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in overlap position, gencore doesn't reset quality #48

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wyy1234-github opened this issue Mar 24, 2023 · 0 comments
Open

in overlap position, gencore doesn't reset quality #48

wyy1234-github opened this issue Mar 24, 2023 · 0 comments

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@wyy1234-github
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wyy1234-github commented Mar 24, 2023

hi ,
in the document : In the overlapped region, if a base and its pair are mismatched, its quality score will be adjusted to: max(0, this_qual - pair_qual), but i find the quality score doesn't reset,
image
the 134G8 means G>T in the first read, and the second read is still G, the quality of this position are both D(Q35), so G>T mutation is called by vardict since the quality seems good.

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