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<!DOCTYPE html>
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<h5><a style="background-color: black">Who We Are</a></h5>
<p><a style="background-color: black">We are a group of researchers at the Genome Insitute of Singapore interested in developing and applying a new kind of 'in situ omics' technology for spatially resolved systems biology.</a></p>
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<h5><a style="background-color: black">What We Do</a></h5>
<p><a style="background-color: black">Physiological processes take place under intricate cellular coordination. We use state of the art imaging and Next-gen Sequencing, combined with cutting edge computational tools to analyze genomics, transcriptomics, and other information of single cells from tissues.</a></p>
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<h5><a style="background-color: black">How We Do</a></h5>
<p><a style="background-color: black">MERFISH: to profile transcripts at high throughput, different species of RNAs are labeled via FISH probes in a combinatorial fashion. Barcodes are then reconstructed via sequential rounds of hybridization and imaging.</a></p>
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<h5><a style="background-color: black">Why We Do</a></h5>
<p><a style="background-color: black">Such omics data can reveal molecularly defined cell types, gene networks, as well as cellular signaling events within their spatial context, all of which are critical for understanding tissue biology and disease mechanisms.</a></p>
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<img src="images/kh-24.jpg" alt="Kok Hao CHEN, PhD" class="rounded-circle" style="width: 140px; height: 140px">
<h4><a href="https://orcid.org/0000-0001-7406-7919">Kok Hao CHEN, Ph.D.</a></h4>
<p>Principal Scientist II</p>
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<img src="images/nigel.jpg" alt="Shijie, Nigel CHOU, Ph.D" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Shijie, Nigel CHOU, Ph.D.</h4>
<p>Senior Scientist I</p>
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<h4>Wan Yi SEOW</h4>
<p>Senior Research Officer I</p>
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<img src="images/xinrui.png" alt="Xinrui ZHOU, Ph.D" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Xinrui ZHOU, Ph.D.</h4>
<p>Senior Scientist I</p>
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<img src="images/yenling.jpg" alt="Yen Ling LEE" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Yen Ling LEE</h4>
<p>Lead Research Officer II</p>
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<img src="images/tu.png" alt="Dao Tuc Tu, Ph.D" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Dao Tuc Tu, Ph.D.</h4>
<p>Scientist</p>
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<img src="images/caojiao.jpg" alt="Jiao, CAO, Ph.D" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Jiao, CAO, Ph.D.</h4>
<p>Scientist</p>
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<img src="images/jose.jpg" alt="Gallery" class="rounded-circle" style="width: 140px; height: 140px">
<h4>Jose Guijarro Nuez</h4>
<p>A*STAR ARAP-MRC DTP Scholar (PhD student)</p>
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<h1 class="text-black text-center">Former Members</h1>
<hr class="w-25 mx-auto" />
<div class="former-pad">
<p>● Maurice Lee, 2020-2025. </p>
<p>● Vipul Singhal, 2018-2024. Head of Computational Biology at Integrated Biosciences</p>
<p>● Nigel Chou Shijie, 2017-2023. GIS Fellow at Genome Institute of Singapore</p>
<p>● Lurong Wang, 2022-2024. Research Officer at Genome Institute of Singapore</p>
<p>● Jiamin Toh, 2019-2024. Research Officer at Genome Institute of Singapore</p>
<p>● Norbert Ha, 2019-2024. Biomedical Scientist at Delta Electronics</p>
<p>● Jack Petts-Lewis, 2021-2023. Graduate Student at University of Warwick</p>
<p>● Lingfan Jiang, 2019-2023. Research Scientist at KLA</p>
<p>● Jazlynn Tan, 2022. University of Toronto</p>
<p>● Jeeranan Boonruangkan, 2018-2022. Biofourmis</p>
<p>● Jie Lin Jolene Goh, 2016-2022. Veranome Biosystems</p>
<p>● Mike Jin-An Huang, 2018-2021. 1910 Genetics</p>
<p>● Paul Cheng, 2018-2021. Veranome Biosystems</p>
<p>● Kaviya Selva Raju, 2018-2020. Research Associate at Applied Materials</p>
<p>● Siyi Chen, 2018. Senior Scientist at Maiden Therapeutics</p>
<p>● Christabelle Goh, 2018. Scientist II at Applied Materials</p>
<p>● Ziqing, Winston Zhao, 2018-2019. Assistant Professor at National University of Singapore</p>
<p>● Teck Por Lim, 2018-2019.</p>
<p>● Mei Lun Chow, 2018. Project Officer at Nanyang Technological University</p>
</div>
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<section class="main_heading my-5 mt-5" id="Publications">
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<h1 class="display-4">Publications</h1>
<hr class="w-25 mx-auto" />
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<div class="gallery-container">
<div class="row">
<div class="col mx-auto ">
<figure>
<a href="https://www.nature.com/articles/s41467-024-46669-y"><img src="images/FISHnCHIPs.png" alt="FISHnCHIPs" class="rectangle" style="width: 142px; height: 190px"></a>
</figure>
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<figure>
<a href="https://www.nature.com/articles/s41588-024-01664-3"><img src="images/BANKSY.png" alt="BANKSY" class="rectangle" style="width: 142px; height: 190px"></a>
</figure>
</div>
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<figure>
<a href="https://www.nature.com/articles/s41592-020-0858-0"><img src="images/splitfish.png" alt="Split-FISH" class="rectangle" style="width: 142px; height: 190px"></a>
</figure>
</div>
<div class="col mx-auto ">
<figure>
<a href="https://science.sciencemag.org/content/348/6233/aaa6090.full"><img src="images/merfish.png" alt="MERFISH" class="rectangle" style="width: 142px; height: 190px"></a>
</figure>
</div>
</div>
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<h1 class="text-black text-center">Publication list</h1>
<hr class="w-25 mx-auto" />
<div class="pub-pad">
<p><a href="https://www.nature.com/articles/s41467-024-46669-y" target="_blank">Zhou, X.*, Seow, W. Y.*, Ha, N., Cheng, T. H., Jiang, L. F., Boonruangkan, J., Goh, J. J. L., Prabhakar, S., Chou, N.#, Chen, K. H.#, Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes, Nature Communications, (2024) DOI: 10.1038/s41467-024-46669-y.</a></p>
<p><a href="https://www.nature.com/articles/s41588-024-01664-3" target="_blank">Singhal, V.*, Chou, N.*, Lee, J., Yue, Y., Liu, J., Chock, W. K., Lin, Li, Chang, Y., Teo, E., Lee, H. K., Chen, K. H.#, Prabhakar, S.#, BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis, Nature Genetics, (2024) DOI: 10.1038/s41588-024-01664-3.</a></p>
<p><a href="https://www.nature.com/articles/s41592-020-0858-0" target="_blank">Goh, J. J. L.*, Chou, N.*, Seow, W. Y., Ha, N., Cheng, C. P. P., Chang, Y., Zhao, Z. W., Chen, K. H. Highly specific multiplexed RNA imaging in tissues with split-FISH. Nature Methods, (2020) https://doi.org/10.1038/s41592-020-0858-0.</a></p>
<p><a href="https://www.nature.com/articles/ng.3818" target="_blank">Li, H., Courtois, E. T., Sengupta, D., Tan, Y., Chen, K. H., Goh, J. J. L., et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nature Genetics (49), 708–718 (2017).</a></p>
<p><a href="https://www.pnas.org/doi/10.1073/pnas.1612826113" target="_blank">Moffitt, J. R.*, Hao, J.*, Wang, G.*, Chen, K. H., Babcock, H. P. & Zhuang, X. High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization. P.N.A.S. 113 (39), 11046-11051 (2016).</a></p>
<p><a href="https://www.science.org/doi/10.1126/science.aaa6090" target="_blank">Chen, K. H.*, Boettiger, A. N.*, Moffitt, J. R.*, Wang, S. & Zhuang, X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 348, aaa6090 (2015).</a></p>
<p><a href="https://pubs.acs.org/doi/10.1021/nn302779m" target="_blank">Cha, T. G., Baker, B.A., Salgado J., Bates C.J., Chen K.H., Chang A.C., Han J.C., Strano M.S., & Choi J.H. Understanding oligonucleotide-templated nanocrystals: Growth mechanisms and surface properties. ACS Nano 6, 8136–8143 (2012).</a></p>
<p><a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cphc.201100735" target="_blank">Bates, M., Dempsey, G. T., Chen, K. H. & Zhuang, X. Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection. ChemPhysChem 13, 99–107 (2012).</a></p>
<p><a href="https://pubs.rsc.org/en/content/articlelanding/2011/lc/c0lc00644k" target="_blank">Chen, K. H., Hobley, J., Foo, Y. L. & Su, X. Wide-field single metal nanoparticle spectroscopy for high throughput localized surface plasmon resonance sensing. Lab Chip 11, 1895–1901 (2011).</a></p>
<p><a href="https://www.nature.com/articles/nmeth.1768" target="_blank">Dempsey, G. T.*, Vaughan, J. C.*, Chen, K. H.*, Bates, M. & Zhuang, X. Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nature Methods 8, 1027–1036 (2011).</a></p>
<p><a href="https://pubs.acs.org/doi/10.1021/ac101714u" target="_blank">Ishitsuka, Y., Okumus, B., Arslan, S., Chen,q K. H. & Ha, T. Temperature-independent porous nanocontainers for single-molecule fluorescence studies. Anal. Chem. 82, 9694–9701 (2010).</a></p>
<p><a href="https://pubs.acs.org/doi/10.1021/jp0765648" target="_blank">Mateo-Alonso, A., Ehli, C., Chen, K. H., Guldi, D. M. & Prato, M. Dispersion of single-walled carbon nanotubes with an extended diazapentacene derivative. J. Phys. Chem. A 111, 12669–12673 (2007).</a></p>
<p><a href="https://pubs.acs.org/doi/10.1021/ja066506k" target="_blank">Choi, J. H., Chen, K. H. & Strano, M. S. Aptamer-capped nanocrystal quantum dots: A new method for label-free protein detection. J. Am. Chem. Soc. 128, 15584–15585 (2006).</a></p>
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<p>We’re located on level 5 of the Genome Institute of Singapore, at the Biopolis research campus in the One-North area.</p>
<p>Our mailing address is: Genome Institute of Singapore (GIS), 60 Biopolis Street Level 5, Genome Building, Singapore 138672</p>
<p>Positions available.
Email:chenkh(at) gis.a-star.edu.sg</p>
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