diff --git a/benchmark/sirun/appsec-iast/insecure-bank.js b/benchmark/sirun/appsec-iast/insecure-bank.js
index d07ab7c762f..883ed471e77 100644
--- a/benchmark/sirun/appsec-iast/insecure-bank.js
+++ b/benchmark/sirun/appsec-iast/insecure-bank.js
@@ -1,5 +1,5 @@
 const http = require('http')
-const app = require('/opt/insecure-bank-js/app') // eslint-disable-line import/no-absolute-path
+const app = require('/opt/insecure-bank-js/app') // eslint-disable-line import/no-absolute-path, n/no-missing-require
 
 const { port } = require('./common')
 
diff --git a/benchmark/sirun/appsec/insecure-bank.js b/benchmark/sirun/appsec/insecure-bank.js
index d07ab7c762f..883ed471e77 100644
--- a/benchmark/sirun/appsec/insecure-bank.js
+++ b/benchmark/sirun/appsec/insecure-bank.js
@@ -1,5 +1,5 @@
 const http = require('http')
-const app = require('/opt/insecure-bank-js/app') // eslint-disable-line import/no-absolute-path
+const app = require('/opt/insecure-bank-js/app') // eslint-disable-line import/no-absolute-path, n/no-missing-require
 
 const { port } = require('./common')
 
diff --git a/benchmark/sirun/plugin-bluebird/index.js b/benchmark/sirun/plugin-bluebird/index.js
index 2e168ac71fe..0fb94145e18 100644
--- a/benchmark/sirun/plugin-bluebird/index.js
+++ b/benchmark/sirun/plugin-bluebird/index.js
@@ -4,6 +4,7 @@ if (Number(process.env.USE_TRACER)) {
   require('../../..').init()
 }
 
+// eslint-disable-next-line n/no-missing-require
 const Promise = require('../../../versions/bluebird/node_modules/bluebird/js/release/bluebird')
 
 const count = process.env.COUNT ? Number(process.env.COUNT) : 50000
diff --git a/esbuild.js b/esbuild.js
index 424ba5cb908..5c80493515a 100644
--- a/esbuild.js
+++ b/esbuild.js
@@ -1,3 +1,5 @@
 'use strict'
 
+// TODO: It shouldn't be necessary to disable n/no-unpublished-require - Research
+// eslint-disable-next-line n/no-unpublished-require
 module.exports = require('./packages/datadog-esbuild/index.js')
diff --git a/eslint.config.mjs b/eslint.config.mjs
index d15cf190fff..0d93f4cedef 100644
--- a/eslint.config.mjs
+++ b/eslint.config.mjs
@@ -40,11 +40,21 @@ export default [
   },
   { name: '@eslint/js/recommnded', ...js.configs.recommended },
   ...compat.extends('standard').map((config, i) => ({ name: config.name || `standard/${i + 1}`, ...config })),
+  {
+    ...n.configs['flat/recommended'],
+    ignores: [
+      'packages/dd-trace/test/appsec/next/app-dir/**/*.js',
+      'packages/dd-trace/test/appsec/next/pages-dir/**/*.js',
+      'packages/datadog-plugin-next/test/app/**/*.js',
+      'packages/datadog-plugin-next/test/**/pages/**/*.js',
+      'packages/datadog-plugin-next/test/middleware.js',
+      '**/*.mjs' // TODO: This shoudln't be required, research why it is
+    ]
+  },
   {
     name: 'dd-trace/defaults',
 
     plugins: {
-      n,
       '@stylistic/js': stylistic
     },
 
@@ -72,6 +82,15 @@ export default [
       '@stylistic/js/object-curly-spacing': ['error', 'always'],
       'import/no-extraneous-dependencies': 'error',
       'n/no-restricted-require': ['error', ['diagnostics_channel']],
+      'n/hashbang': 'off', // TODO: Enable this rule once we have a plan to address it
+      'n/no-process-exit': 'off', // TODO: Enable this rule once we have a plan to address it
+      'n/no-unsupported-features/node-builtins': ['error', {
+        ignores: [
+          'async_hooks.createHook',
+          'async_hooks.executionAsyncId',
+          'async_hooks.executionAsyncResource'
+        ]
+      }],
       'no-console': 'error',
       'no-prototype-builtins': 'off', // Override (turned on by @eslint/js/recommnded)
       'no-unused-expressions': 'off', // Override (turned on by standard)
@@ -107,7 +126,8 @@ export default [
       'mocha/no-sibling-hooks': 'off',
       'mocha/no-skipped-tests': 'off',
       'mocha/no-top-level-hooks': 'off',
-      'n/handle-callback-err': 'off'
+      'n/handle-callback-err': 'off',
+      'n/no-missing-require': 'off'
     }
   },
   {
diff --git a/index.js b/index.js
index a8c61274ad8..ed48ff2fea5 100644
--- a/index.js
+++ b/index.js
@@ -1,3 +1,5 @@
 'use strict'
 
+// TODO: It shouldn't be necessary to disable n/no-unpublished-require - Research
+// eslint-disable-next-line n/no-unpublished-require
 module.exports = require('./packages/dd-trace')
diff --git a/init.js b/init.js
index 625d493b3b1..63fa9ba96be 100644
--- a/init.js
+++ b/init.js
@@ -2,6 +2,8 @@
 
 /* eslint-disable no-var */
 
+// TODO: It shouldn't be necessary to disable n/no-unpublished-require - Research
+// eslint-disable-next-line n/no-unpublished-require
 var guard = require('./packages/dd-trace/src/guardrails')
 
 module.exports = guard(function () {
diff --git a/initialize.mjs b/initialize.mjs
index b7303848430..d9b08512797 100644
--- a/initialize.mjs
+++ b/initialize.mjs
@@ -10,6 +10,8 @@
   * hook will always be active for ESM support.
   */
 
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['module.register'] }] */
+
 import { isMainThread } from 'worker_threads'
 
 import * as Module from 'node:module'
diff --git a/integration-tests/appsec/esm-app/index.mjs b/integration-tests/appsec/esm-app/index.mjs
index 44dce0b46dc..dd531248f76 100644
--- a/integration-tests/appsec/esm-app/index.mjs
+++ b/integration-tests/appsec/esm-app/index.mjs
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['module.register'] }] */
 
 import childProcess from 'node:child_process'
 import express from 'express'
diff --git a/integration-tests/appsec/multer.spec.js b/integration-tests/appsec/multer.spec.js
index b87d7d268b0..cd95ce211e4 100644
--- a/integration-tests/appsec/multer.spec.js
+++ b/integration-tests/appsec/multer.spec.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { allowExperimental: true }] */
 
 const { assert } = require('chai')
 const path = require('path')
diff --git a/integration-tests/ci-visibility/run-workerpool.js b/integration-tests/ci-visibility/run-workerpool.js
index 4ab60a1fc0c..6dbd24e6951 100644
--- a/integration-tests/ci-visibility/run-workerpool.js
+++ b/integration-tests/ci-visibility/run-workerpool.js
@@ -1,4 +1,4 @@
-const workerpool = require('workerpool')
+const workerpool = require('workerpool') // eslint-disable-line n/no-extraneous-require
 const pool = workerpool.pool({ workerType: 'process' })
 
 function add (a, b) {
diff --git a/integration-tests/ci-visibility/subproject/cypress.config.js b/integration-tests/ci-visibility/subproject/cypress.config.js
index 9a786e4ef75..598e98ced81 100644
--- a/integration-tests/ci-visibility/subproject/cypress.config.js
+++ b/integration-tests/ci-visibility/subproject/cypress.config.js
@@ -2,7 +2,7 @@ module.exports = {
   defaultCommandTimeout: 100,
   e2e: {
     setupNodeEvents (on, config) {
-      return require('dd-trace/ci/cypress/plugin')(on, config)
+      return require('dd-trace/ci/cypress/plugin')(on, config) // eslint-disable-line n/no-extraneous-require
     },
     specPattern: process.env.SPEC_PATTERN || 'cypress/e2e/**/*.cy.js'
   },
diff --git a/integration-tests/ci-visibility/subproject/cypress/plugins-old/index.js b/integration-tests/ci-visibility/subproject/cypress/plugins-old/index.js
index f80695694a9..097d842adcb 100644
--- a/integration-tests/ci-visibility/subproject/cypress/plugins-old/index.js
+++ b/integration-tests/ci-visibility/subproject/cypress/plugins-old/index.js
@@ -1 +1 @@
-module.exports = require('dd-trace/ci/cypress/plugin')
+module.exports = require('dd-trace/ci/cypress/plugin') // eslint-disable-line n/no-extraneous-require
diff --git a/integration-tests/ci-visibility/subproject/cypress/support/e2e.js b/integration-tests/ci-visibility/subproject/cypress/support/e2e.js
index 26fdad7588a..e758459d14b 100644
--- a/integration-tests/ci-visibility/subproject/cypress/support/e2e.js
+++ b/integration-tests/ci-visibility/subproject/cypress/support/e2e.js
@@ -1 +1 @@
-require('dd-trace/ci/cypress/support')
+require('dd-trace/ci/cypress/support') // eslint-disable-line n/no-extraneous-require
diff --git a/integration-tests/ci-visibility/subproject/subproject-test.js b/integration-tests/ci-visibility/subproject/subproject-test.js
index 1545789c108..262f93e2dd4 100644
--- a/integration-tests/ci-visibility/subproject/subproject-test.js
+++ b/integration-tests/ci-visibility/subproject/subproject-test.js
@@ -1,4 +1,3 @@
-const { expect } = require('chai')
 const dependency = require('./dependency')
 
 describe('subproject-test', () => {
diff --git a/packages/datadog-instrumentations/src/fetch.js b/packages/datadog-instrumentations/src/fetch.js
index 94f40b6a70d..d418ec5949b 100644
--- a/packages/datadog-instrumentations/src/fetch.js
+++ b/packages/datadog-instrumentations/src/fetch.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['fetch', 'Request'] }] */
 
 const shimmer = require('../../datadog-shimmer')
 const { tracingChannel } = require('dc-polyfill')
diff --git a/packages/datadog-instrumentations/test/multer.spec.js b/packages/datadog-instrumentations/test/multer.spec.js
index 8bd01b5af49..b699f1c4e82 100644
--- a/packages/datadog-instrumentations/test/multer.spec.js
+++ b/packages/datadog-instrumentations/test/multer.spec.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['FormData'] }] */
 
 const dc = require('dc-polyfill')
 const axios = require('axios')
diff --git a/packages/datadog-plugin-fetch/test/index.spec.js b/packages/datadog-plugin-fetch/test/index.spec.js
index bf18053952f..130c9c44637 100644
--- a/packages/datadog-plugin-fetch/test/index.spec.js
+++ b/packages/datadog-plugin-fetch/test/index.spec.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['fetch', 'Request'] }] */
 
 const agent = require('../../dd-trace/test/plugins/agent')
 const tags = require('../../../ext/tags')
diff --git a/packages/datadog-plugin-fetch/test/integration-test/client.spec.js b/packages/datadog-plugin-fetch/test/integration-test/client.spec.js
index 922c889134d..a491883e40e 100644
--- a/packages/datadog-plugin-fetch/test/integration-test/client.spec.js
+++ b/packages/datadog-plugin-fetch/test/integration-test/client.spec.js
@@ -7,6 +7,7 @@ const {
 } = require('../../../../integration-tests/helpers')
 const { assert } = require('chai')
 
+// eslint-disable-next-line n/no-unsupported-features/node-builtins
 const describe = globalThis.fetch ? globalThis.describe : globalThis.describe.skip
 
 describe('esm', () => {
diff --git a/packages/datadog-plugin-fetch/test/integration-test/server.mjs b/packages/datadog-plugin-fetch/test/integration-test/server.mjs
index 578d66a12ca..9835bd5bcd3 100644
--- a/packages/datadog-plugin-fetch/test/integration-test/server.mjs
+++ b/packages/datadog-plugin-fetch/test/integration-test/server.mjs
@@ -1,3 +1,5 @@
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['fetch'] }] */
+
 import 'dd-trace/init.js'
 import getPort from 'get-port'
 
diff --git a/packages/dd-trace/src/appsec/iast/taint-tracking/rewriter.js b/packages/dd-trace/src/appsec/iast/taint-tracking/rewriter.js
index 9b446f2416e..6b22bd0e083 100644
--- a/packages/dd-trace/src/appsec/iast/taint-tracking/rewriter.js
+++ b/packages/dd-trace/src/appsec/iast/taint-tracking/rewriter.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['module.register'] }] */
 
 const Module = require('module')
 const { pathToFileURL } = require('url')
diff --git a/packages/dd-trace/src/debugger/devtools_client/inspector_promises_polyfill.js b/packages/dd-trace/src/debugger/devtools_client/inspector_promises_polyfill.js
index bb4b0340be6..a940065a62d 100644
--- a/packages/dd-trace/src/debugger/devtools_client/inspector_promises_polyfill.js
+++ b/packages/dd-trace/src/debugger/devtools_client/inspector_promises_polyfill.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['inspector/promises'] }] */
 
 const { builtinModules } = require('node:module')
 
diff --git a/packages/dd-trace/src/profiling/exporters/event_serializer.js b/packages/dd-trace/src/profiling/exporters/event_serializer.js
index 9cfc89eb5f2..df83c6b96a5 100644
--- a/packages/dd-trace/src/profiling/exporters/event_serializer.js
+++ b/packages/dd-trace/src/profiling/exporters/event_serializer.js
@@ -1,3 +1,6 @@
+'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['os.availableParallelism'] }] */
+
 const os = require('os')
 const perf = require('perf_hooks').performance
 const version = require('../../../../../package.json').version
diff --git a/packages/dd-trace/src/runtime_metrics.js b/packages/dd-trace/src/runtime_metrics.js
index f16b227ca18..55574b093ed 100644
--- a/packages/dd-trace/src/runtime_metrics.js
+++ b/packages/dd-trace/src/runtime_metrics.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['v8.GCProfiler'] }] */
 
 // TODO: capture every second and flush every 10 seconds
 
diff --git a/packages/dd-trace/test/appsec/iast/analyzers/path-traversal-analyzer.spec.js b/packages/dd-trace/test/appsec/iast/analyzers/path-traversal-analyzer.spec.js
index f914006b5e0..e796379addb 100644
--- a/packages/dd-trace/test/appsec/iast/analyzers/path-traversal-analyzer.spec.js
+++ b/packages/dd-trace/test/appsec/iast/analyzers/path-traversal-analyzer.spec.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['fs.cp'] }] */
 
 const os = require('os')
 const path = require('path')
diff --git a/packages/dd-trace/test/appsec/iast/resources/vm.js b/packages/dd-trace/test/appsec/iast/resources/vm.js
index 3719d445c43..63f648aae50 100644
--- a/packages/dd-trace/test/appsec/iast/resources/vm.js
+++ b/packages/dd-trace/test/appsec/iast/resources/vm.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['vm.SourceTextModule'] }] */
 
 const tracer = require('dd-trace')
 tracer.init({
diff --git a/packages/dd-trace/test/appsec/index.next.plugin.spec.js b/packages/dd-trace/test/appsec/index.next.plugin.spec.js
index de711c5ff94..8acb5e780a9 100644
--- a/packages/dd-trace/test/appsec/index.next.plugin.spec.js
+++ b/packages/dd-trace/test/appsec/index.next.plugin.spec.js
@@ -1,4 +1,5 @@
 'use strict'
+/* eslint n/no-unsupported-features/node-builtins: ['error', { ignores: ['fs.cpSync'] }] */
 
 const { spawn, execSync } = require('child_process')
 const { cpSync, mkdirSync, rmdirSync, unlinkSync } = require('fs')
diff --git a/register.js b/register.js
index 58adc77bd68..5144929337d 100644
--- a/register.js
+++ b/register.js
@@ -1,3 +1,5 @@
+/* eslint n/no-unsupported-features/node-builtins: ['error', { version: '>=20.6.0', allowExperimental: true }] */
+
 const { register } = require('node:module')
 const { pathToFileURL } = require('node:url')
 
diff --git a/scripts/get-chrome-driver-download-url.js b/scripts/get-chrome-driver-download-url.js
index 99f98a9079b..10000ffaf9e 100644
--- a/scripts/get-chrome-driver-download-url.js
+++ b/scripts/get-chrome-driver-download-url.js
@@ -1,3 +1,5 @@
+/* eslint n/no-unsupported-features/node-builtins: ['error', { version: '>=21.0.0', allowExperimental: true }] */
+
 const URL = 'https://googlechromelabs.github.io/chrome-for-testing/known-good-versions-with-downloads.json'
 
 // Get chrome driver download URL from a given chrome version, provided via CHROME_VERSION env var
diff --git a/scripts/verify-ci-config.js b/scripts/verify-ci-config.js
index becc7287487..94cbb9b6a70 100644
--- a/scripts/verify-ci-config.js
+++ b/scripts/verify-ci-config.js
@@ -1,5 +1,6 @@
 'use strict'
 /* eslint-disable no-console */
+/* eslint n/no-unsupported-features/node-builtins: ['error', { version: '>=22.0.0', allowExperimental: true }] */
 
 const fs = require('fs')
 const path = require('path')