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CHANGELOG.md

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## v2.2.0 - 2023-04-14
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### Added
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- Added progress bar to bam processing step
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### Fixed
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- Clarified error message when an unmapped alignment file is input
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## v2.1.1 - 2023-04-04
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### Fixed
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- Fix parse error in MM/ML methylation tags
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- An infrequent error occurred when a reverse-mapped read ends (in sequenced orientation) with a methylated C base
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- An infrequent error occurred when a reverse-mapped read ends (in sequenced orientation) with a C base annotated by the MM tag
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- Fixes #41
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## v2.1.0 - 2023-03-27

README.md

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To use `aligned_bam_to_cpg_scores` download the latest release tarball compiled for 64-bit linux platforms on the
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[github release channel](https://github.com/PacificBiosciences/pb-CpG-tools/releases/latest), then unpack the tar file.
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As an example, the v2.1.1 release can be obtained as follows:
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As an example, the v2.2.0 release can be obtained as follows:
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wget https://github.com/PacificBiosciences/pb-CpG-tools/releases/download/v2.1.1/pb-CpG-tools-v2.1.1-x86_64-unknown-linux-gnu.tar.gz
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tar -xzf pb-CpG-tools-v2.1.1-x86_64-unknown-linux-gnu.tar.gz
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wget https://github.com/PacificBiosciences/pb-CpG-tools/releases/download/v2.2.0/pb-CpG-tools-v2.2.0-x86_64-unknown-linux-gnu.tar.gz
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tar -xzf pb-CpG-tools-v2.2.0-x86_64-unknown-linux-gnu.tar.gz
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# Run help option to test binary and see latest usage details:
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pb-CpG-tools-v2.1.1-x86_64-unknown-linux-gnu/bin/aligned_bam_to_cpg_scores --help
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pb-CpG-tools-v2.2.0-x86_64-unknown-linux-gnu/bin/aligned_bam_to_cpg_scores --help
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`aligned_bam_to_cpg_scores` includes a number of ways to summarize site propabilities for 5mC methylation,
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detailed below. The recommended default workflow will use the `model` pileup mode and `denovo` modsites mode.
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Continuing from the example above, the script below runs the tool on a mapped WGS bam for HG002:
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pb-CpG-tools-v2.1.1-x86_64-unknown-linux-gnu/bin/aligned_bam_to_cpg_scores \
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pb-CpG-tools-v2.2.0-x86_64-unknown-linux-gnu/bin/aligned_bam_to_cpg_scores \
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--bam HG002.hg38.pbmm2.bam \
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--output-prefix HG002.hg38.pbmm2 \
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--model pb-CpG-tools-v2.1.1-x86_64-unknown-linux-gnu/models/pileup_calling_model.v1.tflite \
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--model pb-CpG-tools-v2.2.0-x86_64-unknown-linux-gnu/models/pileup_calling_model.v1.tflite \
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--threads 8
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See the cmdline usage help for the full list of other commandline options:

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