Residue-mapping error because of sequence change in UniProt

[HrishiDhondge]

The sequence of PTBP1_HUMAN (P26599) has changed in UniProt. It has 4 RRM domains, 2 each from RRM_1 (PF00076) and RRM_5 (PF13893).

• RRM_5:
  • (38, 152),
  • (309, 433) --> This Structural InstancStI is causing the error
• RRM_1:
  • (186, 252),
  • (456, 521)

The above sequence numbering matches with UniProt sequence versions=238, but the sequence changed in versions=239.
With the change in UniProt version, the corresponding SIFTS file has also changed accordingly, but not Pfam (v35.0).
This sequence change is causing workflow errors during the residue-mapping step of P26599_A (309, 433), recognizing only the domain end residue.
According to the new sequence, the RRM domain starts at 335, and the corresponding PDB (2EVZ) starts from the 350th amino acid residue of the UniProt sequence.

The issue can be replicated with the current version of the workflow (v1.0.0) by using the CWL tool Tools/resmapping_pfam_instances_subwf.cwl (sub-workflow for residue-mapping of Pfam StIs).
Query this tool for RRM_5 (PF13893) Pfam family.