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_RE3076X"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95747"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ALDD21"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/44016"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -371894,71 +371851,6 @@
           <speciesReference species="MAM03591g" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00562" sboTerm="SBO:0000176" id="MAR00562" name="Electron Transfer Flavoprotein" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:3170610;PMID:7601336</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00562">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ETF"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97965"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ETF"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01803m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03573m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01802m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03574m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:and>
-            <fbc:geneProductRef fbc:geneProduct="Etfb"/>
-            <fbc:geneProductRef fbc:geneProduct="wal"/>
-          </fbc:and>
-        </fbc:geneProductAssociation>
-      </reaction>
-      <reaction metaid="MAR00563" sboTerm="SBO:0000176" id="MAR00563" name="Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10444348;PMID:12049629</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00563">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.5.5.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ETFQO"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97966"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/ETFQO"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM03103m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03574m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM03102m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03573m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR00564" sboTerm="SBO:0000627" id="MAR00564" name="Exchange of 1 Acyl Phosphoglycerol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -373332,7 +373224,7 @@
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00737" sboTerm="SBO:0000176" id="MAR00737" name="Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00737" sboTerm="SBO:0000176" id="MAR00737" name="Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -376642,13 +376534,16 @@
         </annotation>
         <listOfReactants>
           <speciesReference species="MAM01371c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02200e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02519c" stoichiometry="2" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01285c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02200c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02519e" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
@@ -382027,7 +381922,7 @@
           <fbc:geneProductRef fbc:geneProduct="Trhn"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR02120" sboTerm="SBO:0000176" id="MAR02120" name="2-Deoxyguanosine 5-Triphosphate Pyrophosphohydrolase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02120" sboTerm="SBO:0000176" id="MAR02120" name="2-Deoxyguanosine 5-Triphosphate Pyrophosphohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -384264,6 +384159,12 @@
         <listOfProducts>
           <speciesReference species="MAM02751e" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG10483"/>
+            <fbc:geneProductRef fbc:geneProduct="CG7536"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR02352" sboTerm="SBO:0000176" id="MAR02352" name="2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -385748,35 +385649,6 @@
           <speciesReference species="MAM01697r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02490" sboTerm="SBO:0000176" id="MAR02490" name="Ribonucleoside-Diphosphate Reductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:6997299;PMID:8483833</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02490">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.17.4.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE0456M"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02990m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03130m" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01756m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02666m" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR02492" sboTerm="SBO:0000176" id="MAR02492" name="3-Hydroxyacyl Coenzyme A Dehydrogenase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -390693,7 +390565,7 @@
           <fbc:geneProductRef fbc:geneProduct="Hacl"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03387" sboTerm="SBO:0000176" id="MAR03387" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03387" sboTerm="SBO:0000176" id="MAR03387" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -393744,7 +393616,7 @@
           <fbc:geneProductRef fbc:geneProduct="Pld"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03801" sboTerm="SBO:0000176" id="MAR03801" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03801" sboTerm="SBO:0000176" id="MAR03801" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -393782,7 +393654,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03803" sboTerm="SBO:0000176" id="MAR03803" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03803" sboTerm="SBO:0000176" id="MAR03803" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -393820,7 +393692,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03805" sboTerm="SBO:0000176" id="MAR03805" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03805" sboTerm="SBO:0000176" id="MAR03805" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -394235,7 +394107,7 @@
           <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR03846" sboTerm="SBO:0000176" id="MAR03846" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03846" sboTerm="SBO:0000176" id="MAR03846" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -394273,7 +394145,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03872" sboTerm="SBO:0000176" id="MAR03872" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03872" sboTerm="SBO:0000176" id="MAR03872" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -394311,7 +394183,7 @@
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR03874" sboTerm="SBO:0000176" id="MAR03874" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR03874" sboTerm="SBO:0000176" id="MAR03874" name="Long-Chain-Fatty-Acid- Coenzyme A Ligase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -398223,35 +398095,6 @@
           <speciesReference species="MAM02096e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR04411" sboTerm="SBO:0000185" id="MAR04411" name="Phosphate Transport In/Out via Na+ Symporter" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12759754</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04411">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PIt8"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102875"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PIt8"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02519e" stoichiometry="1.5" constant="true"/>
-          <speciesReference species="MAM02751e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02519c" stoichiometry="1.5" constant="true"/>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR04413" sboTerm="SBO:0000629" id="MAR04413" name="Generic Human Biomass Reaction" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB2N0">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -398802,38 +398645,6 @@
           <fbc:geneProductRef fbc:geneProduct="whd"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR04562" sboTerm="SBO:0000176" id="MAR04562" name="Production of Myristoylcarnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:19137688;PMID:15653102;PMID:12403251</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04562">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TTDCPT1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104972"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C140CPT1"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02348c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02495c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02973c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="whd"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR04566" sboTerm="SBO:0000185" id="MAR04566" name="Transport of 3-Hydroxytetradecenoyl Coenzyme A from Mitochondria into Cytosol" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -400454,7 +400265,7 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03494e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02443e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
       <reaction metaid="MAR04889" sboTerm="SBO:0000627" id="MAR04889" name="Exchange of Butyryl Carnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -404545,37 +404356,6 @@
           </fbc:and>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR05434" sboTerm="SBO:0000176" id="MAR05434" name="Malonylcoa-&gt;Malonylcarnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12651823;PMID:18192268</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR05434">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FAOXC3DC"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/FAOXC3DC"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02348c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02444c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03494c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="whd"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR05449" sboTerm="SBO:0000176" id="MAR05449" name="Fatty Acid Beta Oxidation (C4-&gt;C2), Mitochondrial" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -404736,6 +404516,8 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FAOXC5C5OHm"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/FAOXC5C5OHm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31081"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/31079"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -404748,6 +404530,9 @@
         <listOfProducts>
           <speciesReference species="MAM03242m" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG8778"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR06278" sboTerm="SBO:0000176" id="MAR06278" name=" (3-Hydroxyisovalerylcoa-&gt;3-Hydroxyisovalerylcarnitine)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -410522,39 +410307,6 @@
           <speciesReference species="MAM02679e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR08985" sboTerm="SBO:0000176" id="MAR08985" name="6-Phosphogluconolactonase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:4382012;PMID:13575411</p>
-            <p>NOTES: Harpers illustrated Biochemistry (2009) 28th edition pages 174-183, ISBN:9781282335806</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08985">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.1.31"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/PGLc"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/PGLc"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01961c" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="3" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01169c" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="3" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Pgls"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR08986" sboTerm="SBO:0000176" id="MAR08986" name="(R)-Pantetheine Amidohydrolase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -410691,37 +410443,6 @@
           <speciesReference species="MAM03102e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR08992" sboTerm="SBO:0000176" id="MAR08992" name="Ribulose 5-Phosphate 3-Epimerase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:4382012;PMID:13575411</p>
-            <p>NOTES: Harpers illustrated Biochemistry (2009) 28th edition pages 174-183, ISBN:9781282335806</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR08992">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.1.3.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RPEc"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RPEc"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02846c" stoichiometry="2" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01761c" stoichiometry="2" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Rpe"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR08993" sboTerm="SBO:0000176" id="MAR08993" name="Formation of Sulfocysteine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -416213,7 +415934,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:11752223</p>
+            <p>AUTHORS: PMID:19789362</p>
           </body>
         </notes>
         <annotation>
@@ -416237,6 +415958,12 @@
           <speciesReference species="MAM02039e" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM01074e" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG2930"/>
+            <fbc:geneProductRef fbc:geneProduct="yin"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR09986" sboTerm="SBO:0000185" id="MAR09986" name="Transport of 5(S)-HPETE, Active Transport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -423950,30 +423677,6 @@
           <speciesReference species="MAM00270e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR10410" sboTerm="SBO:0000185" id="MAR10410" name="Transport of W-Hydroxyl Arachidonic Acid, Diffusion" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR10410">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/WHARACHDtd"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00270c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM00270e" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR10411" sboTerm="SBO:0000185" id="MAR10411" name="Transport of W-Hydroxyl Arachidonic Acid, Intracellular" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -447045,10 +446748,10 @@
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM03494e" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02443e" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM03494c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02443c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR11257" sboTerm="SBO:0000185" id="MAR11257" name="Transport of Butyryl Carnitine" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -448274,7 +447977,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:21749716</p>
+            <p>AUTHORS: PMID:19789362</p>
           </body>
         </notes>
         <annotation>
@@ -448298,6 +448001,14 @@
           <speciesReference species="MAM01074c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:or>
+            <fbc:geneProductRef fbc:geneProduct="CG13384"/>
+            <fbc:geneProductRef fbc:geneProduct="CG2930"/>
+            <fbc:geneProductRef fbc:geneProduct="CG43693"/>
+            <fbc:geneProductRef fbc:geneProduct="yin"/>
+          </fbc:or>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR11308" sboTerm="SBO:0000185" id="MAR11308" name="N-Acetylneuraminate Proton Symport" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -448361,35 +448072,6 @@
           <speciesReference species="MAM03482c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR11310" sboTerm="SBO:0000176" id="MAR11310" name="Carnitine Octadecenoyl Transferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:21749716</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR11310">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C181CPT2rbc"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96396"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C181CPT2rbc"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01597c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02639c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02348c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02647c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR11311" sboTerm="SBO:0000185" id="MAR11311" name="Calcium (Ca+2) Transport via Diffusion (Extracellular to Cytosol)" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -451361,6 +451043,7 @@
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:25575590</p>
           </body>
         </notes>
         <annotation>
@@ -451386,6 +451069,9 @@
           <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02819c" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG5793"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR11431" sboTerm="SBO:0000627" id="MAR11431" name="Exchange of 4-Hydroxybenzoate" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -453552,6 +453238,8 @@
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/3HGLUTCOAm"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/3HGLUTCOAm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/68458"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/68456"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -453564,6 +453252,9 @@
         <listOfProducts>
           <speciesReference species="MAM03222m" stoichiometry="1" constant="true"/>
         </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG8778"/>
+        </fbc:geneProductAssociation>
       </reaction>
       <reaction metaid="MAR11515" sboTerm="SBO:0000176" id="MAR11515" name="Formation of 3-Hydroxy-Glutarate" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
@@ -461904,7 +461595,6 @@
           <fbc:or>
             <fbc:geneProductRef fbc:geneProduct="CG43066"/>
             <fbc:geneProductRef fbc:geneProduct="CG6126"/>
-            <fbc:geneProductRef fbc:geneProduct="GlyT"/>
           </fbc:or>
         </fbc:geneProductAssociation>
       </reaction>
@@ -496365,29 +496055,6 @@
           <speciesReference species="MAM01395e" stoichiometry="1" constant="true"/>
         </listOfReactants>
       </reaction>
-      <reaction metaid="MAR13066" sboTerm="SBO:0000627" id="MAR13066" name="EX_h2co3[e]" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR13066">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EX_h2co3_e"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR98639"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EX_h2co3[e]"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01421e" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-      </reaction>
       <reaction metaid="MAR13067" sboTerm="SBO:0000627" id="MAR13067" name="EX_M02837[e]" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -498164,7 +497831,7 @@
           <speciesReference species="MAM10012c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR13082" sboTerm="SBO:0000629" id="MAR13082" name="Generic human cell biomass reaction" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB2N0">
+      <reaction metaid="MAR13082" sboTerm="SBO:0000629" id="MAR13082" name="Generic human cell biomass reaction" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -500066,41 +499733,6 @@
           <fbc:geneProductRef fbc:geneProduct="Fdh"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR20004" sboTerm="SBO:0000176" id="MAR20004" name="MAR20004" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20004">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.315"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RDH2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_RDH2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R08382"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103441"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/42052"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01232c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01230c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Fdh"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR20005" sboTerm="SBO:0000176" id="MAR20005" name="MAR20005" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -500830,43 +500462,6 @@
           <fbc:geneProductRef fbc:geneProduct="Fdh"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR20045" sboTerm="SBO:0000176" id="MAR20045" name="MAR20045" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20045">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.284"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/FALDH2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_FALDH2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_r1378"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1378"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R06983"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR146812"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/19985"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02152c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01837c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-        <fbc:geneProductAssociation>
-          <fbc:geneProductRef fbc:geneProduct="Fdh"/>
-        </fbc:geneProductAssociation>
-      </reaction>
       <reaction metaid="MAR20046" sboTerm="SBO:0000176" id="MAR20046" name="MAR20046" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -501051,39 +500646,6 @@
           <speciesReference species="MAM02766r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR20052" sboTerm="SBO:0000176" id="MAR20052" name="MAR20052" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR20052">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/ALDD21"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/RE3076X"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_ALDD21"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_RE3076X"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95747"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/44016"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00564c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02039c" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02766c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR20053" sboTerm="SBO:0000176" id="MAR20053" name="MAR20053" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -501616,6 +501178,597 @@
           <fbc:geneProductRef fbc:geneProduct="fbp"/>
         </fbc:geneProductAssociation>
       </reaction>
+      <reaction metaid="MAR20071" sboTerm="SBO:0000176" id="MAR20071" name="MAR20071" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20071">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00490"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR165843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16962"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM20061c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01127c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02426c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR20072" sboTerm="SBO:0000176" id="MAR20072" name="MAR20072" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20072">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.3.2.8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00490"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR165843"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/16962"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM20061n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02426n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01127n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR20089" sboTerm="SBO:0000176" id="MAR20089" name="MAR20089" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20089">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.28"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R02701"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR151808"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/18533"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM01107c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01596c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02897c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="Ddc"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20090" sboTerm="SBO:0000176" id="MAR20090" name="MAR20090" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20090">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07411"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR115959"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28070"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02040m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02049m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01806m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20064m" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="Cox10"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20091" sboTerm="SBO:0000176" id="MAR20091" name="MAR20091" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20091">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07411"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR115959"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28070"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM01806c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02049c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20064c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="Cox10"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20092" sboTerm="SBO:0000176" id="MAR20092" name="MAR20092" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20092">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.-"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.141"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOS_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HEMEOSm_1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R07411"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR115959"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/28070"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02040n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01806n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02049n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20064n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="Cox10"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20098" sboTerm="SBO:0000176" id="MAR20098" name="MAR20098" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20098">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.87"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/53008"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM01806r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02187r" stoichiometry="5" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759r" stoichiometry="5" constant="true"/>
+          <speciesReference species="MAM01657r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="Dhdds"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20099" sboTerm="SBO:0000176" id="MAR20099" name="MAR20099" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20099">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/3.1.1.106"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R12391"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR123366"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/57060"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02040n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20077n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02039n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01252n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01288n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG33054"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20100" sboTerm="SBO:0000176" id="MAR20100" name="MAR20100" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20100">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/68792"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02040n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20063n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02039n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01288n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02583n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG33054"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20102" sboTerm="SBO:0000176" id="MAR20102" name="MAR20102" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20102">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.M22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/74083"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM03590c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20065c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20066c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20103" sboTerm="SBO:0000176" id="MAR20103" name="MAR20103" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20103">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.M22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/74083"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM03590r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20065r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20066r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20104" sboTerm="SBO:0000176" id="MAR20104" name="MAR20104" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20104">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.M22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/74083"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM03590g" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20065g" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM20066g" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02759g" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20105" sboTerm="SBO:0000176" id="MAR20105" name="MAR20105" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20105">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.M22"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/74083"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM03590n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20065n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM20066n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20106" sboTerm="SBO:0000176" id="MAR20106" name="MAR20106" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20106">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/44564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00995c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01316c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00767c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20107" sboTerm="SBO:0000176" id="MAR20107" name="MAR20107" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20107">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/44564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00995r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01316r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00767r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20108" sboTerm="SBO:0000176" id="MAR20108" name="MAR20108" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20108">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/44564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00995g" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01316g" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759g" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00767g" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20109" sboTerm="SBO:0000176" id="MAR20109" name="MAR20109" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20109">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.5.1.39"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_HBZOPT10m"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR100567"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/44564"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM00995n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01316n" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM02759n" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00767n" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="heix"/>
+        </fbc:geneProductAssociation>
+      </reaction>
+      <reaction metaid="MAR20110" sboTerm="SBO:0000176" id="MAR20110" name="MAR20110" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:25575590</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR20110">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR102097"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15642"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/15641"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02633m" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02819m" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+        <fbc:geneProductAssociation>
+          <fbc:geneProductRef fbc:geneProduct="CG5793"/>
+        </fbc:geneProductAssociation>
+      </reaction>
       <reaction metaid="MAR15001" sboTerm="SBO:0000176" id="MAR15001" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -502595,68 +502748,96 @@
           <fbc:geneProductRef fbc:geneProduct="se"/>
         </fbc:geneProductAssociation>
       </reaction>
-      <reaction metaid="MAR00114" sboTerm="SBO:0000176" id="MAR00114" name="C-3 Sterol Dehydrogenase (4-Methylzymosterol)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00113" sboTerm="SBO:0000176" id="MAR00113" name="C-3 Sterol Dehydrogenase (4-Methylzymosterol)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12829805</p>
+            <p>AUTHORS: PMID:10710235;PMID:14506130</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00114">
+            <rdf:Description rdf:about="#MAR00113">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C3STDH1r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96410"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C3STDH1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C3STDH1Pr"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR95038"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C3STDH1Pr"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02552r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00953r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM01596r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM00809r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00118" sboTerm="SBO:0000176" id="MAR00118" name="C-4 Methyl Sterol Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00222" sboTerm="SBO:0000176" id="MAR00222" name="24-Dehydrocholesterol Reductase [Precursor]" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:17984220;PMID:19520779;PMID:19520780</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00118">
+            <rdf:Description rdf:about="#MAR00222">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/C4STMO2r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96420"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/C4STMO2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.3.1.42"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DHCR243r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97382"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DHCR243r"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02552r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00809r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01803r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01675r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01596r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02553r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM04082r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01450r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01802r" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR00443" sboTerm="SBO:0000176" id="MAR00443" name="3-Beta-Hydroxysteroid-Delta (8), Delta (7)-Isomerase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>AUTHORS: PMID:10391219</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR00443">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.5"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EBP1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96689"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EBP1r"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM03158r" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM01066r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR01498" sboTerm="SBO:0000176" id="MAR01498" name="Lanosterol Synthase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -502688,7 +502869,7 @@
           <speciesReference species="MAM02336r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR01510" sboTerm="SBO:0000176" id="MAR01510" name="Lathosterol Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR01508" sboTerm="SBO:0000176" id="MAR01508" name="Lathosterol Oxidase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -502698,13 +502879,13 @@
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR01510">
+            <rdf:Description rdf:about="#MAR01508">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.3.2"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LSTO2r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101245"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/LSTO2r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/LSTO1r"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101244"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/LSTO1r"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
@@ -502714,12 +502895,12 @@
           <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02343r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01066r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM02040r" stoichiometry="2" constant="true"/>
           <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02805r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01189r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR01714" sboTerm="SBO:0000176" id="MAR01714" name="Squalene Epoxidase, Endoplasmic Reticular (NADP)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -502824,66 +503005,35 @@
           <speciesReference species="MAM00941r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02337" sboTerm="SBO:0000176" id="MAR02337" name="Delta24-Sterol Reductase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR02301" sboTerm="SBO:0000176" id="MAR02301" name="Hydroxysteroid (17-Beta) Dehydrogenase 7" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:12162789;PMID:9291139;PMID:9638657</p>
+            <p>AUTHORS: PMID:10544267;PMID:12732193;PMID:12829805</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02337">
+            <rdf:Description rdf:about="#MAR02301">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.3.1.72"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1380"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR105284"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1380"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.270"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/r1135"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1135"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM03158r" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
+          <speciesReference species="MAM02039r" stoichiometry="3" constant="true"/>
           <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01449r" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
-      <reaction metaid="MAR02339" sboTerm="SBO:0000176" id="MAR02339" name="5Alpha-Cholest-7-En-3Beta-Ol Delta7-Delta8-Isomerase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:10391219;PMID:12133002;PMID:4475632;PMID:5810070</p>
-            <p>NOTES: reaction added by gap filling</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02339">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/5.3.3.5"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/EBP2r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR96687"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/EBP2r"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r1381"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM02343r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00809r" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01449r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00968r" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR05151" sboTerm="SBO:0000176" id="MAR05151" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -502956,38 +503106,37 @@
           <speciesReference species="MAM03082c" stoichiometry="43" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04106" sboTerm="SBO:0000176" id="MAR04106" name="malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR04497" sboTerm="SBO:0000176" id="MAR04497" name="3-hydroxypropanoate:NAD+ oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:101148;PMID:10455107;PMID:15003260;PMID:4180063;PMID:4731972;PMID:5578610;PMID:9869665</p>
+            <p>AUTHORS: PMID:13672942</p>
             <p>NOTES: reaction added by gap filling</p>
           </body>
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04106">
+            <rdf:Description rdf:about="#MAR04497">
               <bqbiol:is>
                 <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/4.1.1.9"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/MCDm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R00233"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR101412"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/MCDm"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/18782"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/18781"/>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.1.1.59"/>
+                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01608"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR94902"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/r0365"/>
+                  <rdf:li rdf:resource="https://identifiers.org/rhea/13357"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02444m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02142m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02552m" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM01261m" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM01596m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00900m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039m" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02553m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR04861" sboTerm="SBO:0000185" id="MAR04861" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
@@ -503019,41 +503168,6 @@
           <speciesReference species="MAM02171e" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR04485" sboTerm="SBO:0000176" id="MAR04485" name="thymidine:phosphate deoxy-alpha-D-ribosyltransferase" reversible="true" fast="false" fbc:lowerFluxBound="FB1N1000" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>AUTHORS: PMID:15262124;PMID:15990964</p>
-            <p>NOTES: reaction added by gap filling</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR04485">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.1"/>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/2.4.2.4"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMDPP"/>
-                  <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R01570"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104887"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TMDPP"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/16040"/>
-                  <rdf:li rdf:resource="https://identifiers.org/rhea/16037"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM00639c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02997c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM02751c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02996c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR06981" sboTerm="SBO:0000176" id="MAR06981" name="4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -503067,8 +503181,11 @@
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.2.1.47"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/R_TMABADH"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/TMABADH"/>
                   <rdf:li rdf:resource="https://identifiers.org/kegg.reaction/R03283"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR108074"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR104876"/>
                   <rdf:li rdf:resource="https://identifiers.org/vmhreaction/TMABADH"/>
                   <rdf:li rdf:resource="https://identifiers.org/rhea/17985"/>
                 </rdf:Bag>
@@ -503149,38 +503266,6 @@
           <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR02380" sboTerm="SBO:0000176" id="MAR02380" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
-        <notes>
-          <body xmlns="http://www.w3.org/1999/xhtml">
-            <p>Confidence Level: 0</p>
-            <p>NOTES: reaction added by gap filling</p>
-          </body>
-        </notes>
-        <annotation>
-          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR02380">
-              <bqbiol:is>
-                <rdf:Bag>
-                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.19.-"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/HMR_2380"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/HMR_2380"/>
-                </rdf:Bag>
-              </bqbiol:is>
-            </rdf:Description>
-          </rdf:RDF>
-        </annotation>
-        <listOfReactants>
-          <speciesReference species="MAM01697c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-        </listOfReactants>
-        <listOfProducts>
-          <speciesReference species="MAM01364c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
-        </listOfProducts>
-      </reaction>
       <reaction metaid="MAR06634" sboTerm="SBO:0000176" id="MAR06634" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
@@ -503892,7 +503977,7 @@
           <speciesReference species="MAM02554c" stoichiometry="2" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR06477" sboTerm="SBO:0000176" id="MAR06477" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR06476" sboTerm="SBO:0000176" id="MAR06476" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -503902,30 +503987,30 @@
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06477">
+            <rdf:Description rdf:about="#MAR06476">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.13.30"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103665"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2387R"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2387C"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM01327r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02630r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM01327c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM02040r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02554r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM00356r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02554c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM00356c" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR06479" sboTerm="SBO:0000176" id="MAR06479" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR06478" sboTerm="SBO:0000176" id="MAR06478" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -503935,27 +504020,27 @@
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR06479">
+            <rdf:Description rdf:about="#MAR06478">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.13.30"/>
                   <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR103662"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2383R"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/RE2383C"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
-          <speciesReference species="MAM02039r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02555r" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM02630r" stoichiometry="2" constant="true"/>
-          <speciesReference species="MAM00356r" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02555c" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM02630c" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM00356c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
-          <speciesReference species="MAM00344r" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02040r" stoichiometry="3" constant="true"/>
-          <speciesReference species="MAM02554r" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM00344c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="3" constant="true"/>
+          <speciesReference species="MAM02554c" stoichiometry="2" constant="true"/>
         </listOfProducts>
       </reaction>
       <reaction metaid="MAR08614" sboTerm="SBO:0000185" id="MAR08614" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
@@ -503985,7 +504070,40 @@
           <speciesReference species="MAM01599m" stoichiometry="1" constant="true"/>
         </listOfProducts>
       </reaction>
-      <reaction metaid="MAR00149" sboTerm="SBO:0000176" id="MAR00149" name="Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -&gt; N-C18:2CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+      <reaction metaid="MAR00145" sboTerm="SBO:0000176" id="MAR00145" name="Fatty Acyl Coenzyme A Desaturase (N-C18:2CoA -&gt; N-C18:3CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
+        <notes>
+          <body xmlns="http://www.w3.org/1999/xhtml">
+            <p>Confidence Level: 0</p>
+            <p>NOTES: reaction added by gap filling</p>
+          </body>
+        </notes>
+        <annotation>
+          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+            <rdf:Description rdf:about="#MAR00145">
+              <bqbiol:is>
+                <rdf:Bag>
+                  <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.19.1"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_10"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97241"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_10"/>
+                </rdf:Bag>
+              </bqbiol:is>
+            </rdf:Description>
+          </rdf:RDF>
+        </annotation>
+        <listOfReactants>
+          <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02390c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
+        </listOfReactants>
+        <listOfProducts>
+          <speciesReference species="MAM00108c" stoichiometry="1" constant="true"/>
+          <speciesReference species="MAM02040c" stoichiometry="2" constant="true"/>
+          <speciesReference species="MAM02552c" stoichiometry="1" constant="true"/>
+        </listOfProducts>
+      </reaction>
+      <reaction metaid="MAR00151" sboTerm="SBO:0000176" id="MAR00151" name="Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -&gt; N-C18:2CoA)" reversible="false" fast="false" fbc:lowerFluxBound="FB2N0" fbc:upperFluxBound="FB3N1000">
         <notes>
           <body xmlns="http://www.w3.org/1999/xhtml">
             <p>Confidence Level: 0</p>
@@ -503994,23 +504112,23 @@
         </notes>
         <annotation>
           <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
-            <rdf:Description rdf:about="#MAR00149">
+            <rdf:Description rdf:about="#MAR00151">
               <bqbiol:is>
                 <rdf:Bag>
                   <rdf:li rdf:resource="https://identifiers.org/ec-code/1.14.99.25"/>
-                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_6"/>
-                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97246"/>
-                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_6"/>
+                  <rdf:li rdf:resource="https://identifiers.org/bigg.reaction/DESAT18_8"/>
+                  <rdf:li rdf:resource="https://identifiers.org/metanetx.reaction/MNXR97248"/>
+                  <rdf:li rdf:resource="https://identifiers.org/vmhreaction/DESAT18_8"/>
                 </rdf:Bag>
               </bqbiol:is>
             </rdf:Description>
           </rdf:RDF>
         </annotation>
         <listOfReactants>
+          <speciesReference species="MAM00057c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02039c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02553c" stoichiometry="1" constant="true"/>
           <speciesReference species="MAM02630c" stoichiometry="1" constant="true"/>
-          <speciesReference species="MAM02647c" stoichiometry="1" constant="true"/>
         </listOfReactants>
         <listOfProducts>
           <speciesReference species="MAM00106c" stoichiometry="1" constant="true"/>
@@ -504022,7 +504140,7 @@
     <fbc:listOfObjectives fbc:activeObjective="obj">
       <fbc:objective fbc:id="obj" fbc:type="maximize">
         <fbc:listOfFluxObjectives>
-          <fbc:fluxObjective fbc:reaction="MAR00021" fbc:coefficient="1"/>
+          <fbc:fluxObjective fbc:reaction="MAR13082" fbc:coefficient="1"/>
         </fbc:listOfFluxObjectives>
       </fbc:objective>
     </fbc:listOfObjectives>
@@ -504167,6 +504285,7 @@
       <fbc:geneProduct metaid="G_CG10357" sboTerm="SBO:0000243" fbc:id="G_CG10357" fbc:label="CG10357"/>
       <fbc:geneProduct metaid="G_CG10444" sboTerm="SBO:0000243" fbc:id="G_CG10444" fbc:label="CG10444"/>
       <fbc:geneProduct metaid="G_CG10467" sboTerm="SBO:0000243" fbc:id="G_CG10467" fbc:label="CG10467"/>
+      <fbc:geneProduct metaid="G_CG10483" sboTerm="SBO:0000243" fbc:id="G_CG10483" fbc:label="CG10483"/>
       <fbc:geneProduct metaid="G_CG10486" sboTerm="SBO:0000243" fbc:id="G_CG10486" fbc:label="CG10486"/>
       <fbc:geneProduct metaid="G_CG10581" sboTerm="SBO:0000243" fbc:id="G_CG10581" fbc:label="CG10581"/>
       <fbc:geneProduct metaid="G_CG10602" sboTerm="SBO:0000243" fbc:id="G_CG10602" fbc:label="CG10602"/>
@@ -504294,7 +504413,6 @@
       <fbc:geneProduct metaid="G_CG1907" sboTerm="SBO:0000243" fbc:id="G_CG1907" fbc:label="CG1907"/>
       <fbc:geneProduct metaid="G_CG1941" sboTerm="SBO:0000243" fbc:id="G_CG1941" fbc:label="CG1941"/>
       <fbc:geneProduct metaid="G_CG1946" sboTerm="SBO:0000243" fbc:id="G_CG1946" fbc:label="CG1946"/>
-      <fbc:geneProduct metaid="G_CG1983" sboTerm="SBO:0000243" fbc:id="G_CG1983" fbc:label="CG1983"/>
       <fbc:geneProduct metaid="G_CG1986" sboTerm="SBO:0000243" fbc:id="G_CG1986" fbc:label="CG1986"/>
       <fbc:geneProduct metaid="G_CG1998" sboTerm="SBO:0000243" fbc:id="G_CG1998" fbc:label="CG1998"/>
       <fbc:geneProduct metaid="G_CG2003" sboTerm="SBO:0000243" fbc:id="G_CG2003" fbc:label="CG2003"/>
@@ -504445,6 +504563,7 @@
       <fbc:geneProduct metaid="G_CG5665" sboTerm="SBO:0000243" fbc:id="G_CG5665" fbc:label="CG5665"/>
       <fbc:geneProduct metaid="G_CG5731" sboTerm="SBO:0000243" fbc:id="G_CG5731" fbc:label="CG5731"/>
       <fbc:geneProduct metaid="G_CG5757" sboTerm="SBO:0000243" fbc:id="G_CG5757" fbc:label="CG5757"/>
+      <fbc:geneProduct metaid="G_CG5793" sboTerm="SBO:0000243" fbc:id="G_CG5793" fbc:label="CG5793"/>
       <fbc:geneProduct metaid="G_CG5808" sboTerm="SBO:0000243" fbc:id="G_CG5808" fbc:label="CG5808"/>
       <fbc:geneProduct metaid="G_CG5823" sboTerm="SBO:0000243" fbc:id="G_CG5823" fbc:label="CG5823"/>
       <fbc:geneProduct metaid="G_CG5828" sboTerm="SBO:0000243" fbc:id="G_CG5828" fbc:label="CG5828"/>
@@ -504506,6 +504625,7 @@
       <fbc:geneProduct metaid="G_CG7402" sboTerm="SBO:0000243" fbc:id="G_CG7402" fbc:label="CG7402"/>
       <fbc:geneProduct metaid="G_CG7430" sboTerm="SBO:0000243" fbc:id="G_CG7430" fbc:label="CG7430"/>
       <fbc:geneProduct metaid="G_CG7458" sboTerm="SBO:0000243" fbc:id="G_CG7458" fbc:label="CG7458"/>
+      <fbc:geneProduct metaid="G_CG7536" sboTerm="SBO:0000243" fbc:id="G_CG7536" fbc:label="CG7536"/>
       <fbc:geneProduct metaid="G_CG7550" sboTerm="SBO:0000243" fbc:id="G_CG7550" fbc:label="CG7550"/>
       <fbc:geneProduct metaid="G_CG7551" sboTerm="SBO:0000243" fbc:id="G_CG7551" fbc:label="CG7551"/>
       <fbc:geneProduct metaid="G_CG7560" sboTerm="SBO:0000243" fbc:id="G_CG7560" fbc:label="CG7560"/>
@@ -505823,7 +505943,6 @@
           <groups:member groups:idRef="MAR03822"/>
           <groups:member groups:idRef="MAR03827"/>
           <groups:member groups:idRef="MAR03829"/>
-          <groups:member groups:idRef="MAR03831"/>
           <groups:member groups:idRef="MAR03862"/>
           <groups:member groups:idRef="MAR03865"/>
           <groups:member groups:idRef="MAR03890"/>
@@ -505848,6 +505967,8 @@
           <groups:member groups:idRef="MAR07642"/>
           <groups:member groups:idRef="MAR04285"/>
           <groups:member groups:idRef="MAR11565"/>
+          <groups:member groups:idRef="MAR20071"/>
+          <groups:member groups:idRef="MAR20072"/>
           <groups:member groups:idRef="MAR15017"/>
         </groups:listOfMembers>
       </groups:group>
@@ -506880,7 +507001,6 @@
           <groups:member groups:idRef="MAR08663"/>
           <groups:member groups:idRef="MAR08664"/>
           <groups:member groups:idRef="MAR08665"/>
-          <groups:member groups:idRef="MAR08666"/>
           <groups:member groups:idRef="MAR08667"/>
           <groups:member groups:idRef="MAR08668"/>
           <groups:member groups:idRef="MAR08669"/>
@@ -507286,15 +507406,15 @@
           <groups:member groups:idRef="MAR09947"/>
           <groups:member groups:idRef="MAR11408"/>
           <groups:member groups:idRef="MAR11506"/>
-          <groups:member groups:idRef="MAR00114"/>
-          <groups:member groups:idRef="MAR00118"/>
+          <groups:member groups:idRef="MAR00113"/>
+          <groups:member groups:idRef="MAR00222"/>
+          <groups:member groups:idRef="MAR00443"/>
           <groups:member groups:idRef="MAR01498"/>
-          <groups:member groups:idRef="MAR01510"/>
+          <groups:member groups:idRef="MAR01508"/>
           <groups:member groups:idRef="MAR01714"/>
           <groups:member groups:idRef="MAR01715"/>
           <groups:member groups:idRef="MAR02200"/>
-          <groups:member groups:idRef="MAR02337"/>
-          <groups:member groups:idRef="MAR02339"/>
+          <groups:member groups:idRef="MAR02301"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group42" groups:name="Chondroitin / heparan sulfate biosynthesis" groups:kind="partonomy">
@@ -509766,7 +509886,6 @@
           <groups:member groups:idRef="MAR13063"/>
           <groups:member groups:idRef="MAR13064"/>
           <groups:member groups:idRef="MAR13065"/>
-          <groups:member groups:idRef="MAR13066"/>
           <groups:member groups:idRef="MAR13067"/>
           <groups:member groups:idRef="MAR13068"/>
           <groups:member groups:idRef="MAR13069"/>
@@ -509983,7 +510102,8 @@
           <groups:member groups:idRef="MAR03745"/>
           <groups:member groups:idRef="MAR03749"/>
           <groups:member groups:idRef="MAR11305"/>
-          <groups:member groups:idRef="MAR00149"/>
+          <groups:member groups:idRef="MAR00145"/>
+          <groups:member groups:idRef="MAR00151"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group54" groups:name="Fatty acid biosynthesis (even-chain)" groups:kind="partonomy">
@@ -510159,7 +510279,6 @@
           <groups:member groups:idRef="MAR20049"/>
           <groups:member groups:idRef="MAR20050"/>
           <groups:member groups:idRef="MAR20051"/>
-          <groups:member groups:idRef="MAR20052"/>
           <groups:member groups:idRef="MAR20053"/>
           <groups:member groups:idRef="MAR20054"/>
           <groups:member groups:idRef="MAR20055"/>
@@ -510198,8 +510317,6 @@
           <groups:member groups:idRef="MAR00452"/>
           <groups:member groups:idRef="MAR00455"/>
           <groups:member groups:idRef="MAR00465"/>
-          <groups:member groups:idRef="MAR00562"/>
-          <groups:member groups:idRef="MAR00563"/>
           <groups:member groups:idRef="MAR00727"/>
           <groups:member groups:idRef="MAR00728"/>
           <groups:member groups:idRef="MAR00737"/>
@@ -510393,7 +510510,6 @@
           <groups:member groups:idRef="MAR04511"/>
           <groups:member groups:idRef="MAR04515"/>
           <groups:member groups:idRef="MAR04522"/>
-          <groups:member groups:idRef="MAR04562"/>
           <groups:member groups:idRef="MAR04566"/>
           <groups:member groups:idRef="MAR04569"/>
           <groups:member groups:idRef="MAR04571"/>
@@ -510530,7 +510646,6 @@
           <groups:member groups:idRef="MAR05421"/>
           <groups:member groups:idRef="MAR05428"/>
           <groups:member groups:idRef="MAR05431"/>
-          <groups:member groups:idRef="MAR05434"/>
           <groups:member groups:idRef="MAR05449"/>
           <groups:member groups:idRef="MAR05456"/>
           <groups:member groups:idRef="MAR05988"/>
@@ -510600,7 +510715,6 @@
           <groups:member groups:idRef="MAR09950"/>
           <groups:member groups:idRef="MAR10374"/>
           <groups:member groups:idRef="MAR10377"/>
-          <groups:member groups:idRef="MAR11310"/>
           <groups:member groups:idRef="MAR11529"/>
           <groups:member groups:idRef="MAR11530"/>
           <groups:member groups:idRef="MAR11534"/>
@@ -511211,6 +511325,7 @@
           <groups:member groups:idRef="MAR04368"/>
           <groups:member groups:idRef="MAR04370"/>
           <groups:member groups:idRef="MAR04371"/>
+          <groups:member groups:idRef="MAR04372"/>
           <groups:member groups:idRef="MAR04373"/>
           <groups:member groups:idRef="MAR04375"/>
           <groups:member groups:idRef="MAR04377"/>
@@ -511664,7 +511779,12 @@
           <groups:member groups:idRef="MAR20010"/>
           <groups:member groups:idRef="MAR20013"/>
           <groups:member groups:idRef="MAR20044"/>
-          <groups:member groups:idRef="MAR20045"/>
+          <groups:member groups:idRef="MAR20099"/>
+          <groups:member groups:idRef="MAR20100"/>
+          <groups:member groups:idRef="MAR20102"/>
+          <groups:member groups:idRef="MAR20103"/>
+          <groups:member groups:idRef="MAR20104"/>
+          <groups:member groups:idRef="MAR20105"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group89" groups:name="Keratan sulfate biosynthesis" groups:kind="partonomy">
@@ -512076,13 +512196,8 @@
           <groups:member groups:idRef="MAR05127"/>
           <groups:member groups:idRef="MAR05128"/>
           <groups:member groups:idRef="MAR05363"/>
-          <groups:member groups:idRef="MAR05406"/>
-          <groups:member groups:idRef="MAR05409"/>
           <groups:member groups:idRef="MAR07794"/>
           <groups:member groups:idRef="MAR08617"/>
-          <groups:member groups:idRef="MAR08749"/>
-          <groups:member groups:idRef="MAR08750"/>
-          <groups:member groups:idRef="MAR08751"/>
           <groups:member groups:idRef="MAR08752"/>
           <groups:member groups:idRef="MAR07741"/>
           <groups:member groups:idRef="MAR02126"/>
@@ -512145,6 +512260,7 @@
           <groups:member groups:idRef="MAR11430"/>
           <groups:member groups:idRef="MAR12126"/>
           <groups:member groups:idRef="MAR10070"/>
+          <groups:member groups:idRef="MAR20110"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group97" groups:name="N-glycan metabolism" groups:kind="partonomy">
@@ -512517,7 +512633,6 @@
           <groups:member groups:idRef="MAR03469"/>
           <groups:member groups:idRef="MAR03470"/>
           <groups:member groups:idRef="MAR03472"/>
-          <groups:member groups:idRef="MAR02380"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group103" groups:name="Oxidative phosphorylation" groups:kind="partonomy">
@@ -512610,8 +512725,6 @@
           <groups:member groups:idRef="MAR08074"/>
           <groups:member groups:idRef="MAR08653"/>
           <groups:member groups:idRef="MAR08971"/>
-          <groups:member groups:idRef="MAR08985"/>
-          <groups:member groups:idRef="MAR08992"/>
           <groups:member groups:idRef="MAR09992"/>
           <groups:member groups:idRef="MAR11413"/>
         </groups:listOfMembers>
@@ -513077,6 +513190,9 @@
           <groups:member groups:idRef="MAR08634"/>
           <groups:member groups:idRef="MAR09717"/>
           <groups:member groups:idRef="MAR01044"/>
+          <groups:member groups:idRef="MAR20090"/>
+          <groups:member groups:idRef="MAR20091"/>
+          <groups:member groups:idRef="MAR20092"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group114" groups:name="Propanoate metabolism" groups:kind="partonomy">
@@ -513100,7 +513216,7 @@
           <groups:member groups:idRef="MAR11486"/>
           <groups:member groups:idRef="MAR11487"/>
           <groups:member groups:idRef="MAR11489"/>
-          <groups:member groups:idRef="MAR04106"/>
+          <groups:member groups:idRef="MAR04497"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group115" groups:name="Prostaglandin biosynthesis" groups:kind="partonomy">
@@ -513410,11 +513526,9 @@
           <groups:member groups:idRef="MAR08637"/>
           <groups:member groups:idRef="MAR00096"/>
           <groups:member groups:idRef="MAR02120"/>
-          <groups:member groups:idRef="MAR02490"/>
           <groups:member groups:idRef="MAR08274"/>
           <groups:member groups:idRef="MAR11398"/>
           <groups:member groups:idRef="MAR15013"/>
-          <groups:member groups:idRef="MAR04485"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group121" groups:name="Pyruvate metabolism" groups:kind="partonomy">
@@ -513527,7 +513641,6 @@
           <groups:member groups:idRef="MAR20001"/>
           <groups:member groups:idRef="MAR20002"/>
           <groups:member groups:idRef="MAR20003"/>
-          <groups:member groups:idRef="MAR20004"/>
           <groups:member groups:idRef="MAR20005"/>
           <groups:member groups:idRef="MAR20006"/>
           <groups:member groups:idRef="MAR20007"/>
@@ -513771,6 +513884,7 @@
           <groups:member groups:idRef="MAR07167"/>
           <groups:member groups:idRef="MAR07168"/>
           <groups:member groups:idRef="MAR07169"/>
+          <groups:member groups:idRef="MAR20098"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group131" groups:name="Thiamine metabolism" groups:kind="partonomy">
@@ -514073,7 +514187,6 @@
           <groups:member groups:idRef="MAR05240"/>
           <groups:member groups:idRef="MAR05241"/>
           <groups:member groups:idRef="MAR05246"/>
-          <groups:member groups:idRef="MAR05295"/>
           <groups:member groups:idRef="MAR05296"/>
           <groups:member groups:idRef="MAR05303"/>
           <groups:member groups:idRef="MAR05305"/>
@@ -514092,8 +514205,6 @@
           <groups:member groups:idRef="MAR05328"/>
           <groups:member groups:idRef="MAR05330"/>
           <groups:member groups:idRef="MAR05332"/>
-          <groups:member groups:idRef="MAR05333"/>
-          <groups:member groups:idRef="MAR05413"/>
           <groups:member groups:idRef="MAR05429"/>
           <groups:member groups:idRef="MAR05430"/>
           <groups:member groups:idRef="MAR05432"/>
@@ -514954,11 +515065,7 @@
           <groups:member groups:idRef="MAR06375"/>
           <groups:member groups:idRef="MAR06377"/>
           <groups:member groups:idRef="MAR06379"/>
-          <groups:member groups:idRef="MAR06380"/>
-          <groups:member groups:idRef="MAR06381"/>
-          <groups:member groups:idRef="MAR06382"/>
           <groups:member groups:idRef="MAR06383"/>
-          <groups:member groups:idRef="MAR06384"/>
           <groups:member groups:idRef="MAR06392"/>
           <groups:member groups:idRef="MAR06406"/>
           <groups:member groups:idRef="MAR06424"/>
@@ -516114,7 +516221,6 @@
           <groups:member groups:idRef="MAR01809"/>
           <groups:member groups:idRef="MAR00020"/>
           <groups:member groups:idRef="MAR00462"/>
-          <groups:member groups:idRef="MAR00464"/>
           <groups:member groups:idRef="MAR00466"/>
           <groups:member groups:idRef="MAR00467"/>
           <groups:member groups:idRef="MAR00664"/>
@@ -516494,7 +516600,6 @@
           <groups:member groups:idRef="MAR02477"/>
           <groups:member groups:idRef="MAR02479"/>
           <groups:member groups:idRef="MAR02481"/>
-          <groups:member groups:idRef="MAR04411"/>
           <groups:member groups:idRef="MAR04645"/>
           <groups:member groups:idRef="MAR04674"/>
           <groups:member groups:idRef="MAR04677"/>
@@ -516840,7 +516945,6 @@
           <groups:member groups:idRef="MAR10407"/>
           <groups:member groups:idRef="MAR10408"/>
           <groups:member groups:idRef="MAR10409"/>
-          <groups:member groups:idRef="MAR10410"/>
           <groups:member groups:idRef="MAR10411"/>
           <groups:member groups:idRef="MAR10413"/>
           <groups:member groups:idRef="MAR10414"/>
@@ -517877,6 +517981,7 @@
           <groups:member groups:idRef="MAR03124"/>
           <groups:member groups:idRef="MAR03168"/>
           <groups:member groups:idRef="MAR03255"/>
+          <groups:member groups:idRef="MAR20089"/>
         </groups:listOfMembers>
       </groups:group>
       <groups:group sboTerm="SBO:0000633" groups:id="group138" groups:name="Tyrosine metabolism" groups:kind="partonomy">
@@ -517937,7 +518042,15 @@
           <groups:member groups:idRef="MAR15054"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group139" groups:name="Ubiquinone synthesis" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group139" groups:name="Ubiquinone and other terpenoid-quinone biosynthesis" groups:kind="partonomy">
+        <groups:listOfMembers>
+          <groups:member groups:idRef="MAR20106"/>
+          <groups:member groups:idRef="MAR20107"/>
+          <groups:member groups:idRef="MAR20108"/>
+          <groups:member groups:idRef="MAR20109"/>
+        </groups:listOfMembers>
+      </groups:group>
+      <groups:group sboTerm="SBO:0000633" groups:id="group140" groups:name="Ubiquinone synthesis" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR00040"/>
           <groups:member groups:idRef="MAR00041"/>
@@ -517951,12 +518064,12 @@
           <groups:member groups:idRef="MAR01724"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group140" groups:name="Urea cycle" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group141" groups:name="Urea cycle" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR02527"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group141" groups:name="Valine, leucine, and isoleucine metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group142" groups:name="Valine, leucine, and isoleucine metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR03206"/>
           <groups:member groups:idRef="MAR03211"/>
@@ -518011,7 +518124,7 @@
           <groups:member groups:idRef="MAR11525"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group142" groups:name="Vitamin A metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group143" groups:name="Vitamin A metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR01506"/>
           <groups:member groups:idRef="MAR01507"/>
@@ -518024,7 +518137,7 @@
           <groups:member groups:idRef="MAR03131"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group143" groups:name="Vitamin B12 metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group144" groups:name="Vitamin B12 metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR08613"/>
           <groups:member groups:idRef="MAR03138"/>
@@ -518032,7 +518145,7 @@
           <groups:member groups:idRef="MAR08616"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group144" groups:name="Vitamin B6 metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group145" groups:name="Vitamin B6 metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR04064"/>
           <groups:member groups:idRef="MAR04065"/>
@@ -518047,13 +518160,13 @@
           <groups:member groups:idRef="MAR08725"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group145" groups:name="Vitamin C metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group146" groups:name="Vitamin C metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR01372"/>
           <groups:member groups:idRef="MAR03265"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group146" groups:name="Vitamin D metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group147" groups:name="Vitamin D metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR02114"/>
           <groups:member groups:idRef="MAR02115"/>
@@ -518091,7 +518204,7 @@
           <groups:member groups:idRef="MAR03436"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group147" groups:name="Vitamin E metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group148" groups:name="Vitamin E metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR06423"/>
           <groups:member groups:idRef="MAR06432"/>
@@ -518130,11 +518243,11 @@
           <groups:member groups:idRef="MAR04007"/>
           <groups:member groups:idRef="MAR06464"/>
           <groups:member groups:idRef="MAR06466"/>
-          <groups:member groups:idRef="MAR06477"/>
-          <groups:member groups:idRef="MAR06479"/>
+          <groups:member groups:idRef="MAR06476"/>
+          <groups:member groups:idRef="MAR06478"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group148" groups:name="Xenobiotics metabolism" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group149" groups:name="Xenobiotics metabolism" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR06992"/>
           <groups:member groups:idRef="MAR06993"/>
@@ -518271,7 +518384,7 @@
           <groups:member groups:idRef="MAR12977"/>
         </groups:listOfMembers>
       </groups:group>
-      <groups:group sboTerm="SBO:0000633" groups:id="group149" groups:name="octane oxidation" groups:kind="partonomy">
+      <groups:group sboTerm="SBO:0000633" groups:id="group150" groups:name="octane oxidation" groups:kind="partonomy">
         <groups:listOfMembers>
           <groups:member groups:idRef="MAR20017"/>
           <groups:member groups:idRef="MAR20061"/>
diff --git a/model/Fruitfly-GEM.yml b/model/Fruitfly-GEM.yml
index a7f80a4..ddc3cc3 100644
--- a/model/Fruitfly-GEM.yml
+++ b/model/Fruitfly-GEM.yml
@@ -3,8 +3,8 @@
 - metaData:
     short_name: "Fruitfly-GEM"
     full_name: ""
-    version: "1.4.0"
-    date: "2023-05-16"
+    version: ""
+    date: "2023-08-16"
     taxonomy: ""
     github: ""
     description: ""
@@ -15584,27 +15584,6 @@
       - formula: "CH2NO5P"
       - charge: -2
       - inchis: ""
-    - !!omap
-      - id: "MAM01421c"
-      - name: "carbonate"
-      - compartment: "c"
-      - formula: "CH2O3"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01421m"
-      - name: "carbonate"
-      - compartment: "m"
-      - formula: "CH2O3"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM01421e"
-      - name: "carbonate"
-      - compartment: "e"
-      - formula: "CH2O3"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM01422c"
       - name: "carboxybiotin-carboxyl-carrier"
@@ -28373,30 +28352,37 @@
       - formula: "C14H22N2O10PRS"
       - charge: -2
       - inchis: ""
+    - !!omap
+      - id: "MAM02443e"
+      - name: "malonyl-carnitine"
+      - compartment: "e"
+      - formula: "C10H16NO6"
+      - charge: -1
+      - inchis: ""
     - !!omap
       - id: "MAM02443c"
-      - name: "malonyl-carnitin"
+      - name: "malonyl-carnitine"
       - compartment: "c"
       - formula: "C10H16NO6"
       - charge: -1
       - inchis: ""
     - !!omap
       - id: "MAM02443m"
-      - name: "malonyl-carnitin"
+      - name: "malonyl-carnitine"
       - compartment: "m"
       - formula: "C10H16NO6"
       - charge: -1
       - inchis: ""
     - !!omap
       - id: "MAM02443x"
-      - name: "malonyl-carnitin"
+      - name: "malonyl-carnitine"
       - compartment: "x"
       - formula: "C10H16NO6"
       - charge: -1
       - inchis: ""
     - !!omap
       - id: "MAM02443r"
-      - name: "malonyl-carnitin"
+      - name: "malonyl-carnitine"
       - compartment: "r"
       - formula: "C10H16NO6"
       - charge: -1
@@ -38047,20 +38033,6 @@
       - formula: "C24H42O21"
       - charge: 0
       - inchis: ""
-    - !!omap
-      - id: "MAM03573m"
-      - name: "Electron Transfer Flavoprotein Oxidized"
-      - compartment: "m"
-      - formula: "R"
-      - charge: 0
-      - inchis: ""
-    - !!omap
-      - id: "MAM03574m"
-      - name: "Electron Transfer Flavoprotein Reduced"
-      - compartment: "m"
-      - formula: "RH2"
-      - charge: 0
-      - inchis: ""
     - !!omap
       - id: "MAM01893e"
       - name: "1-Acyl Phosphoglycerol"
@@ -41939,20 +41911,6 @@
       - formula: "C25H49NO5"
       - charge: 0
       - inchis: "InChI=1/C25H49NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(27)19-25(30)31-23(20-24(28)29)21-26(2,3)4/h22-23,27H,5-21H2,1-4H3"
-    - !!omap
-      - id: "MAM03494c"
-      - name: "Malonyl Carnitine"
-      - compartment: "c"
-      - formula: "C10H16NO6"
-      - charge: -1
-      - inchis: ""
-    - !!omap
-      - id: "MAM03494e"
-      - name: "Malonyl Carnitine"
-      - compartment: "e"
-      - formula: "C10H16NO6"
-      - charge: -1
-      - inchis: ""
     - !!omap
       - id: "MAM02635e"
       - name: "O-butanoylcarnitine"
@@ -56653,6 +56611,265 @@
       - formula: "C15H23O2"
       - charge: 0
       - inchis: ""
+    - !!omap
+      - id: "MAM20061c"
+      - name: "epsilon-(gamma-L-Glutamyl)-L-lysine"
+      - compartment: "c"
+      - formula: "C11H21N3O5"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20061n"
+      - name: "epsilon-(gamma-L-Glutamyl)-L-lysine"
+      - compartment: "n"
+      - formula: "C11H21N3O5"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM01127n"
+      - name: "5-oxoproline"
+      - compartment: "n"
+      - formula: "C5H6NO3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM01806m"
+      - name: "farnesyl-PP"
+      - compartment: "m"
+      - formula: "C15H25O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM20064m"
+      - name: "Fe(II)-heme o"
+      - compartment: "m"
+      - formula: "C49H56FeN4O5"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM20064c"
+      - name: "Fe(II)-heme o"
+      - compartment: "c"
+      - formula: "C49H56FeN4O5"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM01806n"
+      - name: "farnesyl-PP"
+      - compartment: "n"
+      - formula: "C15H25O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM02049n"
+      - name: "heme"
+      - compartment: "n"
+      - formula: "C34H30FeN4O4"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM20064n"
+      - name: "Fe(II)-heme o"
+      - compartment: "n"
+      - formula: "C49H56FeN4O5"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM01657r"
+      - name: "dehydrodolichol-diphosphate"
+      - compartment: "r"
+      - formula: "C100H161O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM01252n"
+      - name: "acetate"
+      - compartment: "n"
+      - formula: "C2H3O2"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM01288n"
+      - name: "ADP-ribose"
+      - compartment: "n"
+      - formula: "C15H21N5O14P2"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM20077n"
+      - name: "2-O-acetyl-ADP-D-ribose"
+      - compartment: "n"
+      - formula: "C17H23N5O15P2"
+      - charge: -2
+      - inchis: ""
+    - !!omap
+      - id: "MAM02583n"
+      - name: "nicotinamide"
+      - compartment: "n"
+      - formula: "C6H6N2O"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20063n"
+      - name: "alpha-NAD(+)"
+      - compartment: "n"
+      - formula: "C21H26N7O14P2"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM20066c"
+      - name: "menaquinol-4"
+      - compartment: "c"
+      - formula: "C31H42O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20065c"
+      - name: "menadiol"
+      - compartment: "c"
+      - formula: "C11H10O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20066r"
+      - name: "menaquinol-4"
+      - compartment: "r"
+      - formula: "C31H42O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM03590r"
+      - name: "2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate"
+      - compartment: "r"
+      - formula: "C20H33O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM20065r"
+      - name: "menadiol"
+      - compartment: "r"
+      - formula: "C11H10O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20066g"
+      - name: "menaquinol-4"
+      - compartment: "g"
+      - formula: "C31H42O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM02759g"
+      - name: "PPi"
+      - compartment: "g"
+      - formula: "HO7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM03590g"
+      - name: "2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate"
+      - compartment: "g"
+      - formula: "C20H33O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM20065g"
+      - name: "menadiol"
+      - compartment: "g"
+      - formula: "C11H10O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM20066n"
+      - name: "menaquinol-4"
+      - compartment: "n"
+      - formula: "C31H42O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM03590n"
+      - name: "2-Trans,6-Trans,10-Trans-Geranylgeranyl Diphosphate"
+      - compartment: "n"
+      - formula: "C20H33O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM20065n"
+      - name: "menadiol"
+      - compartment: "n"
+      - formula: "C11H10O2"
+      - charge: 0
+      - inchis: ""
+    - !!omap
+      - id: "MAM00767c"
+      - name: "3-decaprenyl-4-hydroxybenzoate"
+      - compartment: "c"
+      - formula: "C57H85O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM00995r"
+      - name: "4-hydroxybenzoate"
+      - compartment: "r"
+      - formula: "C7H5O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM01316r"
+      - name: "all-trans-decaprenyl-diphosphate"
+      - compartment: "r"
+      - formula: "C50H81O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM00767r"
+      - name: "3-decaprenyl-4-hydroxybenzoate"
+      - compartment: "r"
+      - formula: "C57H85O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM00995g"
+      - name: "4-hydroxybenzoate"
+      - compartment: "g"
+      - formula: "C7H5O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM01316g"
+      - name: "all-trans-decaprenyl-diphosphate"
+      - compartment: "g"
+      - formula: "C50H81O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM00767g"
+      - name: "3-decaprenyl-4-hydroxybenzoate"
+      - compartment: "g"
+      - formula: "C57H85O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM00995n"
+      - name: "4-hydroxybenzoate"
+      - compartment: "n"
+      - formula: "C7H5O3"
+      - charge: -1
+      - inchis: ""
+    - !!omap
+      - id: "MAM01316n"
+      - name: "all-trans-decaprenyl-diphosphate"
+      - compartment: "n"
+      - formula: "C50H81O7P2"
+      - charge: -3
+      - inchis: ""
+    - !!omap
+      - id: "MAM00767n"
+      - name: "3-decaprenyl-4-hydroxybenzoate"
+      - compartment: "n"
+      - formula: "C57H85O3"
+      - charge: -1
+      - inchis: ""
     - !!omap
       - id: "MAM15003c"
       - name: "L-Allothreonine"
@@ -56906,12 +57123,12 @@
       - charge: 0
       - inchis: "InChI=1S/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23+,24?,27-,28+/m1/s1"
     - !!omap
-      - id: "MAM01449r"
-      - name: "cholestenol"
+      - id: "MAM01066r"
+      - name: "5alpha-cholesta-7,24-dien-3beta-ol"
       - compartment: "r"
-      - formula: "C27H46O"
+      - formula: "C27H44O"
       - charge: 0
-      - inchis: "InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1"
+      - inchis: "InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1"
     - !!omap
       - id: "MAM02932r"
       - name: "squalene 2,3-oxide"
@@ -56920,9 +57137,9 @@
       - charge: 0
       - inchis: "InChI=1/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/t29-/s2"
     - !!omap
-      - id: "MAM00356r"
+      - id: "MAM00356c"
       - name: "13-hydroxy-alpha-tocopherol"
-      - compartment: "r"
+      - compartment: "c"
       - formula: "C29H50O3"
       - charge: 0
       - inchis: ""
@@ -57291,6 +57508,23 @@
       - subsystem:
           - "Glycolysis / Gluconeogenesis"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR04372"
+      - name: "2,3-bisphospho-D-glycerate 2-phosphohydrolase"
+      - metabolites: !!omap
+          - MAM00569c: -1
+          - MAM00913c: 1
+          - MAM02040c: -1
+          - MAM02751c: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "CG18371 or CG34161"
+      - rxnNotes: ""
+      - eccodes: "3.1.3.13"
+      - references: ""
+      - subsystem:
+          - "Glycolysis / Gluconeogenesis"
+      - confidence_score: 0
     - !!omap
       - id: "MAR04373"
       - name: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)"
@@ -59504,13 +59738,13 @@
       - id: "MAR03797"
       - name: "Propanoate:CoA ligase (AMP-forming)"
       - metabolites: !!omap
-          - MAM01334m: -1
-          - MAM01371m: 1
-          - MAM01597m: 1
-          - MAM02759m: -1
-          - MAM02772m: 1
-          - MAM02774m: -1
-      - lower_bound: -1000
+          - MAM01334m: 1
+          - MAM01371m: -1
+          - MAM01597m: -1
+          - MAM02759m: 1
+          - MAM02772m: -1
+          - MAM02774m: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "AcCoAS or CG6432"
       - rxnNotes: ""
@@ -59602,7 +59836,7 @@
           - MAM02759m: 1
           - MAM02772m: -1
           - MAM02775m: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "AcCoAS or CG6432"
       - rxnNotes: ""
@@ -60480,11 +60714,11 @@
       - id: "MAR04085"
       - name: "AMP:diphosphate phospho-D-ribosyltransferase"
       - metabolites: !!omap
-          - MAM01279c: 1
-          - MAM01334c: -1
-          - MAM02759c: -1
-          - MAM02806c: 1
-      - lower_bound: -1000
+          - MAM01279c: -1
+          - MAM01334c: 1
+          - MAM02759c: 1
+          - MAM02806c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Aprt"
       - rxnNotes: ""
@@ -60497,11 +60731,11 @@
       - id: "MAR04086"
       - name: "AMP:diphosphate phospho-D-ribosyltransferase"
       - metabolites: !!omap
-          - MAM01279e: 1
-          - MAM01334e: -1
-          - MAM02759e: -1
-          - MAM02806e: 1
-      - lower_bound: -1000
+          - MAM01279e: -1
+          - MAM01334e: 1
+          - MAM02759e: 1
+          - MAM02806e: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Aprt"
       - rxnNotes: ""
@@ -62548,11 +62782,11 @@
       - id: "MAR04577"
       - name: "Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase"
       - metabolites: !!omap
-          - MAM02659c: 1
-          - MAM02660c: -1
-          - MAM02759c: -1
-          - MAM02806c: 1
-      - lower_bound: -1000
+          - MAM02659c: -1
+          - MAM02660c: 1
+          - MAM02759c: 1
+          - MAM02806c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "r-l"
       - rxnNotes: ""
@@ -64958,23 +65192,6 @@
       - subsystem:
           - "Alanine, aspartate and glutamate metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR03831"
-      - name: "L-aspartate ammonia-lyase (fumarate-forming)"
-      - metabolites: !!omap
-          - MAM01370c: -1
-          - MAM01862c: 1
-          - MAM02039c: 1
-          - MAM02578c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Fum1"
-      - rxnNotes: ""
-      - eccodes: "4.3.1.1"
-      - references: ""
-      - subsystem:
-          - "Alanine, aspartate and glutamate metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR03862"
       - name: "L-asparagine amidohydrolase"
@@ -65306,7 +65523,7 @@
           - MAM01931c: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG32196 or CG4306 or Tina-1"
+      - gene_reaction_rule: "CG32196 or CG4306"
       - rxnNotes: ""
       - eccodes: "2.3.2.4"
       - references: "PMID:2570694;PMID:6150932"
@@ -65322,7 +65539,7 @@
           - MAM02026c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG32196 or CG4306 or Tina-1"
+      - gene_reaction_rule: "CG32196 or CG4306"
       - rxnNotes: ""
       - eccodes: "2.3.2.4"
       - references: "PMID:2570694;PMID:6150932"
@@ -65357,7 +65574,7 @@
           - MAM01638c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG1983"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -65585,7 +65802,7 @@
           - MAM02039m: 1
           - MAM02040m: -1
           - MAM02046m: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: "CAH1"
       - rxnNotes: ""
@@ -71239,7 +71456,7 @@
           - MAM02986c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG17691 or CG7430 or CG8199 or Prx6a or Pxn"
+      - gene_reaction_rule: "Prx6a or Pxn"
       - rxnNotes: ""
       - eccodes: "1.11.1.7;1.2.4.4;1.8.1.4"
       - references: ""
@@ -72725,11 +72942,11 @@
       - id: "MAR04532"
       - name: "CTP:N-glycoloylneuraminate cytidylyltransferase"
       - metabolites: !!omap
-          - MAM01593c: -1
-          - MAM01623c: 1
-          - MAM02565c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01593c: 1
+          - MAM01623c: -1
+          - MAM02565c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Csas"
       - rxnNotes: ""
@@ -72782,11 +72999,11 @@
       - id: "MAR04536"
       - name: "CTP:N-acetylneuraminate cytidylyltransferase"
       - metabolites: !!omap
-          - MAM01592n: -1
-          - MAM01623n: 1
-          - MAM02543n: 1
-          - MAM02759n: -1
-      - lower_bound: -1000
+          - MAM01592n: 1
+          - MAM01623n: -1
+          - MAM02543n: -1
+          - MAM02759n: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Csas"
       - rxnNotes: ""
@@ -73682,11 +73899,11 @@
       - id: "MAR01532"
       - name: ""
       - metabolites: !!omap
-          - MAM01706c: 1
-          - MAM01806c: 1
-          - MAM02759c: -1
-          - MAM03026c: -1
-      - lower_bound: -1000
+          - MAM01706c: -1
+          - MAM01806c: -1
+          - MAM02759c: 1
+          - MAM03026c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Fpps or qm"
       - rxnNotes: ""
@@ -77379,12 +77596,13 @@
       - id: "MAR05407"
       - name: "carbonate hydro-lyase (carbon-dioxide-forming)"
       - metabolites: !!omap
-          - MAM01421e: 1
           - MAM01596e: -1
+          - MAM02039e: 1
           - MAM02040e: -1
+          - MAM02046e: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "APP-BP1 or CAH1 or CAH16 or CAH2 or CAH4 or CAH5 or CAH6 or CAH7 or CAH9"
+      - gene_reaction_rule: "CAH1 or CAH16 or CAH2 or CAH4 or CAH5 or CAH6 or CAH7 or CAH9"
       - rxnNotes: ""
       - eccodes: "4.2.1.1"
       - references: "PMID:10938543;PMID:11493685;PMID:12713833;PMID:12747791;PMID:14640555;PMID:17259996;PMID:17504134;PMID:17826101;PMID:7011879;PMID:7672338"
@@ -77593,15 +77811,15 @@
       - id: "MAR08664"
       - name: "(3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)"
       - metabolites: !!omap
-          - MAM00084m: -1
-          - MAM02040m: 1
-          - MAM02192m: 1
-      - lower_bound: -1000
+          - MAM00084m: 1
+          - MAM02040m: -1
+          - MAM02192m: -1
+      - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG8778"
       - rxnNotes: ""
       - eccodes: "4.2.1.56"
-      - references: ""
+      - references: "PMID:29056341"
       - subsystem:
           - "C5-branched dibasic acid metabolism"
       - confidence_score: 0
@@ -77621,22 +77839,6 @@
       - subsystem:
           - "C5-branched dibasic acid metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR08666"
-      - name: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)"
-      - metabolites: !!omap
-          - MAM00084m: -1
-          - MAM01261m: 1
-          - MAM02819m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "4.1.3.25"
-      - references: ""
-      - subsystem:
-          - "C5-branched dibasic acid metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR08667"
       - name: ""
@@ -78317,10 +78519,10 @@
           - MAM03103m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "SdhA and SdhB and SdhC and SdhD"
+      - gene_reaction_rule: "CG12398 or CG9514 or CG9519 or CG9521 or Dhod or Etf-QO or Etfb or Gld or Gpo1 or slgA or wal"
       - rxnNotes: ""
       - eccodes: "1.5.5.1"
-      - references: ""
+      - references: "PMID:34428349"
       - subsystem:
           - "Oxidative phosphorylation"
       - confidence_score: 0
@@ -78569,13 +78771,13 @@
       - id: "MAR00188"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02344c: 1
-          - MAM02345c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02344c: -1
+          - MAM02345c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78588,13 +78790,13 @@
       - id: "MAR00192"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-          - MAM03050c: -1
-          - MAM03051c: 1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+          - MAM03050c: 1
+          - MAM03051c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78607,13 +78809,13 @@
       - id: "MAR00196"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02494c: 1
-          - MAM02495c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02494c: -1
+          - MAM02495c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78632,7 +78834,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78651,7 +78853,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78664,13 +78866,13 @@
       - id: "MAR00209"
       - name: ""
       - metabolites: !!omap
-          - MAM01141c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02745c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01141c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02745c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78683,13 +78885,13 @@
       - id: "MAR00213"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02689c: -1
-          - MAM02690c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02689c: 1
+          - MAM02690c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78702,13 +78904,13 @@
       - id: "MAR00217"
       - name: "Palmitate:CoA ligase (AMP-forming)"
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02674c: 1
-          - MAM02678c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02674c: -1
+          - MAM02678c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78721,13 +78923,13 @@
       - id: "MAR00226"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02675c: 1
-          - MAM02677c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02675c: -1
+          - MAM02677c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78740,13 +78942,13 @@
       - id: "MAR00233"
       - name: ""
       - metabolites: !!omap
-          - MAM01191c: -1
-          - MAM01197c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01191c: 1
+          - MAM01197c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78759,13 +78961,13 @@
       - id: "MAR00237"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02101c: -1
-          - MAM02456c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02101c: 1
+          - MAM02456c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78784,7 +78986,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78797,13 +78999,13 @@
       - id: "MAR00245"
       - name: ""
       - metabolites: !!omap
-          - MAM01237c: -1
-          - MAM01238c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01237c: 1
+          - MAM01238c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78816,13 +79018,13 @@
       - id: "MAR00249"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-          - MAM02938c: 1
-          - MAM02941c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+          - MAM02938c: -1
+          - MAM02941c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78841,7 +79043,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78854,13 +79056,13 @@
       - id: "MAR00259"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01585c: 1
-          - MAM01586c: -1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01585c: -1
+          - MAM01586c: 1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78892,13 +79094,13 @@
       - id: "MAR00267"
       - name: ""
       - metabolites: !!omap
-          - MAM00127c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01778c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00127c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01778c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78911,13 +79113,13 @@
       - id: "MAR00271"
       - name: ""
       - metabolites: !!omap
-          - MAM00020c: -1
-          - MAM00115c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00020c: 1
+          - MAM00115c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78936,7 +79138,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78949,13 +79151,13 @@
       - id: "MAR00279"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02612c: -1
-          - MAM02613c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02612c: 1
+          - MAM02613c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78968,13 +79170,13 @@
       - id: "MAR00283"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01771c: 1
-          - MAM01773c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01771c: -1
+          - MAM01773c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -78993,7 +79195,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79006,13 +79208,13 @@
       - id: "MAR00293"
       - name: ""
       - metabolites: !!omap
-          - MAM00007c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01584c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00007c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01584c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79031,7 +79233,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79044,13 +79246,13 @@
       - id: "MAR00301"
       - name: ""
       - metabolites: !!omap
-          - MAM00123c: -1
-          - MAM01207c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00123c: 1
+          - MAM01207c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79063,13 +79265,13 @@
       - id: "MAR00305"
       - name: ""
       - metabolites: !!omap
-          - MAM00101c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02457c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00101c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02457c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79082,13 +79284,13 @@
       - id: "MAR00309"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02052c: -1
-          - MAM02053c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02052c: 1
+          - MAM02053c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79101,13 +79303,13 @@
       - id: "MAR00313"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01373c: 1
-          - MAM01597c: 1
-          - MAM01725c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01373c: -1
+          - MAM01597c: -1
+          - MAM01725c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79120,13 +79322,13 @@
       - id: "MAR00319"
       - name: ""
       - metabolites: !!omap
-          - MAM00016c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01583c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00016c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01583c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79139,13 +79341,13 @@
       - id: "MAR00323"
       - name: ""
       - metabolites: !!omap
-          - MAM00006c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01582c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00006c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01582c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79158,13 +79360,13 @@
       - id: "MAR00327"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-          - MAM03045c: 1
-          - MAM03047c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+          - MAM03045c: -1
+          - MAM03047c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79177,13 +79379,13 @@
       - id: "MAR00331"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02385c: 1
-          - MAM02759c: -1
-          - MAM02971c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02385c: -1
+          - MAM02759c: 1
+          - MAM02971c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79196,13 +79398,13 @@
       - id: "MAR00337"
       - name: ""
       - metabolites: !!omap
-          - MAM00025c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02564c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00025c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02564c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79215,13 +79417,13 @@
       - id: "MAR00341"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01432c: 1
-          - MAM01597c: 1
-          - MAM02110c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01432c: -1
+          - MAM01597c: -1
+          - MAM02110c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79234,13 +79436,13 @@
       - id: "MAR00345"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02112c: -1
-          - MAM02759c: -1
-          - MAM03153c: 1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02112c: 1
+          - MAM02759c: 1
+          - MAM03153c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79253,13 +79455,13 @@
       - id: "MAR00349"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02389c: 1
-          - MAM02390c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02389c: -1
+          - MAM02390c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79272,13 +79474,13 @@
       - id: "MAR00353"
       - name: ""
       - metabolites: !!omap
-          - MAM00108c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-          - MAM02939c: 1
-      - lower_bound: -1000
+          - MAM00108c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+          - MAM02939c: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79291,13 +79493,13 @@
       - id: "MAR00357"
       - name: ""
       - metabolites: !!omap
-          - MAM00125c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02648c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00125c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02648c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79310,13 +79512,13 @@
       - id: "MAR00361"
       - name: ""
       - metabolites: !!omap
-          - MAM00103c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01784c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00103c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01784c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79329,13 +79531,13 @@
       - id: "MAR00365"
       - name: ""
       - metabolites: !!omap
-          - MAM00121c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01741c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00121c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01741c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79354,7 +79556,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79373,7 +79575,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79386,13 +79588,13 @@
       - id: "MAR00377"
       - name: ""
       - metabolites: !!omap
-          - MAM00095c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01689c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00095c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01689c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79411,7 +79613,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79430,7 +79632,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79449,7 +79651,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79468,7 +79670,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79481,13 +79683,13 @@
       - id: "MAR00397"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02387c: 1
-          - MAM02391c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02387c: -1
+          - MAM02391c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79500,13 +79702,13 @@
       - id: "MAR00401"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01932c: 1
-          - MAM01934c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01932c: -1
+          - MAM01934c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79519,13 +79721,13 @@
       - id: "MAR00405"
       - name: ""
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM01696c: 1
-          - MAM01697c: -1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM01696c: -1
+          - MAM01697c: 1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79538,13 +79740,13 @@
       - id: "MAR00409"
       - name: "Arachidonate:CoA ligase (AMP-forming)"
       - metabolites: !!omap
-          - MAM01334c: -1
-          - MAM01362c: 1
-          - MAM01364c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01334c: 1
+          - MAM01362c: -1
+          - MAM01364c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79557,13 +79759,13 @@
       - id: "MAR00413"
       - name: ""
       - metabolites: !!omap
-          - MAM00119c: -1
-          - MAM01291c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00119c: 1
+          - MAM01291c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79582,7 +79784,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79601,7 +79803,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79620,7 +79822,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79639,7 +79841,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79658,7 +79860,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79671,13 +79873,13 @@
       - id: "MAR00437"
       - name: ""
       - metabolites: !!omap
-          - MAM00264c: -1
-          - MAM00265c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00264c: 1
+          - MAM00265c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79690,13 +79892,13 @@
       - id: "MAR02942"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02344r: 1
-          - MAM02345r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02344r: -1
+          - MAM02345r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79709,13 +79911,13 @@
       - id: "MAR02943"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-          - MAM03050r: -1
-          - MAM03051r: 1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+          - MAM03050r: 1
+          - MAM03051r: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79728,13 +79930,13 @@
       - id: "MAR02944"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02494r: 1
-          - MAM02495r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02494r: -1
+          - MAM02495r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79747,13 +79949,13 @@
       - id: "MAR02945"
       - name: ""
       - metabolites: !!omap
-          - MAM01141r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02745r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01141r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02745r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79772,7 +79974,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79791,7 +79993,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79804,13 +80006,13 @@
       - id: "MAR02948"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02689r: -1
-          - MAM02690r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02689r: 1
+          - MAM02690r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79823,13 +80025,13 @@
       - id: "MAR02949"
       - name: "Palmitate:CoA ligase (AMP-forming)"
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02674r: 1
-          - MAM02678r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02674r: -1
+          - MAM02678r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79842,13 +80044,13 @@
       - id: "MAR02951"
       - name: ""
       - metabolites: !!omap
-          - MAM01191r: -1
-          - MAM01197r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01191r: 1
+          - MAM01197r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79861,13 +80063,13 @@
       - id: "MAR02952"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02675r: 1
-          - MAM02677r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02675r: -1
+          - MAM02677r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79880,13 +80082,13 @@
       - id: "MAR02954"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02101r: -1
-          - MAM02456r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02101r: 1
+          - MAM02456r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79905,7 +80107,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79918,13 +80120,13 @@
       - id: "MAR02956"
       - name: ""
       - metabolites: !!omap
-          - MAM01237r: -1
-          - MAM01238r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01237r: 1
+          - MAM01238r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79937,13 +80139,13 @@
       - id: "MAR02957"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-          - MAM02938r: 1
-          - MAM02941r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+          - MAM02938r: -1
+          - MAM02941r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -79975,13 +80177,13 @@
       - id: "MAR02961"
       - name: ""
       - metabolites: !!omap
-          - MAM00127r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01778r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00127r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01778r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80000,7 +80202,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80013,13 +80215,13 @@
       - id: "MAR02963"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01585r: 1
-          - MAM01586r: -1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01585r: -1
+          - MAM01586r: 1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80038,7 +80240,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80051,13 +80253,13 @@
       - id: "MAR02965"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02612r: -1
-          - MAM02613r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02612r: 1
+          - MAM02613r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80070,13 +80272,13 @@
       - id: "MAR02966"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01771r: 1
-          - MAM01773r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01771r: -1
+          - MAM01773r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80089,13 +80291,13 @@
       - id: "MAR02967"
       - name: ""
       - metabolites: !!omap
-          - MAM00007r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01584r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00007r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01584r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80114,7 +80316,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80133,7 +80335,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80146,13 +80348,13 @@
       - id: "MAR02970"
       - name: ""
       - metabolites: !!omap
-          - MAM00123r: -1
-          - MAM01207r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00123r: 1
+          - MAM01207r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80165,13 +80367,13 @@
       - id: "MAR02971"
       - name: ""
       - metabolites: !!omap
-          - MAM00101r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02457r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00101r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02457r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80184,13 +80386,13 @@
       - id: "MAR02972"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02052r: -1
-          - MAM02053r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02052r: 1
+          - MAM02053r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80203,13 +80405,13 @@
       - id: "MAR02973"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01373r: 1
-          - MAM01597r: 1
-          - MAM01725r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01373r: -1
+          - MAM01597r: -1
+          - MAM01725r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80222,13 +80424,13 @@
       - id: "MAR02974"
       - name: ""
       - metabolites: !!omap
-          - MAM00016r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01583r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00016r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01583r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80241,13 +80443,13 @@
       - id: "MAR02975"
       - name: ""
       - metabolites: !!omap
-          - MAM00006r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01582r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00006r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01582r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80260,13 +80462,13 @@
       - id: "MAR02976"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-          - MAM03045r: 1
-          - MAM03047r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+          - MAM03045r: -1
+          - MAM03047r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80279,13 +80481,13 @@
       - id: "MAR02977"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02385r: 1
-          - MAM02759r: -1
-          - MAM02971r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02385r: -1
+          - MAM02759r: 1
+          - MAM02971r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80298,13 +80500,13 @@
       - id: "MAR02978"
       - name: ""
       - metabolites: !!omap
-          - MAM00025r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02564r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00025r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02564r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80317,13 +80519,13 @@
       - id: "MAR02979"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01432r: 1
-          - MAM01597r: 1
-          - MAM02110r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01432r: -1
+          - MAM01597r: -1
+          - MAM02110r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80336,13 +80538,13 @@
       - id: "MAR02980"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02112r: -1
-          - MAM02759r: -1
-          - MAM03153r: 1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02112r: 1
+          - MAM02759r: 1
+          - MAM03153r: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80355,13 +80557,13 @@
       - id: "MAR02981"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02389r: 1
-          - MAM02390r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02389r: -1
+          - MAM02390r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80374,13 +80576,13 @@
       - id: "MAR02982"
       - name: ""
       - metabolites: !!omap
-          - MAM00108r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-          - MAM02939r: 1
-      - lower_bound: -1000
+          - MAM00108r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+          - MAM02939r: -1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80393,13 +80595,13 @@
       - id: "MAR02983"
       - name: ""
       - metabolites: !!omap
-          - MAM00125r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02648r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00125r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02648r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80412,13 +80614,13 @@
       - id: "MAR02984"
       - name: ""
       - metabolites: !!omap
-          - MAM00103r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01784r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00103r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01784r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80431,13 +80633,13 @@
       - id: "MAR02985"
       - name: ""
       - metabolites: !!omap
-          - MAM00121r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01741r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00121r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01741r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80456,7 +80658,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80475,7 +80677,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80488,13 +80690,13 @@
       - id: "MAR02988"
       - name: ""
       - metabolites: !!omap
-          - MAM00095r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01689r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00095r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01689r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80513,7 +80715,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80532,7 +80734,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80545,13 +80747,13 @@
       - id: "MAR02991"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02387r: 1
-          - MAM02391r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02387r: -1
+          - MAM02391r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80564,13 +80766,13 @@
       - id: "MAR02992"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01932r: 1
-          - MAM01934r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01932r: -1
+          - MAM01934r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80583,13 +80785,13 @@
       - id: "MAR02994"
       - name: ""
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM01696r: 1
-          - MAM01697r: -1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM01696r: -1
+          - MAM01697r: 1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80602,13 +80804,13 @@
       - id: "MAR02996"
       - name: "Arachidonate:CoA ligase (AMP-forming)"
       - metabolites: !!omap
-          - MAM01334r: -1
-          - MAM01362r: 1
-          - MAM01364r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01334r: 1
+          - MAM01362r: -1
+          - MAM01364r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80621,13 +80823,13 @@
       - id: "MAR02998"
       - name: ""
       - metabolites: !!omap
-          - MAM00119r: -1
-          - MAM01291r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00119r: 1
+          - MAM01291r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80646,7 +80848,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80665,7 +80867,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80684,7 +80886,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80703,7 +80905,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -80722,7 +80924,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88086,13 +88288,13 @@
       - id: "MAR01157"
       - name: ""
       - metabolites: !!omap
-          - MAM01120c: -1
-          - MAM01152c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01120c: 1
+          - MAM01152c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88105,13 +88307,13 @@
       - id: "MAR01158"
       - name: ""
       - metabolites: !!omap
-          - MAM01120m: -1
-          - MAM01152m: 1
-          - MAM01334m: -1
-          - MAM01371m: 1
-          - MAM01597m: 1
-          - MAM02759m: -1
-      - lower_bound: -1000
+          - MAM01120m: 1
+          - MAM01152m: -1
+          - MAM01334m: 1
+          - MAM01371m: -1
+          - MAM01597m: -1
+          - MAM02759m: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88124,13 +88326,13 @@
       - id: "MAR01159"
       - name: ""
       - metabolites: !!omap
-          - MAM01120r: -1
-          - MAM01152r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01120r: 1
+          - MAM01152r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88143,13 +88345,13 @@
       - id: "MAR01160"
       - name: ""
       - metabolites: !!omap
-          - MAM01120x: -1
-          - MAM01152x: 1
-          - MAM01334x: -1
-          - MAM01371x: 1
-          - MAM01597x: 1
-          - MAM02759x: -1
-      - lower_bound: -1000
+          - MAM01120x: 1
+          - MAM01152x: -1
+          - MAM01334x: 1
+          - MAM01371x: -1
+          - MAM01597x: -1
+          - MAM02759x: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88493,13 +88695,13 @@
       - id: "MAR01200"
       - name: ""
       - metabolites: !!omap
-          - MAM01122c: -1
-          - MAM01151c: 1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM01122c: 1
+          - MAM01151c: -1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88512,13 +88714,13 @@
       - id: "MAR01201"
       - name: ""
       - metabolites: !!omap
-          - MAM01122m: -1
-          - MAM01151m: 1
-          - MAM01334m: -1
-          - MAM01371m: 1
-          - MAM01597m: 1
-          - MAM02759m: -1
-      - lower_bound: -1000
+          - MAM01122m: 1
+          - MAM01151m: -1
+          - MAM01334m: 1
+          - MAM01371m: -1
+          - MAM01597m: -1
+          - MAM02759m: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88531,13 +88733,13 @@
       - id: "MAR01202"
       - name: ""
       - metabolites: !!omap
-          - MAM01122r: -1
-          - MAM01151r: 1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM01122r: 1
+          - MAM01151r: -1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88550,13 +88752,13 @@
       - id: "MAR01203"
       - name: ""
       - metabolites: !!omap
-          - MAM01122x: -1
-          - MAM01151x: 1
-          - MAM01334x: -1
-          - MAM01371x: 1
-          - MAM01597x: 1
-          - MAM02759x: -1
-      - lower_bound: -1000
+          - MAM01122x: 1
+          - MAM01151x: -1
+          - MAM01334x: 1
+          - MAM01371x: -1
+          - MAM01597x: -1
+          - MAM02759x: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88913,7 +89115,7 @@
           - MAM01371c: -1
           - MAM01597c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88932,7 +89134,7 @@
           - MAM01371m: -1
           - MAM01597m: -1
           - MAM02759m: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88951,7 +89153,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -88970,7 +89172,7 @@
           - MAM01371x: -1
           - MAM01597x: -1
           - MAM02759x: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -89119,13 +89321,13 @@
       - id: "MAR01263"
       - name: ""
       - metabolites: !!omap
-          - MAM00257c: 1
-          - MAM00258c: -1
-          - MAM01334c: -1
-          - MAM01371c: 1
-          - MAM01597c: 1
-          - MAM02759c: -1
-      - lower_bound: -1000
+          - MAM00257c: -1
+          - MAM00258c: 1
+          - MAM01334c: 1
+          - MAM01371c: -1
+          - MAM01597c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -89138,13 +89340,13 @@
       - id: "MAR01264"
       - name: ""
       - metabolites: !!omap
-          - MAM00257m: 1
-          - MAM00258m: -1
-          - MAM01334m: -1
-          - MAM01371m: 1
-          - MAM01597m: 1
-          - MAM02759m: -1
-      - lower_bound: -1000
+          - MAM00257m: -1
+          - MAM00258m: 1
+          - MAM01334m: 1
+          - MAM01371m: -1
+          - MAM01597m: -1
+          - MAM02759m: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -89157,13 +89359,13 @@
       - id: "MAR01265"
       - name: ""
       - metabolites: !!omap
-          - MAM00257r: 1
-          - MAM00258r: -1
-          - MAM01334r: -1
-          - MAM01371r: 1
-          - MAM01597r: 1
-          - MAM02759r: -1
-      - lower_bound: -1000
+          - MAM00257r: -1
+          - MAM00258r: 1
+          - MAM01334r: 1
+          - MAM01371r: -1
+          - MAM01597r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -89176,13 +89378,13 @@
       - id: "MAR01266"
       - name: ""
       - metabolites: !!omap
-          - MAM00257x: 1
-          - MAM00258x: -1
-          - MAM01334x: -1
-          - MAM01371x: 1
-          - MAM01597x: 1
-          - MAM02759x: -1
-      - lower_bound: -1000
+          - MAM00257x: -1
+          - MAM00258x: 1
+          - MAM01334x: 1
+          - MAM01371x: -1
+          - MAM01597x: -1
+          - MAM02759x: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -89457,13 +89659,13 @@
       - id: "MAR01290"
       - name: ""
       - metabolites: !!omap
-          - MAM00586x: 1
-          - MAM00587x: -1
-          - MAM01334x: -1
-          - MAM01371x: 1
-          - MAM01597x: 1
-          - MAM02759x: -1
-      - lower_bound: -1000
+          - MAM00586x: -1
+          - MAM00587x: 1
+          - MAM01334x: 1
+          - MAM01371x: -1
+          - MAM01597x: -1
+          - MAM02759x: 1
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -121952,7 +122154,7 @@
           - MAM02586c: -1
           - MAM02759c: 1
           - MAM02806c: -1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Naprt"
       - rxnNotes: ""
@@ -121970,7 +122172,7 @@
           - MAM02039c: -1
           - MAM02585c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Nmnat"
       - rxnNotes: ""
@@ -122153,7 +122355,7 @@
           - MAM02039n: -1
           - MAM02585n: -1
           - MAM02759n: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Nmnat"
       - rxnNotes: ""
@@ -126690,7 +126892,7 @@
           - MAM02553c: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "CG10657 or CG8888 or CG9265 or Cralbp or Dhrs4"
+      - gene_reaction_rule: "CG10657 or CG8888 or CG9265 or Cralbp or Dhrs4 or Fdh"
       - rxnNotes: ""
       - eccodes: "1.1.1.105"
       - references: ""
@@ -131433,9 +131635,9 @@
           - MAM02039c: 1
           - MAM02040c: -1
           - MAM02046c: 1
-      - lower_bound: 0
+      - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "APP-BP1 or CAH1 or CAH16 or CAH2 or CAH4 or CAH5 or CAH6 or CAH7 or CAH9"
+      - gene_reaction_rule: "CAH1"
       - rxnNotes: ""
       - eccodes: "4.2.1.1"
       - references: ""
@@ -131543,38 +131745,6 @@
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05406"
-      - name: "carbonate hydro-lyase (carbon-dioxide-forming)"
-      - metabolites: !!omap
-          - MAM01421c: 1
-          - MAM01596c: -1
-          - MAM02040c: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "APP-BP1 or CAH1 or CAH16 or CAH2 or CAH4 or CAH5 or CAH6 or CAH7 or CAH9"
-      - rxnNotes: ""
-      - eccodes: "4.2.1.1"
-      - references: "PMID:10938543;PMID:11493685;PMID:12713833;PMID:12747791;PMID:14640555;PMID:17259996;PMID:17504134;PMID:17826101;PMID:7011879;PMID:7672338"
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR05409"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01421e: -1
-          - MAM02039e: 1
-          - MAM02046e: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
     - !!omap
       - id: "MAR07794"
       - name: "diphosphate phosphohydrolase"
@@ -131610,54 +131780,6 @@
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR08749"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01421c: 1
-          - MAM02039c: -1
-          - MAM02046c: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR08750"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01421m: 1
-          - MAM02039m: -1
-          - MAM02046m: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR08751"
-      - name: "carbonate hydro-lyase (carbon-dioxide-forming)"
-      - metabolites: !!omap
-          - MAM01421m: 1
-          - MAM01596m: -1
-          - MAM02040m: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "CAH1"
-      - rxnNotes: ""
-      - eccodes: "4.2.1.1"
-      - references: ""
-      - subsystem:
-          - "Miscellaneous"
-      - confidence_score: 0
     - !!omap
       - id: "MAR08752"
       - name: ""
@@ -137726,7 +137848,7 @@
           - MAM02751e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG15096 or CG2003 or CG3649 or CG7881 or CG9825 or CG9864 or MFS12 or dmGlut"
+      - gene_reaction_rule: "CG15096 or CG2003 or CG3649 or CG7881 or CG9825 or CG9864 or MFS12 or NaPi-III or dmGlut"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12750889;PMID:12759754;PMID:12806205;PMID:12811560"
@@ -139118,28 +139240,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05295"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01285c: 1
-          - MAM01371c: -1
-          - MAM02039c: 1
-          - MAM02040c: -1
-          - MAM02200c: 1
-          - MAM02200e: -1
-          - MAM02519c: -1
-          - MAM02519e: 1
-          - MAM02751c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "((nrv1 or nrv2 or nrv3) and Atpα)"
-      - rxnNotes: ""
-      - eccodes: "3.6.3.9"
-      - references: "PMID:2835623;PMID:6258180"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR05296"
       - name: ""
@@ -139180,7 +139280,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or CG5535 or Eaat1 or GlyT or slif"
+      - gene_reaction_rule: "CG43066 or CG5535 or Eaat1 or slif"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -139197,7 +139297,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or Eaat1 or GlyT"
+      - gene_reaction_rule: "CG43066 or Eaat1"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -139214,7 +139314,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -139231,7 +139331,7 @@
           - MAM03135e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12930836;PMID:17322374"
@@ -139248,7 +139348,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CD98hc or CG43066 or CG5535 or GlyT or slif"
+      - gene_reaction_rule: "CD98hc or CG43066 or CG5535 or slif"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12930836;PMID:17322374"
@@ -139265,7 +139365,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12930836;PMID:17322374"
@@ -139282,7 +139382,7 @@
           - MAM03089e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -139299,7 +139399,7 @@
           - MAM03101e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -139316,7 +139416,7 @@
           - MAM02724e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or CG5535 or GlyT or slif"
+      - gene_reaction_rule: "CG43066 or CG5535 or slif"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -139333,7 +139433,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -139367,7 +139467,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or CG6126 or GlyT"
+      - gene_reaction_rule: "CG43066 or CG6126"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534"
@@ -139384,7 +139484,7 @@
           - MAM02993e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -139445,40 +139545,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05333"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02125c: 1
-          - MAM02125e: -1
-          - MAM02519c: 1
-          - MAM02519e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:10823827;PMID:12845534"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR05413"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02039c: 1
-          - MAM02039e: -1
-          - MAM02751c: 1
-          - MAM02751e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "NaPi-III"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR05429"
       - name: ""
@@ -139497,7 +139563,7 @@
       - gene_reaction_rule: "((nrv1 or nrv2 or nrv3) and Atpα)"
       - rxnNotes: "DOI:10.1002/9780470691861"
       - eccodes: ""
-      - references: ""
+      - references: "PMID:2835623;PMID:6258180"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -154988,7 +155054,7 @@
           - MAM02896e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or GlyT"
+      - gene_reaction_rule: "CG43066"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -155005,7 +155071,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG43066 or Eaat1 or GlyT"
+      - gene_reaction_rule: "CG43066 or Eaat1"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:12845534;PMID:10823827;PMID:11452978;PMID:15632147"
@@ -155029,63 +155095,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR06380"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01975c: 1
-          - MAM01975e: -1
-          - MAM02039c: -1
-          - MAM02039e: 1
-          - MAM02519c: 1
-          - MAM02519e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12845534"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR06381"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02039c: -1
-          - MAM02039e: 1
-          - MAM02519c: 1
-          - MAM02519e: -1
-          - MAM02896c: 1
-          - MAM02896e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12845534"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR06382"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01369c: 1
-          - MAM01369e: -1
-          - MAM02039c: -1
-          - MAM02039e: 1
-          - MAM02519c: 1
-          - MAM02519e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12845534"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06383"
       - name: ""
@@ -155105,25 +155114,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR06384"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02039c: -1
-          - MAM02039e: 1
-          - MAM02125c: 1
-          - MAM02125e: -1
-          - MAM02519c: 1
-          - MAM02519e: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12845534"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06392"
       - name: ""
@@ -158317,7 +158307,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "GlyT"
+      - gene_reaction_rule: ""
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -159308,7 +159298,7 @@
           - MAM02519e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "CG6126 or GlyT"
+      - gene_reaction_rule: "CG6126"
       - rxnNotes: ""
       - eccodes: ""
       - references: ""
@@ -173380,21 +173370,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00464"
-      - name: ""
-      - metabolites: !!omap
-          - MAM02685c: -1
-          - MAM02685r: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00466"
       - name: ""
@@ -182168,10 +182143,9 @@
           - MAM03161c: -1
           - MAM03970c: 1
       - lower_bound: 0
-      - upper_bound: 1000
+      - upper_bound: 0
       - gene_reaction_rule: ""
       - rxnNotes: ""
-      - objective_coefficient: 1
       - eccodes: ""
       - references: ""
       - subsystem:
@@ -184779,40 +184753,6 @@
       - subsystem:
           - "N-glycan metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00562"
-      - name: "Electron Transfer Flavoprotein"
-      - metabolites: !!omap
-          - MAM01802m: 1
-          - MAM01803m: -1
-          - MAM03573m: -1
-          - MAM03574m: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Etfb and wal"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:3170610;PMID:7601336"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR00563"
-      - name: "Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase"
-      - metabolites: !!omap
-          - MAM03102m: 1
-          - MAM03103m: -1
-          - MAM03573m: 1
-          - MAM03574m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Etf-QO"
-      - rxnNotes: ""
-      - eccodes: "1.5.5.1"
-      - references: "PMID:10444348;PMID:12049629"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00564"
       - name: "Exchange of 1 Acyl Phosphoglycerol"
@@ -185657,7 +185597,7 @@
           - MAM01597c: -1
           - MAM01778c: -1
           - MAM02759c: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "CG3961"
       - rxnNotes: ""
@@ -187457,10 +187397,13 @@
       - metabolites: !!omap
           - MAM01285c: 1
           - MAM01371c: -1
-          - MAM02039e: 1
+          - MAM02039c: 1
+          - MAM02039e: -1
           - MAM02040c: -1
           - MAM02200c: 1
           - MAM02200e: -1
+          - MAM02519c: -2
+          - MAM02519e: 2
           - MAM02751c: 1
       - lower_bound: 0
       - upper_bound: 1000
@@ -190414,7 +190357,7 @@
           - MAM02039e: 1
           - MAM02040e: -1
           - MAM02759e: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "CG8891"
       - rxnNotes: ""
@@ -191620,7 +191563,7 @@
           - MAM02751e: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG10483 or CG7536"
       - rxnNotes: ""
       - eccodes: "4.2.1.1"
       - references: "PMID:10938543;PMID:11493685;PMID:12713833;PMID:12747791;PMID:14640555;PMID:17259996;PMID:17504134;PMID:17826101;PMID:7011879;PMID:7672338"
@@ -192409,24 +192352,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02490"
-      - name: "Ribonucleoside-Diphosphate Reductase"
-      - metabolites: !!omap
-          - MAM01756m: 1
-          - MAM02040m: 1
-          - MAM02666m: 1
-          - MAM02990m: -1
-          - MAM03130m: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: "1.17.4.1"
-      - references: "PMID:6997299;PMID:8483833"
-      - subsystem:
-          - "Pyrimidine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR02492"
       - name: "3-Hydroxyacyl Coenzyme A Dehydrogenase"
@@ -195105,7 +195030,7 @@
           - MAM01597x: -1
           - MAM02759x: 1
           - MAM02766x: -1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961 or bgm"
       - rxnNotes: ""
@@ -196681,7 +196606,7 @@
           - MAM01371m: -1
           - MAM01597m: -1
           - MAM02759m: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -196700,7 +196625,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -196719,7 +196644,7 @@
           - MAM01371x: -1
           - MAM01597x: -1
           - MAM02759x: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -196951,7 +196876,7 @@
           - MAM01371m: -1
           - MAM01597m: -1
           - MAM02759m: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -196970,7 +196895,7 @@
           - MAM01371r: -1
           - MAM01597r: -1
           - MAM02759r: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -196989,7 +196914,7 @@
           - MAM01371x: -1
           - MAM01597x: -1
           - MAM02759x: 1
-      - lower_bound: -1000
+      - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "Acsl or CG3961"
       - rxnNotes: ""
@@ -199211,23 +199136,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04411"
-      - name: "Phosphate Transport In/Out via Na+ Symporter"
-      - metabolites: !!omap
-          - MAM02519c: 1.5
-          - MAM02519e: -1.5
-          - MAM02751c: 1
-          - MAM02751e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "NaPi-III"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12759754"
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04413"
       - name: "Generic Human Biomass Reaction"
@@ -199549,23 +199457,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04562"
-      - name: "Production of Myristoylcarnitine"
-      - metabolites: !!omap
-          - MAM01597c: 1
-          - MAM02348c: -1
-          - MAM02495c: -1
-          - MAM02973c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "whd"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:19137688;PMID:15653102;PMID:12403251"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR04566"
       - name: "Transport of 3-Hydroxytetradecenoyl Coenzyme A from Mitochondria into Cytosol"
@@ -200468,7 +200359,7 @@
       - id: "MAR04886"
       - name: "Exchange of Malonyl Carnitine"
       - metabolites: !!omap
-          - MAM03494e: -1
+          - MAM02443e: -1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -202874,23 +202765,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR05434"
-      - name: "Malonylcoa->Malonylcarnitine"
-      - metabolites: !!omap
-          - MAM01597c: 1
-          - MAM02348c: -1
-          - MAM02444c: -1
-          - MAM03494c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "whd"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:12651823;PMID:18192268"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR05449"
       - name: "Fatty Acid Beta Oxidation (C4->C2), Mitochondrial"
@@ -202980,7 +202854,7 @@
           - MAM03242m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG8778"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:8582058"
@@ -206201,23 +206075,6 @@
       - subsystem:
           - "Pantothenate and CoA metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR08985"
-      - name: "6-Phosphogluconolactonase"
-      - metabolites: !!omap
-          - MAM01169c: 3
-          - MAM01961c: -3
-          - MAM02039c: 3
-          - MAM02040c: -3
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Pgls"
-      - rxnNotes: "Harpers illustrated Biochemistry (2009) 28th edition pages 174-183, ISBN:9781282335806"
-      - eccodes: "3.1.1.31"
-      - references: "PMID:4382012;PMID:13575411"
-      - subsystem:
-          - "Pentose phosphate pathway"
-      - confidence_score: 0
     - !!omap
       - id: "MAR08986"
       - name: "(R)-Pantetheine Amidohydrolase"
@@ -206295,21 +206152,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR08992"
-      - name: "Ribulose 5-Phosphate 3-Epimerase"
-      - metabolites: !!omap
-          - MAM01761c: 2
-          - MAM02846c: -2
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: "Rpe"
-      - rxnNotes: "Harpers illustrated Biochemistry (2009) 28th edition pages 174-183, ISBN:9781282335806"
-      - eccodes: "5.1.3.1"
-      - references: "PMID:4382012;PMID:13575411"
-      - subsystem:
-          - "Pentose phosphate pathway"
-      - confidence_score: 0
     - !!omap
       - id: "MAR08993"
       - name: "Formation of Sulfocysteine"
@@ -209566,10 +209408,10 @@
           - MAM02039e: 2
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG2930 or yin"
       - rxnNotes: ""
       - eccodes: "3.1.1.4"
-      - references: "PMID:11752223"
+      - references: "PMID:19789362"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -214357,21 +214199,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR10410"
-      - name: "Transport of W-Hydroxyl Arachidonic Acid, Diffusion"
-      - metabolites: !!omap
-          - MAM00270c: -1
-          - MAM00270e: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Transport reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR10411"
       - name: "Transport of W-Hydroxyl Arachidonic Acid, Intracellular"
@@ -227950,8 +227777,8 @@
       - id: "MAR11256"
       - name: "Transport of Malonyl Carnitine"
       - metabolites: !!omap
-          - MAM03494c: 1
-          - MAM03494e: -1
+          - MAM02443c: 1
+          - MAM02443e: -1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -228680,10 +228507,10 @@
           - MAM02039e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG13384 or CG2930 or CG43693 or yin"
       - rxnNotes: ""
       - eccodes: ""
-      - references: "PMID:21749716"
+      - references: "PMID:19789362"
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
@@ -228722,23 +228549,6 @@
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR11310"
-      - name: "Carnitine Octadecenoyl Transferase"
-      - metabolites: !!omap
-          - MAM01597c: -1
-          - MAM02348c: 1
-          - MAM02639c: -1
-          - MAM02647c: 1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: "PMID:21749716"
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR11311"
       - name: "Calcium (Ca+2) Transport via Diffusion (Extracellular to Cytosol)"
@@ -230475,10 +230285,10 @@
           - MAM02819c: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG5793"
       - rxnNotes: ""
       - eccodes: ""
-      - references: ""
+      - references: "PMID:25575590"
       - subsystem:
           - "Miscellaneous"
       - confidence_score: 0
@@ -231780,7 +231590,7 @@
           - MAM03964m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: ""
+      - gene_reaction_rule: "CG8778"
       - rxnNotes: "https://www.springer.com/gp/book/9789400957800"
       - eccodes: ""
       - references: "PMID:16573641;PMID:18348873;PMID:16111821"
@@ -236386,7 +236196,7 @@
           - MAM02891e: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "(Ance-3 and CG43066) or CG43066 or CG6126 or GlyT"
+      - gene_reaction_rule: "(Ance-3 and CG43066) or CG43066 or CG6126"
       - rxnNotes: ""
       - eccodes: ""
       - references: "PMID:2723818"
@@ -256313,20 +256123,6 @@
       - subsystem:
           - "Exchange/demand reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR13066"
-      - name: "EX_h2co3[e]"
-      - metabolites: !!omap
-          - MAM01421e: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Exchange/demand reactions"
-      - confidence_score: 0
     - !!omap
       - id: "MAR13067"
       - name: "EX_M02837[e]"
@@ -257702,9 +257498,10 @@
           - MAM10014c: -0.2212
           - MAM10015c: -0.4835
       - lower_bound: 0
-      - upper_bound: 0
+      - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: ""
+      - objective_coefficient: 1
       - eccodes: ""
       - references: ""
       - subsystem:
@@ -258916,24 +258713,6 @@
       - subsystem:
           - "Retinol metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20004"
-      - name: "MAR20004"
-      - metabolites: !!omap
-          - MAM01230c: 1
-          - MAM01232c: -1
-          - MAM02039c: 1
-          - MAM02552c: -1
-          - MAM02553c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Fdh"
-      - rxnNotes: ""
-      - eccodes: "1.1.1.315"
-      - references: ""
-      - subsystem:
-          - "Retinol metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20005"
       - name: "MAR20005"
@@ -259327,24 +259106,6 @@
       - subsystem:
           - "Isolated"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20045"
-      - name: "MAR20045"
-      - metabolites: !!omap
-          - MAM01837c: 1
-          - MAM02039c: 1
-          - MAM02152c: -1
-          - MAM02552c: -1
-          - MAM02553c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Fdh"
-      - rxnNotes: ""
-      - eccodes: "1.1.1.284"
-      - references: ""
-      - subsystem:
-          - "Isolated"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20046"
       - name: "MAR20046"
@@ -259459,25 +259220,6 @@
       - subsystem:
           - "Fatty acid metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR20052"
-      - name: "MAR20052"
-      - metabolites: !!omap
-          - MAM00564c: -1
-          - MAM02039c: 2
-          - MAM02040c: -1
-          - MAM02552c: -1
-          - MAM02553c: 1
-          - MAM02766c: 1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "Aldh-III"
-      - rxnNotes: ""
-      - eccodes: ""
-      - references: ""
-      - subsystem:
-          - "Fatty acid metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR20053"
       - name: "MAR20053"
@@ -259775,6 +259517,315 @@
       - subsystem:
           - "Pentose Phosphate Pathway"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20071"
+      - name: "MAR20071"
+      - metabolites: !!omap
+          - MAM01127c: 1
+          - MAM02426c: 1
+          - MAM20061c: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Tina-1"
+      - rxnNotes: ""
+      - eccodes: "4.3.2.8"
+      - references: ""
+      - subsystem:
+          - "Alanine, aspartate and glutamate metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20072"
+      - name: "MAR20072"
+      - metabolites: !!omap
+          - MAM01127n: 1
+          - MAM02426n: 1
+          - MAM20061n: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Tina-1"
+      - rxnNotes: ""
+      - eccodes: "4.3.2.8"
+      - references: ""
+      - subsystem:
+          - "Alanine, aspartate and glutamate metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20089"
+      - name: "MAR20089"
+      - metabolites: !!omap
+          - MAM01107c: -1
+          - MAM01596c: 1
+          - MAM02039c: -1
+          - MAM02897c: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Ddc"
+      - rxnNotes: ""
+      - eccodes: "4.1.1.28"
+      - references: ""
+      - subsystem:
+          - "Tryptophan metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20090"
+      - name: "MAR20090"
+      - metabolites: !!omap
+          - MAM01806m: -1
+          - MAM02040m: -1
+          - MAM02049m: -1
+          - MAM02759m: 1
+          - MAM20064m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Cox10"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.-;2.5.1.141"
+      - references: ""
+      - subsystem:
+          - "Porphyrin metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20091"
+      - name: "MAR20091"
+      - metabolites: !!omap
+          - MAM01806c: -1
+          - MAM02040c: -1
+          - MAM02049c: -1
+          - MAM02759c: 1
+          - MAM20064c: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Cox10"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.-;2.5.1.141"
+      - references: ""
+      - subsystem:
+          - "Porphyrin metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20092"
+      - name: "MAR20092"
+      - metabolites: !!omap
+          - MAM01806n: -1
+          - MAM02040n: -1
+          - MAM02049n: -1
+          - MAM02759n: 1
+          - MAM20064n: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Cox10"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.-;2.5.1.141"
+      - references: ""
+      - subsystem:
+          - "Porphyrin metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20098"
+      - name: "MAR20098"
+      - metabolites: !!omap
+          - MAM01657r: 1
+          - MAM01806r: -1
+          - MAM02187r: -5
+          - MAM02759r: 5
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "Dhdds"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.87"
+      - references: ""
+      - subsystem:
+          - "Terpenoid backbone biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20099"
+      - name: "MAR20099"
+      - metabolites: !!omap
+          - MAM01252n: 1
+          - MAM01288n: 1
+          - MAM02039n: 1
+          - MAM02040n: -1
+          - MAM20077n: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "CG33054"
+      - rxnNotes: ""
+      - eccodes: "3.1.1.106"
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20100"
+      - name: "MAR20100"
+      - metabolites: !!omap
+          - MAM01288n: 1
+          - MAM02039n: 1
+          - MAM02040n: -1
+          - MAM02583n: 1
+          - MAM20063n: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "CG33054"
+      - rxnNotes: ""
+      - eccodes: ""
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20102"
+      - name: "MAR20102"
+      - metabolites: !!omap
+          - MAM02759c: 1
+          - MAM03590c: -1
+          - MAM20065c: -1
+          - MAM20066c: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.M22"
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20103"
+      - name: "MAR20103"
+      - metabolites: !!omap
+          - MAM02759r: 1
+          - MAM03590r: -1
+          - MAM20065r: -1
+          - MAM20066r: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.M22"
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20104"
+      - name: "MAR20104"
+      - metabolites: !!omap
+          - MAM02759g: 1
+          - MAM03590g: -1
+          - MAM20065g: -1
+          - MAM20066g: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.M22"
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20105"
+      - name: "MAR20105"
+      - metabolites: !!omap
+          - MAM02759n: 1
+          - MAM03590n: -1
+          - MAM20065n: -1
+          - MAM20066n: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.M22"
+      - references: ""
+      - subsystem:
+          - "Isolated"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20106"
+      - name: "MAR20106"
+      - metabolites: !!omap
+          - MAM00767c: 1
+          - MAM00995c: -1
+          - MAM01316c: -1
+          - MAM02759c: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.39"
+      - references: ""
+      - subsystem:
+          - "Ubiquinone and other terpenoid-quinone biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20107"
+      - name: "MAR20107"
+      - metabolites: !!omap
+          - MAM00767r: 1
+          - MAM00995r: -1
+          - MAM01316r: -1
+          - MAM02759r: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.39"
+      - references: ""
+      - subsystem:
+          - "Ubiquinone and other terpenoid-quinone biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20108"
+      - name: "MAR20108"
+      - metabolites: !!omap
+          - MAM00767g: 1
+          - MAM00995g: -1
+          - MAM01316g: -1
+          - MAM02759g: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.39"
+      - references: ""
+      - subsystem:
+          - "Ubiquinone and other terpenoid-quinone biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20109"
+      - name: "MAR20109"
+      - metabolites: !!omap
+          - MAM00767n: 1
+          - MAM00995n: -1
+          - MAM01316n: -1
+          - MAM02759n: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "heix"
+      - rxnNotes: ""
+      - eccodes: "2.5.1.39"
+      - references: ""
+      - subsystem:
+          - "Ubiquinone and other terpenoid-quinone biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20110"
+      - name: "MAR20110"
+      - metabolites: !!omap
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02633m: -1
+          - MAM02819m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "CG5793"
+      - rxnNotes: ""
+      - eccodes: ""
+      - references: "PMID:25575590"
+      - subsystem:
+          - "Miscellaneous"
+      - confidence_score: 0
     - !!omap
       - id: "MAR15001"
       - name: ""
@@ -260319,41 +260370,53 @@
           - "Glutathione metabolism"
       - confidence_score: 2
     - !!omap
-      - id: "MAR00114"
+      - id: "MAR00113"
       - name: "C-3 Sterol Dehydrogenase (4-Methylzymosterol)"
       - metabolites: !!omap
           - MAM00809r: 1
           - MAM00953r: -1
           - MAM01596r: 1
           - MAM02039r: 1
-          - MAM02552r: -1
-          - MAM02553r: 1
+          - MAM02554r: -1
+          - MAM02555r: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
       - eccodes: ""
-      - references: "PMID:12829805"
+      - references: "PMID:10710235;PMID:14506130"
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR00118"
-      - name: "C-4 Methyl Sterol Oxidase"
+      - id: "MAR00222"
+      - name: "24-Dehydrocholesterol Reductase [Precursor]"
       - metabolites: !!omap
-          - MAM00809r: -1
-          - MAM01596r: 1
-          - MAM02039r: 1
-          - MAM02552r: -1
-          - MAM02553r: 1
-          - MAM02630r: -1
-          - MAM04082r: 1
+          - MAM01450r: 1
+          - MAM01675r: -1
+          - MAM01802r: 1
+          - MAM01803r: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: ""
-      - references: ""
+      - eccodes: "2.3.1.42"
+      - references: "PMID:17984220;PMID:19520779;PMID:19520780"
+      - subsystem:
+          - "Cholesterol metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR00443"
+      - name: "3-Beta-Hydroxysteroid-Delta (8), Delta (7)-Isomerase"
+      - metabolites: !!omap
+          - MAM01066r: 1
+          - MAM03158r: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "5.3.3.5"
+      - references: "PMID:10391219"
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
@@ -260373,16 +260436,16 @@
           - "Cholesterol metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR01510"
+      - id: "MAR01508"
       - name: "Lathosterol Oxidase"
       - metabolites: !!omap
+          - MAM01066r: -1
+          - MAM01189r: 1
           - MAM02039r: -1
           - MAM02040r: 2
-          - MAM02343r: -1
           - MAM02554r: 1
           - MAM02555r: -1
           - MAM02630r: -1
-          - MAM02805r: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -260453,35 +260516,20 @@
           - "Cholesterol metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR02337"
-      - name: "Delta24-Sterol Reductase"
+      - id: "MAR02301"
+      - name: "Hydroxysteroid (17-Beta) Dehydrogenase 7"
       - metabolites: !!omap
-          - MAM01449r: 1
-          - MAM02039r: -1
-          - MAM02554r: 1
-          - MAM02555r: -1
-          - MAM03158r: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: "reaction added by gap filling"
-      - eccodes: "1.3.1.72"
-      - references: "PMID:12162789;PMID:9291139;PMID:9638657"
-      - subsystem:
-          - "Cholesterol metabolism"
-      - confidence_score: 0
-    - !!omap
-      - id: "MAR02339"
-      - name: "5Alpha-Cholest-7-En-3Beta-Ol Delta7-Delta8-Isomerase"
-      - metabolites: !!omap
-          - MAM01449r: 1
-          - MAM02343r: -1
+          - MAM00809r: -1
+          - MAM00968r: 1
+          - MAM02039r: -3
+          - MAM02554r: -1
+          - MAM02555r: 1
       - lower_bound: -1000
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: "5.3.3.5"
-      - references: "PMID:10391219;PMID:12133002;PMID:4475632;PMID:5810070"
+      - eccodes: "1.1.1.270"
+      - references: "PMID:10544267;PMID:12732193;PMID:12829805"
       - subsystem:
           - "Cholesterol metabolism"
       - confidence_score: 0
@@ -260545,19 +260593,20 @@
           - "Protein assembly"
       - confidence_score: 0
     - !!omap
-      - id: "MAR04106"
-      - name: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)"
+      - id: "MAR04497"
+      - name: "3-hydroxypropanoate:NAD+ oxidoreductase"
       - metabolites: !!omap
-          - MAM01261m: 1
-          - MAM01596m: 1
-          - MAM02039m: -1
-          - MAM02444m: -1
+          - MAM00900m: 1
+          - MAM02039m: 1
+          - MAM02142m: -1
+          - MAM02552m: -1
+          - MAM02553m: 1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
       - rxnNotes: "reaction added by gap filling"
-      - eccodes: "4.1.1.9"
-      - references: "PMID:101148;PMID:10455107;PMID:15003260;PMID:4180063;PMID:4731972;PMID:5578610;PMID:9869665"
+      - eccodes: "1.1.1.59"
+      - references: "PMID:13672942"
       - subsystem:
           - "Propanoate metabolism"
       - confidence_score: 0
@@ -260576,23 +260625,6 @@
       - subsystem:
           - "Transport reactions"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR04485"
-      - name: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase"
-      - metabolites: !!omap
-          - MAM00639c: -1
-          - MAM02751c: 1
-          - MAM02996c: 1
-          - MAM02997c: -1
-      - lower_bound: -1000
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: "reaction added by gap filling"
-      - eccodes: "2.4.2.1;2.4.2.4"
-      - references: "PMID:15262124;PMID:15990964"
-      - subsystem:
-          - "Pyrimidine metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06981"
       - name: "4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase"
@@ -260652,26 +260684,6 @@
       - subsystem:
           - "Omega-3 fatty acid metabolism"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR02380"
-      - name: ""
-      - metabolites: !!omap
-          - MAM01364c: 1
-          - MAM01697c: -1
-          - MAM02039c: -1
-          - MAM02040c: 2
-          - MAM02554c: 1
-          - MAM02555c: -1
-          - MAM02630c: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: ""
-      - rxnNotes: "reaction added by gap filling"
-      - eccodes: "1.14.19.-"
-      - references: ""
-      - subsystem:
-          - "Omega-6 fatty acid metabolism"
-      - confidence_score: 0
     - !!omap
       - id: "MAR06634"
       - name: ""
@@ -261104,16 +261116,16 @@
           - "Vitamin E metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR06477"
+      - id: "MAR06476"
       - name: ""
       - metabolites: !!omap
-          - MAM00356r: 1
-          - MAM01327r: -1
-          - MAM02039r: -1
-          - MAM02040r: 1
-          - MAM02554r: 1
-          - MAM02555r: -1
-          - MAM02630r: -1
+          - MAM00356c: 1
+          - MAM01327c: -1
+          - MAM02039c: -1
+          - MAM02040c: 1
+          - MAM02554c: 1
+          - MAM02555c: -1
+          - MAM02630c: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -261124,16 +261136,16 @@
           - "Vitamin E metabolism"
       - confidence_score: 0
     - !!omap
-      - id: "MAR06479"
+      - id: "MAR06478"
       - name: ""
       - metabolites: !!omap
-          - MAM00344r: 1
-          - MAM00356r: -1
-          - MAM02039r: -1
-          - MAM02040r: 3
-          - MAM02554r: 2
-          - MAM02555r: -2
-          - MAM02630r: -2
+          - MAM00344c: 1
+          - MAM00356c: -1
+          - MAM02039c: -1
+          - MAM02040c: 3
+          - MAM02554c: 2
+          - MAM02555c: -2
+          - MAM02630c: -2
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -261159,16 +261171,36 @@
           - "Transport reactions"
       - confidence_score: 0
     - !!omap
-      - id: "MAR00149"
+      - id: "MAR00145"
+      - name: "Fatty Acyl Coenzyme A Desaturase (N-C18:2CoA -> N-C18:3CoA)"
+      - metabolites: !!omap
+          - MAM00108c: 1
+          - MAM02039c: -1
+          - MAM02040c: 2
+          - MAM02390c: -1
+          - MAM02552c: 1
+          - MAM02553c: -1
+          - MAM02630c: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: ""
+      - rxnNotes: "reaction added by gap filling"
+      - eccodes: "1.14.19.1"
+      - references: ""
+      - subsystem:
+          - "Fatty acid biosynthesis"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR00151"
       - name: "Fatty Acyl Coenzyme A Desaturase (N-C18:1CoA -> N-C18:2CoA)"
       - metabolites: !!omap
+          - MAM00057c: -1
           - MAM00106c: 1
           - MAM02039c: -1
           - MAM02040c: 2
           - MAM02552c: 1
           - MAM02553c: -1
           - MAM02630c: -1
-          - MAM02647c: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: ""
@@ -261599,6 +261631,9 @@
     - !!omap
       - id: "CG10467"
       - name: "CG10467"
+    - !!omap
+      - id: "CG10483"
+      - name: "CG10483"
     - !!omap
       - id: "CG10486"
       - name: "CG10486"
@@ -261980,9 +262015,6 @@
     - !!omap
       - id: "CG1946"
       - name: "CG1946"
-    - !!omap
-      - id: "CG1983"
-      - name: "CG1983"
     - !!omap
       - id: "CG1986"
       - name: "CG1986"
@@ -262433,6 +262465,9 @@
     - !!omap
       - id: "CG5757"
       - name: "CG5757"
+    - !!omap
+      - id: "CG5793"
+      - name: "CG5793"
     - !!omap
       - id: "CG5808"
       - name: "CG5808"
@@ -262616,6 +262651,9 @@
     - !!omap
       - id: "CG7458"
       - name: "CG7458"
+    - !!omap
+      - id: "CG7536"
+      - name: "CG7536"
     - !!omap
       - id: "CG7550"
       - name: "CG7550"
diff --git a/model/dependencies.txt b/model/dependencies.txt
index 9389ee3..aba56d2 100644
--- a/model/dependencies.txt
+++ b/model/dependencies.txt
@@ -2,4 +2,4 @@ MATLAB	9.10.0.1602886 (R2021a)
 libSBML	5.19.0
 RAVEN_toolbox	2.7.6
 COBRA_toolbox	3.4.0
-Human-GEM	1.15.0
+Human-GEM	1.16.0
diff --git a/model/metabolites.tsv b/model/metabolites.tsv
index e77097d..9af5a9b 100644
--- a/model/metabolites.tsv
+++ b/model/metabolites.tsv
@@ -2224,9 +2224,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM01419e"	"camp"	"CHEBI:17489"	""	"HMDB0000058"	"m01419s"	"HC00434"	"C00575"	""	"MNXM243"	"6076"	"camp"	"m01419s"	"MAM01419"
 "MAM01420c"	"cbp"	"CHEBI:17672"	""	""	"m01420c"	"HC00164"	"C00169"	""	"MNXM138"	"278"	"cbp"	"m01420c"	"MAM01420"
 "MAM01420r"	"cbp"	"CHEBI:17672"	""	""	"m01420r"	"HC00164"	"C00169"	""	"MNXM138"	"278"	"cbp"	"m01420r"	"MAM01420"
-"MAM01421c"	"h2co3"	"CHEBI:28976"	""	""	"m01421c"	"HC02169"	"C01353"	""	"MNXM60"	""	"h2co3"	"m01421c"	"MAM01421"
-"MAM01421m"	"h2co3"	"CHEBI:28976"	""	""	"m01421m"	"HC02169"	"C01353"	""	"MNXM60"	""	"h2co3"	"m01421m"	"MAM01421"
-"MAM01421e"	"h2co3"	"CHEBI:28976"	""	""	"m01421s"	"HC02169"	"C01353"	""	"MNXM60"	""	"h2co3"	"m01421s"	"MAM01421"
 "MAM01422c"	"cbtnCCP"	""	""	""	"m01422c"	""	"C04419"	""	"MNXM5655"	""	""	"m01422c"	"MAM01422"
 "MAM01423c"	"carn"	"CHEBI:15727"	""	"HMDB0000033"	"m01423c"	"HC00321"	"C00386"	""	"MNXM114412;MNXM1419"	"439224"	"carn"	"m01423c"	"MAM01423"
 "MAM01424c"	"cdp"	"CHEBI:17239"	""	""	"m01424c"	"HC00110"	"C00112"	""	"MNXM220"	"6132"	"cdp"	"m01424c"	"MAM01424"
@@ -4051,7 +4048,8 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM02440e"	""	"CHEBI:30794"	""	"HMDB0000691"	"m02440s"	"HC00319"	"C00383"	""	"MNXM163844"	"867"	"HC00319"	"m02440s"	"MAM02440"
 "MAM02441c"	""	"CHEBI:566274"	"CE0737"	"HMDB0006112"	"m02441c"	""	"C19440"	""	"MNXM61004"	"10964"	"CE0737"	"m02441c"	"MAM02441"
 "MAM02442c"	"malACP"	""	""	""	"m02442c"	"HC00717"	"C01209"	""	"MNXM184"	""	"malACP"	"m02442c"	"MAM02442"
-"MAM02443c"	""	""	""	"HMDB0002095"	"m02443c"	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859"	"m02443c"	"MAM02443"
+"MAM02443e"	"c3dc"	""	""	"HMDB0002095"	""	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859;c3dc"	"c3dc_s"	"MAM02443"
+"MAM02443c"	"c3dc"	""	""	"HMDB0002095"	"m02443c"	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859;c3dc"	"m02443c;c3dc_c"	"MAM02443"
 "MAM02443m"	""	""	""	"HMDB0002095"	"m02443m"	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859"	"m02443m"	"MAM02443"
 "MAM02443x"	""	""	""	"HMDB0002095"	"m02443p"	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859"	"m02443p"	"MAM02443"
 "MAM02443r"	""	""	""	"HMDB0002095"	"m02443r"	"HC10859"	""	""	"MNXM162761"	"22833583"	"HC10859"	"m02443r"	"MAM02443"
@@ -5433,8 +5431,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03591g"	"glc1man"	""	""	""	""	""	""	""	"MNXM7382"	"440240"	"glc1man"	"glc1man_g"	"MAM03591"
 "MAM03592g"	"glc2man"	""	""	""	""	""	""	""	"MNXM13501"	""	"glc2man"	"glc2man_g"	"MAM03592"
 "MAM03593g"	"glc3man"	""	""	""	""	""	""	""	"MNXM18136"	""	"glc3man"	"glc3man_g"	"MAM03593"
-"MAM03573m"	"etfox"	""	""	""	""	""	""	""	"MNXM11479"	""	"etfox"	"etfox_m"	"MAM03573"
-"MAM03574m"	"etfrd"	""	""	""	""	""	""	""	"MNXM11480"	""	"etfrd"	"etfrd_m"	"MAM03574"
 "MAM01893e"	"1glyc_hs"	""	""	""	""	""	""	""	"MNXM13807"	""	"1glyc_hs"	"1glyc_hs_s"	"MAM01893"
 "MAM03315e"	"9_cis_retfa"	""	""	""	""	""	""	""	"MNXM146565"	""	"9_cis_retfa"	"9_cis_retfa_s"	"MAM03315"
 "MAM03577e"	"fucfuc12gal14acglcgalgluside_hs"	""	""	""	""	""	""	""	"MNXM8840"	""	"fucfuc12gal14acglcgalgluside_hs"	"fucfuc12gal14acglcgalgluside_hs_s"	"MAM03577"
@@ -5989,8 +5985,6 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM03250c"	"3octdec2crn"	""	""	""	""	""	""	""	""	""	"3octdec2crn"	"3octdec2crn_c"	"MAM03250"
 "MAM03230c"	"3hodcoa"	""	""	""	""	""	""	""	"MNXM31746"	"49859586"	"3hodcoa"	"3hodcoa_c"	"MAM03230"
 "MAM03251c"	"3octdeccrn"	""	""	""	""	""	""	""	""	""	"3octdeccrn"	"3octdeccrn_c"	"MAM03251"
-"MAM03494c"	"c3dc"	""	""	""	""	""	""	""	""	"22833583"	"c3dc"	"c3dc_c"	"MAM03494"
-"MAM03494e"	"c3dc"	""	""	""	""	""	""	""	""	"22833583"	"c3dc"	"c3dc_s"	"MAM03494"
 "MAM02635e"	""	""	""	"HMDB0002013"	""	"HC02150"	"C02862"	"LMFA07070003"	"MNXM65151"	"439829"	"c4crn"	"m02635s"	"MAM02635"
 "MAM03495x"	"c4dc"	""	""	""	""	""	""	""	"MNXM158939"	""	"c4dc"	"c4dc_p"	"MAM03495"
 "MAM03495c"	"c4dc"	""	""	""	""	""	""	""	"MNXM158939"	""	"c4dc"	"c4dc_c"	"MAM03495"
@@ -8091,6 +8085,43 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM20056r"	""	"CHEBI:83276"	""	""	""	""	""	""	"MNXM735429"	""	""	""	"MAM20056"
 "MAM00677r"	""	"CHEBI:15894"	""	""	""	""	"C03461"	""	"MNXM1959"	""	""	""	"MAM00677"
 "MAM20057c"	""	"CHEBI:83276"	""	""	""	""	""	""	"MNXM735429"	""	""	""	"MAM20057"
+"MAM20061c"	""	"CHEBI:133752"	""	""	""	""	"C21730"	""	"MNXM52422"	""	""	""	"MAM20061"
+"MAM20061n"	""	"CHEBI:133752"	""	""	""	""	"C21730"	""	"MNXM52422"	""	""	""	"MAM20061"
+"MAM01127n"	""	"CHEBI:18183"	""	""	""	""	"C01879"	""	"MNXM964"	""	""	""	"MAM01127"
+"MAM01806m"	""	"CHEBI:175763"	""	""	""	""	""	""	"MNXM1103344"	""	""	""	"MAM01806"
+"MAM20064m"	""	"CHEBI:60530"	""	""	""	""	""	""	"MNXM1107744"	""	""	""	"MAM20064"
+"MAM20064c"	""	"CHEBI:60530"	""	""	""	""	""	""	"MNXM1107744"	""	""	""	"MAM20064"
+"MAM01806n"	""	"CHEBI:175763"	""	""	""	""	""	""	"MNXM1103344"	""	""	""	"MAM01806"
+"MAM02049n"	""	"CHEBI:60344"	""	""	""	""	""	""	"MNXM249"	""	""	""	"MAM02049"
+"MAM20064n"	""	"CHEBI:60530"	""	""	""	""	""	""	"MNXM1107744"	""	""	""	"MAM20064"
+"MAM01657r"	""	"CHEBI:136960"	""	""	""	""	"C05859"	""	"MNXM1137698"	""	""	""	"MAM01657"
+"MAM01252n"	""	"CHEBI:30089"	""	""	""	""	""	""	"MNXM26"	""	""	""	"MAM01252"
+"MAM01288n"	""	"CHEBI:57967"	""	""	""	""	""	""	"MNXM1104545"	""	""	""	"MAM01288"
+"MAM20077n"	""	"CHEBI:83767"	""	""	""	""	""	""	"MNXM732228"	""	""	""	"MAM20077"
+"MAM02583n"	""	"CHEBI:17154"	""	""	""	""	""	""	"MNXM216"	""	""	""	"MAM02583"
+"MAM20063n"	""	"CHEBI:77017"	""	""	""	""	""	""	"MNXM166986"	""	""	""	"MAM20063"
+"MAM20066c"	""	"CHEBI:193091"	""	""	""	""	""	""	"MNXM819046"	""	""	""	"MAM20066"
+"MAM20065c"	""	"CHEBI:6746"	""	""	""	""	""	""	"MNXM3658"	""	""	""	"MAM20065"
+"MAM20066r"	""	"CHEBI:193091"	""	""	""	""	""	""	"MNXM819046"	""	""	""	"MAM20066"
+"MAM03590r"	""	"CHEBI:58756"	""	""	""	""	""	""	"MNXM728266"	""	""	""	"MAM03590"
+"MAM20065r"	""	"CHEBI:6746"	""	""	""	""	""	""	"MNXM3658"	""	""	""	"MAM20065"
+"MAM20066g"	""	"CHEBI:193091"	""	""	""	""	""	""	"MNXM819046"	""	""	""	"MAM20066"
+"MAM02759g"	""	"CHEBI:33019"	""	""	""	""	""	""	"MNXM11"	""	""	""	"MAM02759"
+"MAM03590g"	""	"CHEBI:58756"	""	""	""	""	""	""	"MNXM728266"	""	""	""	"MAM03590"
+"MAM20065g"	""	"CHEBI:6746"	""	""	""	""	""	""	"MNXM3658"	""	""	""	"MAM20065"
+"MAM20066n"	""	"CHEBI:193091"	""	""	""	""	""	""	"MNXM819046"	""	""	""	"MAM20066"
+"MAM03590n"	""	"CHEBI:58756"	""	""	""	""	""	""	"MNXM728266"	""	""	""	"MAM03590"
+"MAM20065n"	""	"CHEBI:6746"	""	""	""	""	""	""	"MNXM3658"	""	""	""	"MAM20065"
+"MAM00767c"	""	"CHEBI:84503"	""	""	""	""	""	""	"MNXM733937"	""	""	""	"MAM00767"
+"MAM00995r"	""	"CHEBI:17879"	""	""	""	""	""	""	"MNXM164"	""	""	""	"MAM00995"
+"MAM01316r"	""	"CHEBI:60721"	""	""	""	""	""	""	"MNXM731626"	""	""	""	"MAM01316"
+"MAM00767r"	""	"CHEBI:84503"	""	""	""	""	""	""	"MNXM733937"	""	""	""	"MAM00767"
+"MAM00995g"	""	"CHEBI:17879"	""	""	""	""	""	""	"MNXM164"	""	""	""	"MAM00995"
+"MAM01316g"	""	"CHEBI:60721"	""	""	""	""	""	""	"MNXM731626"	""	""	""	"MAM01316"
+"MAM00767g"	""	"CHEBI:84503"	""	""	""	""	""	""	"MNXM733937"	""	""	""	"MAM00767"
+"MAM00995n"	""	"CHEBI:17879"	""	""	""	""	""	""	"MNXM164"	""	""	""	"MAM00995"
+"MAM01316n"	""	"CHEBI:60721"	""	""	""	""	""	""	"MNXM731626"	""	""	""	"MAM01316"
+"MAM00767n"	""	"CHEBI:84503"	""	""	""	""	""	""	"MNXM733937"	""	""	""	"MAM00767"
 "MAM15003c"	""	"CHEBI:28718"	""	""	""	""	"C05519"	""	"MNXM2125"	"99289"	""	""	"MAM15003"
 "MAM01104x"	""	"CHEBI:250388"	""	""	""	""	"C11821"	""	"MNXM1137"	"250388"	""	""	"MAM01104"
 "MAM10018x"	""	"CHEBI:58639"	""	""	""	""	"C12248"	""	"MNXM1805"	"443736"	""	""	"MAM10018"
@@ -8127,9 +8158,9 @@ mets	metBiGGID	metChEBIID	metEHMNID	metHMDBID	metHMR2ID	metHepatoNET1ID	metKEGGI
 "MAM15052c"	""	"CHEBI:83276"	""	""	""	""	"C16502"	""	"MNXM735428"	"21895630"	""	""	"MAM15052"
 "MAM15053c"	""	"CHEBI:80535"	""	""	""	""	"C16503"	""	"MNXM5369"	"5275508"	""	""	"MAM15053"
 "MAM00809r"	"4mzym_int2"	"CHEBI:50593"	""	""	""	"HC02109"	"C15816"	"LMST01010167"	"MNXM162901;MNXM36392;MNXM8744"	""	"4mzym_int2"	"m00809r"	"MAM00809"
-"MAM01449r"	"zymstnl"	"CHEBI:16608"	""	"HMDB0006841"	""	"HC02126"	"C03845"	"LMST01010096"	"MNXM2494"	"101770"	"zymstnl"	"m01449r"	"MAM01449"
+"MAM01066r"	"chlstol"	"CHEBI:16290"	""	""	""	"HC01452"	"C05439"	""	"MNXM162749;MNXM830"	""	"chlstol"	"m01066r"	"MAM01066"
 "MAM02932r"	"Ssq23epx"	"CHEBI:15441"	""	""	""	"HC00645"	"C01054"	""	"MNXM130"	"53477723"	"Ssq23epx"	"m02932r"	"MAM02932"
-"MAM00356r"	""	""	"CE5842"	""	"m00356r"	""	""	""	"MNXM9688"	"53481465"	"CE5842"	"m00356r"	"MAM00356"
+"MAM00356c"	""	""	"CE5842"	""	"m00356c"	""	""	""	"MNXM9688"	"53481465"	"CE5842"	"m00356c"	"MAM00356"
 "MAM00360c"	""	""	"CE5655"	""	"m00360c"	""	""	""	"MNXM163114"	"53481467"	"CE5655"	"m00360c"	"MAM00360"
 "MAM01023r"	""	""	"CE5592"	""	"m01023r"	""	""	""	"MNXM164317"	""	"CE5592"	"m01023r"	"MAM01023"
 "MAM01598m"	"cbl1"	"CHEBI:15982"	""	""	"m01598m"	""	"C00853"	""	"MNXM91519"	""	"cbl1"	"m01598m"	"MAM01598"
diff --git a/model/reactions.tsv b/model/reactions.tsv
index 9e25016..224c62f 100644
--- a/model/reactions.tsv
+++ b/model/reactions.tsv
@@ -18,6 +18,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04368"	"PGK"	"R01512C"	"HMR_4368"	"r0337"	"R01512"	"MNXR102538"	""	"RCR10230"	"PGK"	"HMR_4368"	""	"RHEA:14801"	""	0
 "MAR04370"	"ACYP"	""	"HMR_4370"	""	"R01515"	"MNXR95410"	""	"RCR10445"	"ACYP"	"HMR_4370"	""	""	""	0
 "MAR04371"	""	""	"HMR_4371"	""	"R01662"	"MNXR107112"	""	"RCR11025"	"DPGM"	"HMR_4371"	""	"RHEA:17765"	""	0
+"MAR04372"	""	""	"HMR_4372"	""	"R01516"	"MNXR107035"	""	"RCR11026"	"DPGase"	"HMR_4372"	""	"RHEA:21904"	""	0
 "MAR04373"	"GAPD"	"R01061C"	"HMR_4373"	"r0253"	"R01061"	"MNXR100040"	""	"RCR11027"	"GAPD"	"HMR_4373"	""	"RHEA:10300"	""	0
 "MAR04375"	"FBA"	""	"HMR_4375"	"r0256"	"R01068"	"MNXR99459"	""	"RCR14183"	"FBA"	"HMR_4375"	""	"RHEA:14729"	""	0
 "MAR04377"	"FBP"	"R00762C"	"HMR_4377"	"r0487"	"R00762"	"MNXR106670;MNXR99465"	""	"RCR14184"	"FBP"	"HMR_4377"	""	"RHEA:11064"	""	0
@@ -457,7 +458,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR03822"	"P5CDm"	""	"HMR_3822"	""	"R00707"	"MNXR102301"	""	"RCR11243"	"P5CDm"	"HMR_3822"	""	"RHEA:16417"	""	0
 "MAR03827"	"ASPTAm"	"R00355C"	"HMR_3827"	"r0110"	"R00355"	"MNXR96079"	""	"RCR11244"	"ASPTAm"	"HMR_3827"	""	"RHEA:21824"	""	0
 "MAR03829"	"ASPTA"	"R00355C"	"HMR_3829"	"r0109"	"R00355"	"MNXR96079"	""	"RCR10118"	"ASPTA"	"HMR_3829"	""	"RHEA:21824"	""	0
-"MAR03831"	""	""	"HMR_3831"	""	"R00490"	""	""	"RCR10103"	"HMR_3831"	"HMR_3831"	""	"RHEA:16601"	""	0
 "MAR03862"	"ASNNm"	""	"HMR_3862"	""	"R00485"	"MNXR96056"	""	"RCR10305"	"ASNNm"	"HMR_3862"	""	"RHEA:21016"	""	0
 "MAR03865"	"3SALATAim"	""	"HMR_3865"	""	"R02619"	""	""	"RCR11245"	"3SALATAim"	"HMR_3865"	""	"RHEA:70295"	""	0
 "MAR03890"	"GLNS"	"R00253C"	"HMR_3890"	"r0077"	"R00253"	"MNXR100024"	""	"RCR10506"	"GLNS"	"HMR_3890"	""	"RHEA:16169"	""	0
@@ -1095,9 +1095,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04842"	""	""	"HMR_4842"	"r0800"	""	"MNXR105389"	""	"RCR14480"	"r0800"	"HMR_4842"	""	""	""	0
 "MAR08662"	"ITCOAL1m"	""	"HMR_8662"	""	"R02405"	"MNXR100883"	""	"RCR11651"	"ITCOAL1m"	"HMR_8662"	""	""	""	0
 "MAR08663"	"ITCOALm"	""	"HMR_8663"	""	"R02404"	"MNXR100884"	""	"RCR11652"	"ITCOALm"	"HMR_8663"	""	""	""	0
-"MAR08664"	"CITMCOALm"	""	"HMR_8664"	""	"R02491"	"MNXR96733"	""	"RCR10599"	"CITMCOAHm"	"HMR_8664"	""	""	""	0
+"MAR08664"	"CITMCOALm"	""	"HMR_8664"	""	"R02491"	"MNXR96733"	""	"RCR10599"	"CITMCOAHm"	"HMR_8664"	"RHEA:13787"	"RHEA:13785"	""	0
 "MAR08665"	"MGACONm"	""	"HMR_8665"	""	""	"MNXR101512"	""	"RCR11653"	"MGACONm"	"HMR_8665"	""	""	""	0
-"MAR08666"	"CITRtm"	""	"HMR_8666"	""	"R00237"	"MNXR96735"	""	"RCR10600"	"CITMCOALm"	"HMR_8666"	"RHEA:22613"	"RHEA:22612"	""	0
 "MAR08667"	"MECOALm"	""	"HMR_8667"	""	""	"MNXR101452"	""	"RCR11654"	"MECOALm"	"HMR_8667"	""	""	""	0
 "MAR08668"	"MECOAS1m"	""	"HMR_8668"	""	""	"MNXR101453"	""	"RCR11655"	"MECOAS1m"	"HMR_8668"	""	""	""	0
 "MAR08669"	"MESCOALm"	""	"HMR_8669"	""	""	"MNXR101469"	""	"RCR11656"	"MESCOALm"	"HMR_8669"	""	""	""	0
@@ -4139,13 +4138,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05127"	""	""	"HMR_5127"	"r1085"	""	""	""	"RCR14752"	""	"HMR_5127"	""	""	""	1
 "MAR05128"	"EX_nh4_e"	""	"HMR_5128"	"r1086"	""	"MNXR98786"	""	"RCR30284"	""	"HMR_5128"	""	""	""	0
 "MAR05363"	"PPA2"	""	"HMR_5363"	"r1296"	"R00138"	"MNXR103069"	""	"RCR11008"	"PPA2"	"HMR_5363"	""	"RHEA:14157"	""	0
-"MAR05406"	"H2CO3D"	""	"HMR_5406"	"r1417"	"R00132"	"MNXR100482"	""	"RCR14126"	"H2CO3D"	"HMR_5406"	""	"RHEA:10748"	""	0
-"MAR05409"	""	""	"HMR_5409"	"r1420"	""	""	""	"RCR30285"	"HMR_5409"	"HMR_5409"	""	""	""	0
 "MAR07794"	"PPAn"	""	"HMR_7794"	""	"R00004"	"MNXR100808"	""	"RCR10436"	"PPAn"	"HMR_7794"	"RHEA:24577"	"RHEA:24576"	""	0
 "MAR08617"	"PPA2m"	""	"HMR_8617"	""	"R00138"	"MNXR103069"	""	"RCR14127"	"PPA2m"	"HMR_8617"	""	"RHEA:14157"	""	0
-"MAR08749"	"H2CO3D2"	""	"HMR_8749"	""	""	"MNXR100483"	""	"RCR14128"	"HMR_8749"	"HMR_8749"	""	""	""	1
-"MAR08750"	"H2CO3D2m"	""	"HMR_8750"	""	""	"MNXR100483"	""	"RCR14129"	"HMR_8750"	"HMR_8750"	""	""	""	1
-"MAR08751"	"H2CO3Dm"	""	"HMR_8751"	""	"R00132"	"MNXR100482"	""	"RCR14130"	"H2CO3Dm"	"HMR_8751"	""	"RHEA:10748"	""	0
 "MAR08752"	"PRDXl"	""	"HMR_8752"	""	""	"MNXR103159"	""	"RCR14131"	"PRDXl"	"HMR_8752"	"RHEA:30692"	"RHEA:30691"	""	0
 "MAR07741"	""	""	"HMR_7741"	""	"R01195"	"MNXR99609"	""	"RCR14753"	"HMR_7741"	"HMR_7741"	""	"RHEA:20125"	""	0
 "MAR09464"	""	""	"HMR_9464"	""	"R01791"	"MNXR107171"	""	"RCR14754"	"HMR_9464"	"HMR_9464"	""	""	""	0
@@ -4502,7 +4496,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05240"	""	""	"HMR_5240"	""	""	""	""	"RCR40149"	"HMR_5240"	"HMR_5240"	""	""	""	0
 "MAR05241"	""	""	"HMR_5241"	"r1084"	""	""	""	"RCR40150"	"HMR_5241"	"HMR_5241"	""	""	""	0
 "MAR05246"	""	""	"HMR_5246"	""	""	""	""	"RCR40482"	"HMR_5246"	"HMR_5246"	""	""	""	0
-"MAR05295"	""	""	"HMR_5295"	"r1110"	""	""	""	"RCR41002"	"NaKt"	"HMR_5295"	""	""	""	0
 "MAR05296"	"MEOHt2"	""	"HMR_5296"	"r1111"	""	"MNXR101464"	""	"RCR40483"	"MEOHt2"	"HMR_5296"	"RHEA:34874"	"RHEA:34871"	""	0
 "MAR05303"	""	""	"HMR_5303"	"r1116"	""	"MNXR96140"	""	"RCR40226"	"r1116"	"HMR_5303"	""	""	""	0
 "MAR05305"	"ALAt4"	""	"HMR_5305"	"r1118"	""	"MNXR95692"	""	"RCR41003"	"ALAt4"	"HMR_5305"	""	""	"2.A.18.6.7"	0
@@ -4521,8 +4514,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05328"	"r1143"	""	"HMR_5328"	"r1143"	""	"MNXR96086"	""	"RCR41019"	"r1143"	"HMR_5328"	""	""	"2.A.18.6.3"	0
 "MAR05330"	"GLUt4"	""	"HMR_5330"	"r1144"	""	"MNXR100285"	""	"RCR41020"	"r1144"	"HMR_5330"	""	""	"2.A.18.6.3"	0
 "MAR05332"	"GLUVESSEC"	""	"HMR_5332"	""	""	"MNXR100297"	""	"RCR40227"	"GLUVESSEC"	"HMR_5332"	""	""	""	0
-"MAR05333"	"HISt4"	""	"HMR_5333"	"r1145"	""	"MNXR100646"	""	"RCR41021"	"HISt4"	"HMR_5333"	""	""	"2.A.18.6.5"	0
-"MAR05413"	"PIt2r"	""	"HMR_5413"	""	""	"MNXR102872"	""	"RCR41023"	"PIt6b"	"HMR_5413"	"RHEA:29941"	"RHEA:29939"	""	0
 "MAR05429"	"NaKt"	""	"HMR_5429"	"r1489"	""	"MNXR102073"	""	"RCR41024"	""	"HMR_5429"	""	""	"3.A.3.1.1"	0
 "MAR05430"	"NAt3_1"	""	"HMR_5430"	"r1490"	""	"MNXR101803"	""	"RCR41025"	"NAt3_1"	"HMR_5430"	""	""	"2.A.36.1.1"	0
 "MAR05432"	"HCO3_NAt"	""	"HMR_5432"	"r1491"	""	"MNXR100485"	""	"RCR41026"	"HCO3_NAt"	"HMR_5432"	""	""	"2.A.31.2.1"	0
@@ -5383,11 +5374,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR06375"	"SERt4"	""	"HMR_6375"	"r2474"	""	"MNXR104346"	""	"RCR41525"	"SERt4"	"HMR_6375"	""	""	"2.A.18.6.5"	0
 "MAR06377"	"CYSt4"	""	"HMR_6377"	"r2475"	""	"MNXR97028"	""	"RCR41526"	"CYSt4"	"HMR_6377"	""	""	"2.A.18.6.5"	0
 "MAR06379"	"HOMt4"	""	"HMR_6379"	"r2476"	""	"MNXR100677"	""	"RCR41527"	"HOMt4"	"HMR_6379"	""	""	"2.A.18.6.5"	0
-"MAR06380"	"GLNt4"	""	"HMR_6380"	"r2477"	""	"MNXR100261"	""	"RCR41528"	""	"HMR_6380"	""	""	"2.A.18.6.2"	0
-"MAR06381"	"SERt4"	""	"HMR_6381"	"r2478"	""	"MNXR104346"	""	"RCR41529"	""	"HMR_6381"	""	""	"2.A.18.6.8"	0
-"MAR06382"	"ASNt4"	""	"HMR_6382"	"r2479"	""	"MNXR96057"	""	"RCR41530"	""	"HMR_6382"	""	""	"2.A.18.6.8"	0
 "MAR06383"	"HOMt4"	""	"HMR_6383"	"r2480"	""	"MNXR100677"	""	"RCR41531"	""	"HMR_6383"	""	""	"2.A.18.6.8"	0
-"MAR06384"	"HISt4"	""	"HMR_6384"	"r2481"	""	"MNXR100646"	""	"RCR41532"	"HISSNAT5tc"	"HMR_6384"	""	""	"2.A.18.6.2"	0
 "MAR06392"	""	""	"HMR_6392"	"r2505"	""	"MNXR106316"	""	"RCR41533"	"r2505"	"HMR_6392"	""	""	"3.A.1.208.8"	0
 "MAR06406"	"LIPOti"	"RT1089"	"HMR_6406"	""	""	"MNXR101093"	""	"RCR41534"	""	"HMR_6406"	""	""	""	0
 "MAR06424"	"AVITE2t"	"RT1352"	"HMR_6424"	""	""	"MNXR96147"	""	"RCR40703"	"AVITE2t"	"HMR_6424"	""	""	""	0
@@ -6543,7 +6530,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR01809"	"XOLTRIOLtm"	""	"HMR_1809"	""	""	"MNXR105242"	""	"RCR20944"	"XOLTRIOLtr"	"HMR_1809"	""	""	""	0
 "MAR00020"	""	""	"HMR_0020"	""	""	""	""	"RCR20211"	"HMR_0020"	"HMR_0020"	""	""	""	0
 "MAR00462"	""	""	"HMR_0462"	"r1282"	""	""	""	"RCR20157"	"HMR_0462"	"HMR_0462"	""	""	""	0
-"MAR00464"	"PE_HStg"	""	"HMR_0464"	"r1268"	""	"MNXR102505"	""	"RCR21117"	"PE_HSter"	"HMR_0464"	""	""	""	0
 "MAR00466"	"PS_HStg"	""	"HMR_0466"	"r1271"	""	"MNXR103316"	""	"RCR21118"	"PS_HSter"	"HMR_0466"	""	""	""	0
 "MAR00467"	""	""	"HMR_0467"	"r1273"	""	""	""	"RCR20356"	"HMR_0467"	"HMR_0467"	""	""	""	0
 "MAR00664"	""	""	"HMR_0664"	"r1264"	""	""	""	"RCR20946"	"HMR_0664"	"HMR_0664"	""	""	""	0
@@ -7188,7 +7174,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00064"	"ADRNCRNt"	""	""	""	""	"MNXR95487"	""	""	"ADRNCRNt"	"ADRNCRNt"	""	""	""	0
 "MAR00065"	"ADRNLPVESSEC"	""	""	""	""	"MNXR95488"	""	""	"ADRNLPVESSEC"	"ADRNLPVESSEC"	""	""	""	0
 "MAR00066"	"ALAt2rL"	""	""	""	""	"MNXR95704"	""	""	"ALAt2rL"	"ALAt2rL"	""	""	""	0
-"MAR00067"	"ALDD21"	""	""	""	""	"MNXR95747"	""	""	"ALDD21"	"ALDD21"	""	""	""	0
+"MAR00067"	"ALDD21;RE3076X;R_ALDD21;R_RE3076X"	""	""	""	""	"MNXR95747"	""	""	"ALDD21"	"ALDD21"	"RHEA:44016"	""	""	0
 "MAR00068"	"ALKP"	""	""	""	""	"MNXR95764"	""	""	"ALKP"	"ALKP"	""	""	""	0
 "MAR00069"	"AMACR2p"	""	""	""	""	"MNXR95798"	""	""	"AMACR2p"	"AMACR2p"	""	""	""	0
 "MAR00070"	"AMACR2r"	""	""	""	""	"MNXR95798"	""	""	"AMACR2r"	"AMACR2r"	""	""	""	0
@@ -7292,8 +7278,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR00480"	"ENMAN4g"	""	""	""	""	"MNXR97929"	""	""	"ENMAN4g"	"ENMAN4g"	""	""	""	0
 "MAR00485"	"ENMAN5g"	""	""	""	""	"MNXR97930"	""	""	"ENMAN5g"	"ENMAN5g"	""	""	""	0
 "MAR00554"	"ENMAN6g"	""	""	""	""	"MNXR97931"	""	""	"ENMAN6g"	"ENMAN6g"	""	""	""	0
-"MAR00562"	"ETF"	""	""	""	""	"MNXR97965"	""	""	"ETF"	"ETF"	""	""	""	0
-"MAR00563"	"ETFQO"	""	""	""	""	"MNXR97966"	""	""	"ETFQO"	"ETFQO"	""	""	""	0
 "MAR00564"	"EX_1glyc_hs_e"	""	""	""	""	"MNXR97997"	""	""	"EX_1glyc_hs[e]"	"EX_1glyc_hs[e]"	""	""	""	0
 "MAR00565"	"EX_9_cis_retfa_e"	""	""	""	""	"MNXR98098"	""	""	"EX_9_cis_retfa[e]"	"EX_9_cis_retfa[e]"	""	""	""	0
 "MAR00566"	"EX_adrn_e"	""	""	""	""	"MNXR98235"	""	""	"EX_adrn[e]"	"EX_adrn[e]"	""	""	""	0
@@ -7740,7 +7724,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR02477"	"r2515"	""	""	""	""	"MNXR106325"	""	""	"r2515"	"r2515"	""	""	""	0
 "MAR02479"	"r2537"	""	""	""	""	"MNXR101111"	""	""	"r2537"	"r2537"	""	""	""	0
 "MAR02481"	"r2538"	""	""	""	""	"MNXR106330"	""	""	"r2538"	"r2538"	""	""	""	0
-"MAR02490"	""	""	""	""	""	""	""	""	"RE0456M"	"RE0456M"	""	""	""	0
 "MAR02492"	"RE0512C"	""	""	""	""	"MNXR103448"	""	""	"RE0512C"	"RE0512C"	""	""	""	0
 "MAR02494"	"RE0569E"	""	""	""	""	"MNXR103454"	""	""	"RE0569E"	"RE0569E"	"RHEA:35328"	"RHEA:35327"	""	0
 "MAR02496"	"RE0572N"	""	""	""	""	"MNXR103457"	""	""	"RE0572N"	"RE0572N"	"RHEA:39194"	"RHEA:39191"	""	0
@@ -8140,7 +8123,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04405"	"EX_CE5853_e"	""	""	""	""	"MNXR98128"	""	""	"EX_CE5853[e]"	"EX_CE5853[e]"	""	""	""	0
 "MAR04407"	"EX_CE1925_e"	""	""	""	""	"MNXR98104"	""	""	"EX_CE1925[e]"	"EX_CE1925[e]"	""	""	""	0
 "MAR04409"	"EX_C04849_e"	""	""	""	""	"MNXR98102"	""	""	"EX_C04849[e]"	"EX_C04849[e]"	""	""	""	0
-"MAR04411"	"PIt8"	""	"HMR_4911"	""	""	"MNXR102875"	""	"RCR40976"	"PIt8"	"PIt8"	""	""	""	0
 "MAR04413"	""	""	""	""	""	""	""	""	""	"biomass_Recon3D"	""	""	""	0
 "MAR04438"	"2MB2COAc"	""	""	""	""	"MNXR94807"	""	""	"2MB2COAc"	"2MB2COAc"	""	""	""	0
 "MAR04439"	"3HBCOARc"	""	""	""	""	"MNXR94892"	""	""	"3HBCOARc"	"3HBCOARc"	""	""	""	0
@@ -8158,7 +8140,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR04511"	"C12DCACT"	""	""	""	""	""	""	""	"C12DCACT"	"C12DCACT"	""	""	""	0
 "MAR04515"	"C12DCTD"	""	""	""	""	""	""	""	"C12DCTD"	"C12DCTD"	""	""	""	0
 "MAR04522"	"C12OHc"	""	""	""	""	"MNXR96379"	""	""	"C12OHc"	"C12OHc"	""	""	""	0
-"MAR04562"	"TTDCPT1"	""	""	""	""	"MNXR104972"	""	""	"C140CPT1"	"C140CPT1"	""	""	""	0
 "MAR04566"	"C141ACBP"	""	""	""	""	""	""	""	"C141ACBP"	"C141ACBP"	""	""	""	0
 "MAR04569"	"C141CPT1"	""	""	""	""	""	""	""	"C141CPT1"	"C141CPT1"	""	""	""	0
 "MAR04571"	"C141OHc"	""	""	""	""	""	""	""	"C141OHc"	"C141OHc"	""	""	""	0
@@ -8342,12 +8323,11 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR05421"	"FAOXC22C20x"	""	""	""	""	""	""	""	"FAOXC22C20x"	"FAOXC22C20x"	""	""	""	0
 "MAR05428"	"FAOXC241C221x"	""	""	""	""	""	""	""	"FAOXC241C221x"	"FAOXC241C221x"	""	""	""	0
 "MAR05431"	"FAOXC24C22x"	""	""	""	""	""	""	""	"FAOXC24C22x"	"FAOXC24C22x"	""	""	""	0
-"MAR05434"	"FAOXC3DC"	""	""	""	""	""	""	""	"FAOXC3DC"	"FAOXC3DC"	""	""	""	0
 "MAR05449"	"FAOXC4020m"	""	""	""	""	"MNXR99368"	""	""	"FAOXC4C2m"	"FAOXC4C2m"	""	""	""	0
 "MAR05456"	"FAOXC4C4DCc"	""	""	""	""	""	""	""	"FAOXC4C4DCc"	"FAOXC4C4DCc"	""	""	""	0
 "MAR05988"	"FAOXC5C3x"	""	""	""	""	""	""	""	"FAOXC5C3x"	"FAOXC5C3x"	""	""	""	0
 "MAR05991"	"FAOXC5C5DCc"	""	""	""	""	""	""	""	"FAOXC5C5DCc"	"FAOXC5C5DCc"	""	""	""	0
-"MAR05999"	"FAOXC5C5OHm"	""	""	""	""	""	""	""	"FAOXC5C5OHm"	"FAOXC5C5OHm"	""	""	""	0
+"MAR05999"	"FAOXC5C5OHm"	""	""	""	""	""	""	""	"FAOXC5C5OHm"	"FAOXC5C5OHm"	"RHEA:31081"	"RHEA:31079"	""	0
 "MAR06278"	"FAOXC5OHc"	""	""	""	""	""	""	""	"FAOXC5OHc"	"FAOXC5OHc"	""	""	""	0
 "MAR06279"	"FAOXC61C4m"	""	""	""	""	""	""	""	"FAOXC61C4m"	"FAOXC61C4m"	""	""	""	0
 "MAR06280"	"FAOXC61C4x"	""	""	""	""	""	""	""	"FAOXC61C4x"	"FAOXC61C4x"	""	""	""	0
@@ -8538,13 +8518,11 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08982"	"NADtm"	""	""	""	""	"MNXR101900"	""	""	"NADtm"	"NADtm"	""	""	""	0
 "MAR08983"	"OCDCAFATPc"	""	""	""	""	"MNXR102141"	""	""	"OCDCAFATPc"	"OCDCAFATPc"	""	""	""	0
 "MAR08984"	"PAN4PPe"	""	""	""	""	"MNXR102343"	""	""	"PAN4PPe"	"PAN4PPe"	""	""	""	0
-"MAR08985"	"PGLc"	""	""	""	""	""	""	""	"PGLc"	"PGLc"	""	""	""	0
 "MAR08986"	"PNTEHe"	""	""	""	""	"MNXR103049"	""	""	"PNTEHe"	"PNTEHe"	""	""	""	0
 "MAR08987"	"PPItm"	""	""	""	""	"MNXR103112"	""	""	"PPItm"	"PPItm"	""	""	""	0
 "MAR08988"	"PRO_Dtde"	""	""	""	""	"MNXR103209"	""	""	"PRO_Dtde"	"PRO_Dtde"	""	""	""	0
 "MAR08989"	"PTRCtex2"	""	""	""	""	"MNXR103339"	""	""	"PTCRTD"	"PTCRTD"	""	""	""	0
 "MAR08991"	"Q10H2e"	""	""	""	""	"MNXR103390"	""	""	"Q10H2e"	"Q10H2e"	""	""	""	0
-"MAR08992"	"RPEc"	""	""	""	""	""	""	""	"RPEc"	"RPEc"	""	""	""	0
 "MAR08993"	"SFCYSc"	""	""	""	""	"MNXR104355"	""	""	"SFCYSc"	"SFCYSc"	""	""	""	0
 "MAR08994"	"SFCYSe"	""	""	""	""	"MNXR104356"	""	""	"SFCYSe"	"SFCYSe"	""	""	""	0
 "MAR08995"	"TAURt"	""	""	""	""	"MNXR104733"	""	""	"TAURCHAe"	"TAURCHAe"	""	""	""	0
@@ -9058,7 +9036,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR10407"	"TXB2t"	""	""	""	""	"MNXR163125"	""	""	"TXB2t"	"TXB2t"	""	""	""	0
 "MAR10408"	"URCANt"	""	""	""	""	""	""	""	"URCANt"	"URCANt"	""	""	""	0
 "MAR10409"	"WHARACHDt"	""	""	""	""	""	""	""	"WHARACHDt"	"WHARACHDt"	""	""	""	0
-"MAR10410"	""	""	""	""	""	""	""	""	"WHARACHDtd"	"WHARACHDtd"	""	""	""	0
 "MAR10411"	"WHARACHDtr"	""	""	""	""	""	""	""	"WHARACHDtr"	"WHARACHDtr"	""	""	""	0
 "MAR10412"	"ACILEm"	""	""	""	""	""	""	""	"ACILEm"	"ACILEm"	""	""	""	0
 "MAR10413"	"ACILEtm"	""	""	""	""	""	""	""	"ACILEtm"	"ACILEtm"	""	""	""	0
@@ -9951,7 +9928,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11307"	"5AOPt2"	""	""	""	""	"MNXR95061"	""	""	"5AOPt2"	"5AOPt2"	""	""	""	0
 "MAR11308"	"ACNAMt2"	""	""	""	""	"MNXR95291"	""	""	"ACNAMt2"	"ACNAMt2"	"RHEA:28989"	"RHEA:28987"	""	0
 "MAR11309"	"BANDMT"	""	""	""	""	"MNXR96213"	""	""	"BANDMT"	"BANDMT"	""	""	""	0
-"MAR11310"	"C181CPT2rbc"	""	""	""	""	"MNXR96396"	""	""	"C181CPT2rbc"	"C181CPT2rbc"	""	""	""	0
 "MAR11311"	"CA2t"	""	""	""	""	"MNXR96436"	""	""	"CA2t"	"CA2t"	""	""	""	0
 "MAR11312"	"GTHOXti2"	""	""	""	""	"MNXR100444"	""	""	"GTHOXti2"	"GTHOXti2"	""	""	""	0
 "MAR11313"	"HCYSte"	""	""	""	""	"MNXR100580"	""	""	"HCYSte"	"HCYSte"	""	""	""	0
@@ -10147,7 +10123,7 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR11511"	"TIGGLYte"	""	""	""	""	""	""	""	"TIGGLYte"	"TIGGLYte"	""	""	""	0
 "MAR11512"	"EX_tiggly_e"	""	""	""	""	""	""	""	"EX_tiggly[e]"	"EX_tiggly[e]"	""	""	""	0
 "MAR11513"	"TD2GLTRCOAm"	""	""	""	""	""	""	""	"TD2GLTRCOAm"	"TD2GLTRCOAm"	""	""	""	0
-"MAR11514"	"3HGLUTCOAm"	""	""	""	""	""	""	""	"3HGLUTCOAm"	"3HGLUTCOAm"	""	""	""	0
+"MAR11514"	"3HGLUTCOAm"	""	""	""	""	""	""	""	"3HGLUTCOAm"	"3HGLUTCOAm"	"RHEA:68458"	"RHEA:68456"	""	0
 "MAR11515"	"3OHGLUTACm"	""	""	""	""	""	""	""	"3OHGLUTACm"	"3OHGLUTACm"	""	""	""	0
 "MAR11516"	"3OHGLUTACtm"	""	""	""	""	""	""	""	"3OHGLUTACtm"	"3OHGLUTACtm"	""	""	""	0
 "MAR11517"	"3OHGLUTACte"	""	""	""	""	""	""	""	"3OHGLUTACte"	"3OHGLUTACte"	""	""	""	0
@@ -11648,7 +11624,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR13063"	"EX_M03153_e"	""	""	""	""	""	""	""	"EX_M03153[e]"	"EX_M03153[e]"	""	""	""	0
 "MAR13064"	""	""	""	""	""	""	""	""	"EX_M01268[e]"	"EX_M01268[e]"	""	""	""	0
 "MAR13065"	""	""	""	""	""	""	""	""	"EX_HC02080[e]"	"EX_HC02080[e]"	""	""	""	0
-"MAR13066"	"EX_h2co3_e"	""	""	""	""	"MNXR98639"	""	""	"EX_h2co3[e]"	"EX_h2co3[e]"	""	""	""	0
 "MAR13067"	"EX_M02837_e"	""	""	""	""	""	""	""	"EX_M02837[e]"	"EX_M02837[e]"	""	""	""	0
 "MAR13068"	""	""	""	""	""	""	""	""	"EX_M02382[e]"	"EX_M02382[e]"	""	""	""	0
 "MAR13069"	""	""	""	""	""	""	""	""	"EX_M02035[e]"	"EX_M02035[e]"	""	""	""	0
@@ -11776,7 +11751,6 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20001"	"HMR_6633;RDH1;R_HMR_6633;R_RDH1;R_TRETINOLOR1;TRETINOLOR1"	""	""	""	"R02124"	"MNXR189842"	""	""	""	""	"RHEA:21284"	""	""	0
 "MAR20002"	"HMR_6633;RDH1;R_HMR_6633;R_RDH1;R_TRETINOLOR1;TRETINOLOR1"	""	""	""	"R02124"	"MNXR189842"	""	""	""	""	"RHEA:21284"	""	""	0
 "MAR20003"	"RDH2;R_RDH2"	""	""	""	"R08382"	"MNXR103441"	""	""	""	""	"RHEA:42052"	""	""	0
-"MAR20004"	"RDH2;R_RDH2"	""	""	""	"R08382"	"MNXR103441"	""	""	""	""	"RHEA:42052"	""	""	0
 "MAR20005"	""	""	""	""	""	"MNXR167709"	""	""	""	""	"RHEA:39803"	""	""	0
 "MAR20006"	""	""	""	""	""	"MNXR167709"	""	""	""	""	"RHEA:39803"	""	""	0
 "MAR20007"	""	""	""	""	""	"MNXR167708"	""	""	""	""	"RHEA:39799"	""	""	0
@@ -11799,14 +11773,12 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20042"	""	""	""	""	""	"MNXR133378"	""	""	""	""	"RHEA:59916"	""	""	0
 "MAR20043"	""	""	""	""	""	"MNXR171404"	""	""	""	""	"RHEA:59920"	""	""	0
 "MAR20044"	""	""	""	""	"R07140"	"MNXR110840"	""	""	""	""	"RHEA:19981"	""	""	0
-"MAR20045"	"FALDH2;R_FALDH2;R_r1378;r1378"	""	""	""	"R06983"	"MNXR146812"	""	""	""	""	"RHEA:19985"	""	""	0
 "MAR20046"	""	""	""	""	""	"MNXR120270"	""	""	""	""	"RHEA:36135"	""	""	0
 "MAR20047"	""	""	""	""	""	"MNXR120270"	""	""	""	""	"RHEA:36135"	""	""	0
 "MAR20048"	"ALDD16;R_ALDD16"	""	""	""	"R01704"	"MNXR95739"	""	""	""	""	"RHEA:33739"	""	""	0
 "MAR20049"	""	""	""	""	""	"MNXR167567"	""	""	""	""	"RHEA:39015"	""	""	0
 "MAR20050"	""	""	""	""	""	"MNXR167567"	""	""	""	""	"RHEA:39015"	""	""	0
 "MAR20051"	"ALDD21;RE3076X;R_ALDD21;R_RE3076X"	""	""	""	""	"MNXR95747"	""	""	""	""	"RHEA:44016"	""	""	0
-"MAR20052"	"ALDD21;RE3076X;R_ALDD21;R_RE3076X"	""	""	""	""	"MNXR95747"	""	""	""	""	"RHEA:44016"	""	""	0
 "MAR20053"	"ALDD18;R_ALDD18"	""	""	""	""	"MNXR95741"	""	""	""	""	"RHEA:44020"	""	""	0
 "MAR20054"	"ALDD18;R_ALDD18"	""	""	""	""	"MNXR95741"	""	""	""	""	"RHEA:44020"	""	""	0
 "MAR20055"	"ALDD12;R_ALDD12"	""	""	""	""	"MNXR95735"	""	""	""	""	"RHEA:44168"	""	""	0
@@ -11823,6 +11795,24 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR20066"	"CAT;CATm;CATp;CATpp;CATr;R_CAT;R_CATm;R_CATp;R_CATpp;R_CATr"	""	""	""	"R00009"	"MNXR96455"	""	""	""	""	"RHEA:20309"	""	""	0
 "MAR20069"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
 "MAR20070"	""	""	""	""	""	""	""	""	""	""	""	""	""	0
+"MAR20071"	""	""	""	""	"R00490"	"MNXR165843"	""	""	""	""	"RHEA:16962"	""	""	0
+"MAR20072"	""	""	""	""	"R00490"	"MNXR165843"	""	""	""	""	"RHEA:16962"	""	""	0
+"MAR20089"	""	""	""	""	"R02701"	"MNXR151808"	""	""	""	""	"RHEA:18533"	""	""	0
+"MAR20090"	"HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1"	""	""	""	"R07411"	"MNXR115959"	""	""	""	""	"RHEA:28070"	""	""	0
+"MAR20091"	"HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1"	""	""	""	"R07411"	"MNXR115959"	""	""	""	""	"RHEA:28070"	""	""	0
+"MAR20092"	"HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1"	""	""	""	"R07411"	"MNXR115959"	""	""	""	""	"RHEA:28070"	""	""	0
+"MAR20098"	""	""	""	""	""	""	""	""	""	""	"RHEA:53008"	""	""	0
+"MAR20099"	""	""	""	""	"R12391"	"MNXR123366"	""	""	""	""	"RHEA:57060"	""	""	0
+"MAR20100"	""	""	""	""	""	""	""	""	""	""	"RHEA:68792"	""	""	0
+"MAR20102"	""	""	""	""	""	""	""	""	""	""	"RHEA:74083"	""	""	0
+"MAR20103"	""	""	""	""	""	""	""	""	""	""	"RHEA:74083"	""	""	0
+"MAR20104"	""	""	""	""	""	""	""	""	""	""	"RHEA:74083"	""	""	0
+"MAR20105"	""	""	""	""	""	""	""	""	""	""	"RHEA:74083"	""	""	0
+"MAR20106"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
+"MAR20107"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
+"MAR20108"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
+"MAR20109"	"HBZOPT10m;R_HBZOPT10m"	""	""	""	""	"MNXR100567"	""	""	""	""	"RHEA:44564"	""	""	0
+"MAR20110"	""	""	""	""	""	"MNXR102097"	""	""	""	""	"RHEA:15642"	"RHEA:15641"	""	0
 "MAR15001"	""	""	""	""	"R01465"	"MNXR103402"	"R-HSA-6798667"	""	""	""	""	""	""	0
 "MAR15003"	""	""	""	""	"R06171"	"MNXR104834"	""	""	""	""	""	""	""	0
 "MAR15004"	""	""	""	""	"R06601"	"MNXR100652"	""	""	""	""	""	""	""	0
@@ -11854,23 +11844,21 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR15053"	""	""	""	""	"R03738"	"MNXR108386"	""	""	""	""	""	""	""	0
 "MAR15054"	""	""	""	""	"R11916"	"MNXR170522"	""	""	""	""	""	""	""	0
 "MAR15055"	""	""	""	""	"R03984"	"MNXR152018"	""	""	""	""	""	""	""	0
-"MAR00114"	"C3STDH1r"	""	""	""	""	"MNXR96410"	""	""	"C3STDH1r"	"C3STDH1r"	""	""	""	0
-"MAR00118"	"C4STMO2r"	""	""	""	""	"MNXR96420"	""	""	"C4STMO2r"	"C4STMO2r"	""	""	""	0
+"MAR00113"	"C3STDH1Pr"	""	""	""	""	"MNXR95038"	""	""	"C3STDH1Pr"	"C3STDH1Pr"	""	""	""	0
+"MAR00222"	"DHCR243r"	""	""	""	""	"MNXR97382"	""	""	"DHCR243r"	"DHCR243r"	""	""	""	0
+"MAR00443"	"EBP1r"	""	""	""	""	"MNXR96689"	""	""	"EBP1r"	"EBP1r"	""	""	""	0
 "MAR01498"	"LNSTLSr"	""	""	""	""	"MNXR101117"	""	""	"LNSTLSr"	"LNSTLSr"	""	""	""	0
-"MAR01510"	"LSTO2r"	""	""	""	""	"MNXR101245"	""	""	"LSTO2r"	"LSTO2r"	""	""	""	0
+"MAR01508"	"LSTO1r"	""	""	""	""	"MNXR101244"	""	""	"LSTO1r"	"LSTO1r"	""	""	""	0
 "MAR01714"	"SQLEr"	""	""	""	""	"MNXR104447"	""	""	"SQLEr"	"SQLEr"	""	""	""	0
 "MAR01715"	"SQLSr"	""	""	""	""	"MNXR104529"	""	""	"SQLSr"	"SQLSr"	""	""	""	0
 "MAR02200"	"LNS14DMr"	""	""	""	""	"MNXR101115"	""	""	"r0781"	"r0781"	""	""	""	0
-"MAR02337"	"r1380"	""	""	""	""	"MNXR105284"	""	""	"r1380"	"r1380"	""	""	""	0
-"MAR02339"	"EBP2r"	""	""	""	""	"MNXR96687"	""	""	"EBP2r;r1381"	"r1381"	""	""	""	0
+"MAR02301"	"r1135"	""	""	""	""	""	""	""	"r1135"	"r1135"	""	""	""	0
 "MAR05151"	""	""	"HMR_5151"	"r1092"	""	""	""	"RCR14453"	"HMR_5151;r1092"	"HMR_5151"	""	""	""	0
-"MAR04106"	"MCDm"	""	"HMR_4106"	"r0064"	"R00233"	"MNXR101412"	""	"RCR11089"	"MCDm"	"HMR_4106"	"RHEA:18782"	"RHEA:18781"	""	0
+"MAR04497"	""	""	"HMR_4497"	"r0365"	"R01608"	"MNXR94902"	""	"RCR10463"	"r0365"	"HMR_4497"	""	"RHEA:13357"	""	0
 "MAR04861"	"INSTt2"	""	"HMR_4861"	"r0827"	""	"MNXR100841"	""	"RCR40440"	""	"HMR_4861"	"RHEA:60367"	"RHEA:60364"	""	0
-"MAR04485"	"TMDPP"	"R01570C"	"HMR_4485"	"r0352"	"R01570"	"MNXR104887"	""	"RCR11165"	"TMDPP"	"HMR_4485"	"RHEA:16040"	"RHEA:16037"	""	0
-"MAR06981"	""	""	"HMR_6981"	""	"R03283"	"MNXR108074"	""	"RCR11344"	"TMABADH"	"HMR_6981"	""	"RHEA:17985"	""	0
+"MAR06981"	"R_TMABADH;TMABADH"	""	"HMR_6981"	""	"R03283"	"MNXR108074;MNXR104876"	""	"RCR11344"	"TMABADH"	"HMR_6981"	""	"RHEA:17985"	""	0
 "MAR02365"	""	""	"HMR_2365"	""	""	""	""	"RCR11905"	"HMR_2365"	"HMR_2365"	""	""	""	0
 "MAR02505"	""	"RE3135C"	"HMR_2505"	""	""	""	""	"RCR10166"	"DESAT24_1"	"HMR_2505"	""	""	""	0
-"MAR02380"	"HMR_2380"	""	"HMR_2380"	"r1470"	""	""	""	"RCR12026"	"HMR_2380"	"HMR_2380"	""	""	""	0
 "MAR06634"	""	""	"HMR_6634"	""	""	""	""	"RCR13883"	"HMR_6634"	"HMR_6634"	""	""	""	0
 "MAR06641"	""	"RE1938C"	"HMR_6641"	""	""	"MNXR103582"	""	"RCR13887"	"RE1938C"	"HMR_6641"	""	""	""	0
 "MAR06642"	""	"RE1938R"	"HMR_6642"	""	""	"MNXR103582"	""	"RCR13888"	"RE1938R"	"HMR_6642"	""	""	""	0
@@ -11893,7 +11881,8 @@ rxns	rxnBiGGID	rxnEHMNID	rxnHMR2ID	rxnHepatoNET1ID	rxnKEGGID	rxnMetaNetXID	rxnRE
 "MAR08616"	"CBLATm"	""	"HMR_8616"	""	"R01492"	"MNXR96476"	""	"RCR20531"	"CBLATm"	"HMR_8616"	""	"RHEA:28671"	""	0
 "MAR06464"	""	"RE2382C"	"HMR_6464"	""	""	"MNXR103661"	""	"RCR14002"	"RE2382C"	"HMR_6464"	"RHEA:45113"	"RHEA:45112"	""	0
 "MAR06466"	""	"RE2398C"	"HMR_6466"	""	""	"MNXR103666"	""	"RCR14004"	"RE2398C"	"HMR_6466"	""	""	""	0
-"MAR06477"	""	"RE2387R"	"HMR_6477"	""	""	"MNXR103665"	""	"RCR14011"	"RE2387R"	"HMR_6477"	""	""	""	0
-"MAR06479"	""	"RE2383R"	"HMR_6479"	""	""	"MNXR103662"	""	"RCR14013"	"RE2383R"	"HMR_6479"	""	""	""	0
+"MAR06476"	""	"RE2387C"	"HMR_6476"	""	""	"MNXR103665"	""	"RCR14010"	"RE2387C"	"HMR_6476"	""	""	""	0
+"MAR06478"	""	"RE2383C"	"HMR_6478"	""	""	"MNXR103662"	""	"RCR14012"	"RE2383C"	"HMR_6478"	""	""	""	0
 "MAR08614"	"CBLATm"	""	"HMR_8614"	""	""	"MNXR96476"	""	"RCR20663"	"CBL2tm"	"HMR_8614"	""	""	""	0
-"MAR00149"	"DESAT18_6"	""	""	""	""	"MNXR97246"	""	""	"DESAT18_6"	"DESAT18_6"	""	""	""	0
+"MAR00145"	"DESAT18_10"	""	""	""	""	"MNXR97241"	""	""	"DESAT18_10"	"DESAT18_10"	""	""	""	0
+"MAR00151"	"DESAT18_8"	""	""	""	""	"MNXR97248"	""	""	"DESAT18_8"	"DESAT18_8"	""	""	""	0
diff --git a/version.txt b/version.txt
index 88c5fb8..bc80560 100644
--- a/version.txt
+++ b/version.txt
@@ -1 +1 @@
-1.4.0
+1.5.0